Association between vitamin D plasma concentrations and VDR gene variants and the risk of premature birth

Table 2 The genotype and allele frequencies of the TaqI, BsmI, ApaI, and FokI variants of the VDR gene in preterm and full-term mothers and newborns

VDR SNVs	Population	N	Genotypes					HWE	Alleles
VDR SNVs	Population	N	n (%)	n (%)	p	n (%)	p	HWE	n (%)	n (%)	p
Mothers
			AA	AG		GG			A	G
TaqI/A > G	Preterm	40	19 (47.5)	18 (45.0)	0.105	3 (7.5)	0.009	0.903	56 (70.0)	24 (30.0)	0.007
	Full-term	92	25 (27.2)	46 (50.0)		21 (22.8)		1.0	96 (52.2)	88 (47.8)
			CC	CT		TT			C	T
BsmI/C > T	Preterm	40	15 (37.5)	0	0.001	25 (62.5)	0.031	< 0.001	30 (37.5)	50 (62.5)	0.005
	Full-term	92	34 (37.0)	35 (38.0)		23 (25.0)		0.260	103 (56.0)	81 (44.0)
			CC	CA		AA			C	A
ApaI/C > A	Preterm	40	5 (12.5)	21 (52.5)	0.067	14 (35.0)	< 0.001	0.799	31 (38.8)	49 (61.2)	0.001
	Full-term	92	31 (33.7)	49 (53.3)		12 (13.0)		0.558	111 (60.3)	73 (39.7)
			AA	AG		GG			A	G
FokI/A > G	Preterm	40	4 (10.0)	18 (45.0)	0.284	18 (45.0)	0.323	0.987	26 (32.5)	54 (67.5)	0.436
	Full-term	92	16 (17.4)	37 (40.2)		39 (42.4)		0.397	69 (37.5)	115 (62.5)
Newborns
			AA	AG		GG			A	G
TaqI/A > G	Preterm	40	17 (42.5)	18 (45.0)	0.788	5 (12.5)	0.447	1.0	52 (65.0)	28 (35.0)	0.705
	Full-term	92	39 (42.4)	46 (50.0)		7 (7.6)		0.419	124 (67.5)	60 (32.5)
			CC	CT		TT			C	T
BsmI/C > T	Preterm	40	14 (35.0)	1 (2.5)	0.002	25 (62.5)	0.001	< 0.001	29 (36.3)	51 (63.7)	< 0.001
	Full-term	92	38 (41.3)	37 (40.2)		17 (18.5)		0.348	113 (61.4)	71 (38.6)
			CC	CA		AA			C	A
ApaI/C > A	Preterm	40	6 (15.0)	16 (40.0)	0.839	18 (45.0)	0.004	0.900	28 (35.0)	52 (65.0)	0.002
	Full-term	92	23 (25.0)	55 (59.8)		14 (15.2)		0.139	101 (54.9)	83 (45.1)
			AA	AG		GG			A	G
FokI/A > G	Preterm	40	1 (2.5)	19 (47.5)	0.109	20 (50.0)	0.037	0.358	21 (26.3)	59 (73.7)	0.053
	Full-term	92	12 (13.0)	47 (51.1)		33 (35.9)		0.757	71 (38.6)	113 (61.4)

SNV Single Nucleotide Variant described according to HGVS nomenclature, OR Odds Ratio;
CI Confidence Interval, HWE Hardy-Weinberg Equilibrium
*Chi-square test. Wild genotype as reference. P < 0.05

ISSN: 1471-2393