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Table 3 Overview of Medication Related Problems (MRP) according to frequency and types

From: Medication-related problems among hospitalized pregnant women in a tertiary teaching hospital in Ethiopia: a prospective observational study

MRPs Category

Type of MRP

n (%) a

Example

Indication

Needs additional drug therapy

236 (73.1)

Patient is asthmatic, but is not getting the recommended drug i.e. salbutamol puff PRN

Unnecessary drug therapy

38 (11.8)

Patient is on ceftriaxone 1 g IV BID but there is no indication of infection in the diagnosis

Effectivenes

Dosage too low

38 (11.8)

Cephalexin 500 mg once PO daily given to patient to treat infection, PO BID daily is recommended

Ineffective drug product

12 (3.7)

HIV/AIDS (immunocompromised) and MRSA infected patient who was on wound care was on metronidazole and cephalexin treatment (less effective), instead patient was put on more effective drug, vancomycin 500 mg IV BID for 10 days

Safety

Dosage too high

12 (3.7)

Patient is on ceftriaxone 2 g IV bid to treat chorioamnionitis which is high dose, 1 g IV BID is enough

Adverse drug reaction

2 (0.6)

Patient received furosemide and gentamicin concurrently. One increases toxicity of the other by pharmacodynamic synergism; alternative drug chlorothiazide was used in place of furosemide

Compliance

Non-compliance

12 (3.7)

Anti-D immunoglobulin is available in the hospital, but the patient couldn’t afford and was not injected

Other categories

Need for an additional laboratory test

41 (12.7)

Patient haematocrit value is not registered to recommend or not iron supplementation or treatment

Incomplete drug order

3 (0.9)

Patient is prescribed with methyldopa 250 mg (mild pre-eclampsia), but duration was not indicated

Total MRPs

 

394 (100.0)

 
  1. Abbreviations: BID Bis in die (twice daily); IV Intravenous; mg, milligram; MRP medication-related problem; MRSA Methicillin-resistant Staphylococcus aureus; SCAP Severe Community-Acquired Pneumonia; PRN, as needed; PO Per os (by mouth or orally)
  2. a Percentage is calculated taking those with ≥ MRP as denominator, N = 323. Percentage may exceed 100% due to more than one MRP per patient