Table 3 Diagnostic test performance for P. falciparum detection, compared to a reference standard (qRT-PCR)
qRT-PCR | Total | value (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|
+ | – | Sensitivity | Specificity | PPV | NPV | |||
Microscopy | + | 23 | 0 | 23 | 59.0% | 100.0% | 100.0% | 98.1% |
– | 16 | 819 | 835 | (42.1–74.4) | (99.6–100.0) | (85.2–100.0) | (96.9–98.9) | |
cRDT | + | 21 | 0 | 21 | 53.8% | 100.0% | 100.0% | 97.8% |
– | 18 | 819 | 837 | (37.2–69.9) | (99.6–100.0) | (83.9–100.0) | (96.6–98.7) | |
hsRDTa | + | 25 | 1 | 26 | 64.1% | 99.9% | 96.2% | 98.3% |
– | 14 | 813 | 827 | (47.2–78.8) | (99.3–100.0) | (80.4–99.9) | (97.2–99.1) | |
LAMP | + | 35 | 1 | 36 | 89.7% | 99.9% | 97.2% | 99.5% |
– | 4 | 818 | 822 | (75.8–97.1) | (99.3–100.0) | (85.5–99.9) | (98.8–99.9) | |
nPCR | + | 30 | 0 | 30 | 76.9% | 100.0% | 100.0% | 98.9% |
– | 9 | 819 | 828 | (60.7–88.9) | (99.6–100.0) | (88.4–100.0) | (97.9–99.5) | |