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Table 3 Diagnostic test performance for P. falciparum detection, compared to a reference standard (qRT-PCR)

From: Evaluation of highly sensitive diagnostic tools for the detection of P. falciparum in pregnant women attending antenatal care visits in Colombia

  qRT-PCR Total value (95% CI)
+ Sensitivity Specificity PPV NPV
Microscopy + 23 0 23 59.0% 100.0% 100.0% 98.1%
16 819 835 (42.1–74.4) (99.6–100.0) (85.2–100.0) (96.9–98.9)
cRDT + 21 0 21 53.8% 100.0% 100.0% 97.8%
18 819 837 (37.2–69.9) (99.6–100.0) (83.9–100.0) (96.6–98.7)
hsRDTa + 25 1 26 64.1% 99.9% 96.2% 98.3%
14 813 827 (47.2–78.8) (99.3–100.0) (80.4–99.9) (97.2–99.1)
LAMP + 35 1 36 89.7% 99.9% 97.2% 99.5%
4 818 822 (75.8–97.1) (99.3–100.0) (85.5–99.9) (98.8–99.9)
nPCR + 30 0 30 76.9% 100.0% 100.0% 98.9%
9 819 828 (60.7–88.9) (99.6–100.0) (88.4–100.0) (97.9–99.5)
  1. + positive, − negative, PPV positive predictive value, NPV negative predictive value, CI confidence interval. aFive samples with indeterminate result (not included). qRT-PCR Quantitative Reverse Transcription polymerase chain reaction, cRDT conventional rapid diagnostic test, hsRDT highly sensitive rapid diagnostic test, LAMP loop-mediated isothermal amplification, nPCR nested polymerase chain reaction