No association between early antiretroviral therapy during pregnancy and plasma levels of angiogenic factors: a cohort study

Table 3 Association between biomarkers and adverse birth outcomes

Biomarkers	Crude coefficient	CI (95%)	p-value	Adjusted coefficient^a	Adjusted CI (95%)	p-value
First trimester
PlGF
SGA	−0.006	−0.109 - 0.097	0.904	−0.023^b	− 0.130 - 0.085	0.980
Preterm birth	0.054	−0.046 - 0.154	0.290	0.056^c	−0.043 - 0.155	0.266
sFlt1
SGA	−0.192	−0.384 - 0.001	0.051	−0.260^d	− 0.432 - -0.088	0.003
Preterm birth	0.090	−0.100 - 0.280	0.350	0.064^d	−0.106 - 0.233	0.458
sFlt1/PlGF Ratio
SGA	−0.184	−0.415 - 0.048	0.119	−0.227^d	− 0.437 - -0.016	0.035
Preterm birth	0.035	−0.193 - 0.264	0.760	0.002^e	−0.207 - 0.211	0.986
Second trimester
PlGF
SGA	−0.096	−0.220 - 0.028	0.127	−0.117^f	− 0.225 - -0.010	0.033
Preterm birth	−0.071	−0.193 - 0.050	0.248	−0.006^g	− 0.113 - 0.100	0.909
sFlt1
SGA	0.007	−0.147 - 0.161	0.930	0.048^h	−0.121 - 0.216	0.576
Preterm birth	0.072	−0.082 - 0.226	0.920	−0.077ⁱ	−0.083 - 0.237	0.342
sFlt1/PlGF Ratio
SGA	0.107	−0.097 - 0.306	0.291	0.162^j	−0.038 - 0.362	0.111
Preterm birth	0.132	−0.067 - 0.331	0.193	0.013^k	−0.193 - 0.218	0.903

ART Antiretroviral therapy, CI Confidence interval, SGA Small for gestational age
^aLinear regression
^b Adjusted for gestational age at the date of test, maternal age, body mass index, parity, sex of the fetus and ART
^c Adjusted for gestational age at the date of test and ART
^dAdjusted for gestational age at the date of test, body mass index, sex of the fetus and ART
^eAdjusted for gestational age at the date of test, body mass index, ethnicity, parity, sex of the fetus and ART
^fAdjusted for gestational age at the date of test, maternal age, body mass index, ethnicity, parity, and ART
^gAdjusted for gestational age at the date of test, body mass index, ethnicity, parity, and ART
^hAdjusted for gestational age at the date of test, maternal age, body mass index, ethnicity, parity, smoking, sex of the fetus and ART
ⁱAdjusted for gestational age at the date of test, maternal age, smoking, sex of the fetus and ART
^jAdjusted for gestational age at the date of test, maternal age, body mass index, ethnicity, parity, smoking and ART
^kAdjusted for gestational age at the date of test, maternal age, body mass index, smoking, sex of the fetus and ART

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