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Table 4 Association between preeclampsia and maternal plasma TAMO concentration in the second trimester

From: Association between risk of preeclampsia and maternal plasma trimethylamine-N-oxide in second trimester and at the time of delivery

PE type

Quartile for TMAO concentration in the second trimester (μg/m3)

p for trend

Per 50 μg/m3 increment

Q1 (< 57.58)

Q2 (57.58- < 84.80)

Q3 (84.80- < 116.36)

Q4 (≥116.36)

PE

 Case / Control

21/ 45

9/ 57

14/ 52

22/ 44

  

 OR (95%CI)

Reference

0.34 (0.14, 0.81)

0.58 (0.26, 1.27)

1.07 (0.52, 2.22)

0.611

1.33 (0.98, 1.79)

 ORaadj (95%CI)

Reference

0.30 (0.12, 0.75)

0.57 (0.24, 1.32)

1.00 (0.47, 2.14)

0.867

1.23 (0.90, 1.68)

EOPE

 Case / Control

6/ 45

3/ 57

4/ 52

4/ 44

  

 OR (95%CI)

Reference

0.40 (0.09, 1.67)

0.58 (0.15, 2.17)

0.68 (0.18, 2.58)

0.643

0.89 (0.47, 1.67)

 ORaadj (95%CI)

Reference

0.34 (0.08, 1.53)

0.52 (0.13, 2.18)

0.66 (0.16, 2.65)

0.372

0.75 (0.39, 1.44)

LOPE

 Case / Control

15/ 45

6/ 57

10/ 52

18/ 44

  

 OR (95%CI)

Reference

0.32 (0.11, 0.88)

0.58 (0.24, 1.41)

1.23 (0.55, 2.74)

0.389

1.48 (1.06, 2.05)

 ORaadj (95%CI)

Reference

0.40 (0.16, 1.00)

0.61 (0.24, 1.56)

1.12 (0.48, 2.59)

0.521

1.41 (1.00, 1.98)

Mild PE

 Case / Control

14/ 45

4/ 57

7/ 52

16/ 44

  

 OR (95%CI)

Reference

0.23 (0.07, 0.73)

0.43 (0.16, 1.17)

1.17 (0.51, 2.68)

0.497

1.55 (1.09, 2.20)

 ORaadj (95%CI)

Reference

0.25 (0.05, 1.19)

0.43 (0.15, 1.30)

1.19 (0.50, 2.86)

0.510

1.35 (0.69, 2.64)

Severe PE

 Case / Control

7/ 45

5/ 57

7/ 52

6/ 44

  

 OR (95%CI)

Reference

0.56 (0.17, 1.90)

0.87 (0.28, 2.66)

0.88 (0.27, 2.82)

0.999

0.98 (0.58, 1.66)

 ORaadj (95%CI)

Reference

0.53 (0.15, 1.87)

0.89 (0.26, 2.97)

0.71 (0.20, 2.50)

0.550

0.83 (0.48, 1.43)

  1. a: Adjusted for year of education, pre-pregnancy BMI, smoking during pregnancy, fetal gender;
  2. Abbreviation: TMAO trimethylamine-N-oxide; PE preeclampsia; EOPE early onset preeclampsia; LOPE late onset preeclampsia; OR odds ratio; CI confidence interval