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Table 3 Pregnancy, delivery and neonatal outcomes of pregnant patients in the rescue ICSI and conventional ICSI groups

From: Perinatal and neonatal outcomes of pregnancies after early rescue intracytoplasmic sperm injection in women with primary infertility compared with conventional intracytoplasmic sperm injection: a retrospective 6-year study

 

Rescue ICSI group

Conventional ICSI group

 

Total

ICSI-1 subgroup

ICSI-2 subgroup

Pregnancy outcomes

 Clinical pregnancy, n (%)

68 (54.84)

232 (61.87)

52 (57.14)

180 (63.38)

 Single pregnancy, n (%)

33 (48.53)

127 (54.74)

26 (50.00)

101 (56.11)

 Twin pregnancy, n (%)

34 (50.00)

99 (42.67)

25 (48.08)

74 (41.11)

 Multiple pregnancy, n (%)

1 (1.47)

6 (2.59)

1 (1.92)

5 (2.78)

 Ectopic pregnancy per transfer, n (%)

2 (1.61)

3 (0.80)

1 (1.10)

2 (0.70)

 Multifetal pregnancy reduction, n (%)

2 (2.94)

9 (3.88)

4 (7.69)

5 (2.78)

 Implantation, n (%)

102/259 (39.38)

343/801 (42.82)

80/196 (40.82)

263/605 (43.47)

 Early miscarriage, n (%)

5 (7.35)

23 (9.91)

3 (5.77)

20 (11.11)

 Ongoing pregnancy per transfer, n (%)

63 (50.81)

209 (55.73)

49 (53.85)

160 (56.34)

 Live deliveries per transfer, n (%)a

62 (50.41)

200 (53.48)

47 (51.65)

153 (54.06)

Delivery outcomes

 Twins, n (%)

22 (35.48)

74 (37.00)

18 (38.30)

56 (36.60)

 Singleton, n (%)

40 (64.52)

126 (63.00)

29 (61.70)

97 (63.40)

 Gestational days

267.68 ± 15.39

266.86 ± 15.34

266.83 ± 16.87

266.86 ± 14.90

 Preterm birth (< 37 wk), n (%)

14 (22.95)

44 (22.56)

10 (22.73)

34 (25.52)

 Very preterm birth (< 32 wk), n (%)

1 (1.64)

4 (2.05)

2 (4.55)

2 (1.32)

 Cesarean section, n (%)

41 (66.13)

141 (70.50)

30 (63.83)

111 (72.55)

 Vaginal deliveries, n (%)

21 (33.87)

59 (29.50)

17 (36.17)

42 (27.45)

 GDM, n (%)

8 (12.90)

22 (11.00)

5 (10.64)

17 (11.11)

Neonatal outcomes

 Live birth

84

274

65

209

 Male neonates, n (%)

46 (54.76)

132 (48.18)

34 (52.31)

98 (46.89)

 Female neonates, n (%)

38 (45.23)

142 (51.82)

31 (47.69)

111 (53.11)

 Birth weight (g)

2792.62 ± 571.77

2742.82 ± 598.32

2688.95 ± 540.02

2759.57 ± 615.58

 Male birth weight (g)

2794.57 ± 585.03

2803.58 ± 611.79

2649.76 ± 535.81

2856.94 ± 629.80

 Female birth weight (g)

2790.26 ± 563.11

2686.34 ± 581.98

2731.94 ± 550.17

2673.60 ± 592.33

 LBW (<2500 g), n (%)

23 (27.38)

84 (30.66)

18 (27.69)

66 (31.58)

 VLBW (<1500 g), n (%)

1 (1.19)

5 (1.82)

1 (1.54)

4 (1.91)

 SGA, n (%)

3 (3.57)

26 (9.49)

7 (10.77)

19 (9.09)

 Admission to NICU, n (%)

11 (13.10)

38 (13.87)

11 (16.92)

27 (12.92)

 Days at the NICU

10.09 ± 6.59

15.55 ± 13.47

19.91 ± 11.03

13.78 ± 14.15

 Birth defects, n (%)

2 (2.38)

4 (1.46)

1 (1.54)

3 (1.44)

  1. Comparisons were made between the rescue ICSI group and the conventional ICSI group, and also within the two subgroups, but no significant difference was found
  2. ICSI intracytoplasmic sperm injection, GDM gestational diabetes mellitus, LBW low birth weight, VLBW very low birth weight, SAG small for gestation age, NICU neonatal intensive care unit
  3. aOne case of live birth outcome missing in rescue ICSI group and ICSI-2 subgroup, respectively