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Table 4 Performance of this combined screening at fixed FPRs in PE and SGA subgroups

From: Early prediction of preeclampsia and small-for-gestational-age via multi-marker model in Chinese pregnancies: a prospective screening study

  FPR 5% FPR 10% FPR 15%
  DR % PPV % DR % PPV % DR % PPV %
Posterior Risk Early (< 34 weeks) risk cut-off (1:64) risk cut-off (1:172) risk cut-off (1:293)
Early PE (n = 8) 87.50 (47.35–99.68) 4.17 (1.69–8.40) 87.50 (47.35–99.68) 2.12 (0.86–4.32) 87.50 (47.35–99.68) 1.43 (0.58–2.92)
Early PE with SGA (n = 5) 100.00 (47.82–100.00) 3.01 (0.99–6.89) 100.00 (47.82–100.00) 1.52 (0.50–3.52) 100.00 (47.82–100.00) 1.02 (0.33–2.37)
Early PE with AGA (n = 3) 66.67 (9.43–99.16) 3.11 (1.04–7.03) 66.67 (9.43–99.16) 1.58 (0.53–3.60) 66.67 (9.43–99.16) 1.06 (0.35–2.42)
Early SGA (n = 24) 37.50 (18.80–59.41) 5.36 (2.48–9.93) 41.67 (22.11–63.36) 3.06 (1.48–5.55) 45.83 (25.55–67.18) 2.26 (1.13–4.01)
Early SGA without PE (n = 19) 21.05 (6.05–45.57) 2.45 (0.67–6.16) 26.32 (9.15–51.20) 1.55 (0.51–3.59) 31.58 (12.58–56.55) 1.24 (0.46–2.69)
Posterior Risk Late (≥34 weeks) risk cut-off (1:25) risk cut-off (1:48) risk cut-off (1:75)
Late PE (n = 35) 40.00 (23.87–57.89) 8.00 (4.44–13.06) 48.57 (31.38–66.01) 5.00 (2.94–7.88) 60.00 (42.11–76.13) 4.16 (2.59–6.29)
Late PE with SGA (n = 10) 60.00 (26.24–87.84) 3.59 (1.33–7.66) 60.00 (26.24–87.84) 1.82 (0.67–3.93) 70.00 (34.75–93.33) 1.43 (0.58–2.92)
Late PE with AGA (n = 25) 32.00 (14.95–53.50) 1.52 (0.25–4.79) 44.00 (24.40–65.07) 4.54 (2.58–7.34) 56.00 (34.93–75.60) 3.88 (2.37–5.96)
Late SGA (n = 75) 20.00 (11.65–30.83) 8.62 (4.91–13.82) 28.00 (18.24–39.56) 6.21 (3.89–9.34) 40.00 (28.85–51.96) 5.93 (4.04–8.36)
Late SGA without PE (n = 65) 13.85 (6.53–24.66) 5.36 (2.48–9.93) 23.08 (13.53–35.19) 4.52 (2.55–7.34) 35.38 (23.92–48.23) 4.61 (2.94–6.84)
  1. DR = Detection rate, FPR = False positive rate, PPV=Positive predictable value, 95% CI = 95% Confidence interval, PE = Preeclampsia, SGA = Small-for-gestational-age, AGA = Appropriate-for-gestational-age, n = number