Skip to main content

Table 4 Performance of this combined screening at fixed FPRs in PE and SGA subgroups

From: Early prediction of preeclampsia and small-for-gestational-age via multi-marker model in Chinese pregnancies: a prospective screening study

 

FPR 5%

FPR 10%

FPR 15%

 

DR %

PPV %

DR %

PPV %

DR %

PPV %

Posterior Risk Early (< 34 weeks)

risk cut-off (1:64)

risk cut-off (1:172)

risk cut-off (1:293)

Early PE (n = 8)

87.50 (47.35–99.68)

4.17 (1.69–8.40)

87.50 (47.35–99.68)

2.12 (0.86–4.32)

87.50 (47.35–99.68)

1.43 (0.58–2.92)

Early PE with SGA (n = 5)

100.00 (47.82–100.00)

3.01 (0.99–6.89)

100.00 (47.82–100.00)

1.52 (0.50–3.52)

100.00 (47.82–100.00)

1.02 (0.33–2.37)

Early PE with AGA (n = 3)

66.67 (9.43–99.16)

3.11 (1.04–7.03)

66.67 (9.43–99.16)

1.58 (0.53–3.60)

66.67 (9.43–99.16)

1.06 (0.35–2.42)

Early SGA (n = 24)

37.50 (18.80–59.41)

5.36 (2.48–9.93)

41.67 (22.11–63.36)

3.06 (1.48–5.55)

45.83 (25.55–67.18)

2.26 (1.13–4.01)

Early SGA without PE (n = 19)

21.05 (6.05–45.57)

2.45 (0.67–6.16)

26.32 (9.15–51.20)

1.55 (0.51–3.59)

31.58 (12.58–56.55)

1.24 (0.46–2.69)

Posterior Risk Late (≥34 weeks)

risk cut-off (1:25)

risk cut-off (1:48)

risk cut-off (1:75)

Late PE (n = 35)

40.00 (23.87–57.89)

8.00 (4.44–13.06)

48.57 (31.38–66.01)

5.00 (2.94–7.88)

60.00 (42.11–76.13)

4.16 (2.59–6.29)

Late PE with SGA (n = 10)

60.00 (26.24–87.84)

3.59 (1.33–7.66)

60.00 (26.24–87.84)

1.82 (0.67–3.93)

70.00 (34.75–93.33)

1.43 (0.58–2.92)

Late PE with AGA (n = 25)

32.00 (14.95–53.50)

1.52 (0.25–4.79)

44.00 (24.40–65.07)

4.54 (2.58–7.34)

56.00 (34.93–75.60)

3.88 (2.37–5.96)

Late SGA (n = 75)

20.00 (11.65–30.83)

8.62 (4.91–13.82)

28.00 (18.24–39.56)

6.21 (3.89–9.34)

40.00 (28.85–51.96)

5.93 (4.04–8.36)

Late SGA without PE (n = 65)

13.85 (6.53–24.66)

5.36 (2.48–9.93)

23.08 (13.53–35.19)

4.52 (2.55–7.34)

35.38 (23.92–48.23)

4.61 (2.94–6.84)

  1. DR = Detection rate, FPR = False positive rate, PPV=Positive predictable value, 95% CI = 95% Confidence interval, PE = Preeclampsia, SGA = Small-for-gestational-age, AGA = Appropriate-for-gestational-age, n = number