Distribution of maternal red cell antibodies and the risk of severe alloimmune haemolytic disease of the foetus in a Chinese population: a cohort study on prenatal management

Table 5 The predictors of severe HDF in foetuses with anti-D and/or combined other antibodies

	Severe HDF (n = 91)	No severe HDF (n = 10)	P	Univariable OR (95% CI)	P	Multivariable OR^c (95% CI)
Female, n (%)	42 (46.2)	7 (70.0)	0.446	0.60 (0.157–2.257)	0.067	0.17 (0.026–1.138)
Maternal antibody titre^a	1:1024 (1:512-1:2048)	1:320 (1: 56 − 1:1024)	0.067	1.00 (1.000-1.003)	0.671	1.00 (0.999–1.002)
Gestational age at diagnosis, weeks^a	28.0 (23.3–32.1)	33.6 (32.7–34.0)	0.014	0.71 (0.544–0.934)	0.098	0.76 (0.543–1.053)
Reticulocyte count^b (10⁹/L)	318.4 ± 98.8	226.7 ± 59.4	0.012	1.01 (1.003–1.022)	0.041	1.01 (1.001–1.026)
Anti-D combined with others, n (%)	21 (23.1)	1 (10.0)	0.359	2.70 (0.323–22.556)	0.834	1.29 (0.119–14.052)

HDF haemolytic disease of the foetus; OR odds ratio
^aData present as the median (25th − 75th quartiles)
^bData presented as the mean ± SD
^cThe multivariable analysis included the following risk factors for analysis: foetal sex, maternal antibody titre, gestational age at diagnosis, reticulocyte count and anti-D combined with others

ISSN: 1471-2393