Characteristics | IVF | ICSI | ||||
---|---|---|---|---|---|---|
Fertile men (n = 28,671) | Subfertile men (n = 3163) | P valuee | Fertile men (n = 13,777) | Subfertile men (n = 14,360) | P valuee | |
Maternal age (y) | 35.1 ± 3.8 | 35.2 ± 3.8 | 0.43 | 35.8 ± 3.8 | 34.8 ± 3.9 | <.001 |
< 30 | 2275 (7.9) | 240 (7.6) | 0.84 | 783 (5.7) | 1395 (9.7) | <.001 |
30–34 | 9801 (34.2) | 1076 (34.0) | 3995 (29.0) | 4943 (34.4) | ||
35–39 | 13,091 (45.7) | 1466 (46.4) | 6584 (47.8) | 6411 (44.6) | ||
≥ 40 | 3504 (12.2) | 381 (12.1) | 2415 (17.5) | 1611 (11.2) | ||
Infertility diagnosisa | ||||||
Tubal factor | 6761 (23.6) | 432 (13.7) | <.001 | 2479 (18.0) | 1143 (8.0) | <.001 |
Endometriosis | 2756 (9.6) | 244 (7.7) | 0.001 | 1188 (8.6) | 660 (4.6) | <.001 |
Antisperm antibody | 232 (0.81) | 15 (0.47) | 0.04 | 170 (1.23) | 38 (0.26) | <.001 |
Other | 3507 (12.2) | 513 (16.2) | <.001 | 2513 (18.2) | 1700 (11.8) | <.001 |
Unexplained | 16,828 (58.7) | – | – | 8150 (59.2) | – | – |
Quality of semen for fertilization | (n = 26,056) | (n = 2902) | (n = 12,214) | (n = 11,796) | ||
Sperm concentration, (×106/mL) | 101.0 ± 462.6 | 71.3 ± 238.6 | <.001 | 66.9 ± 244.1 | 32.7 ± 80.9 | <.001 |
Total sperm motility, (%) | 58.4 ± 16.1 | 49.7 ± 18.5 | <.001 | 47.9 ± 19.8 | 34.7 ± 20.9 | <.001 |
Normal sperm | 22,418 (86.0) | 1901 (65.5) | <.001 | 7574 (62.0) | 2946 (25.0) | <.001 |
Oligozoospermiab | 447 (1.7) | 169 (5.8) | 761 (6.2) | 1772 (15.0) | ||
Asthenozoospermiab | 3050 (11.7) | 721 (24.8) | 2872 (23.5) | 3473 (29.4) | ||
Oligoasthenozoospermiab | 141 (0.54) | 111 (3.8) | 1007 (8.2) | 3605 (30.6) | ||
Embryo stage at transfer | ||||||
Early cleavage | 20,232 (70.6) | 2206 (69.7) | 0.34 | 9998 (72.6) | 9792 (68.2) | <.001 |
Blastocyst | 8439 (29.4) | 957 (30.3) | 3779 (27.4) | 4568 (31.8) | ||
Number of embryos transferredc | ||||||
One | 21,798 (76.0) | 2377 (75.2) | 0.55 | 10,160 (73.8) | 10,330 (71.9) | 0.002 |
Two | 6314 (22.0) | 723 (22.9) | 3359 (24.4) | 3767 (26.2) | ||
Three or more | 559 (2.0) | 63 (2.0) | 258 (1.9) | 263 (1.8) | ||
Yeard | ||||||
2007 | 3154 (49.1) | 335 (5.2) | 0.02 | 1232 (19.2) | 1707 (26.6) | <.001 |
2008 | 3299 (50.1) | 345 (5.2) | 1282 (19.5) | 1660 (25.2) | ||
2009 | 3687 (48.8) | 438 (5.8) | 1520 (20.1) | 1914 (25.3) | ||
2010 | 3537 (47.5) | 390 (5.2) | 1569 (21.1) | 1951 (26.2) | ||
2011 | 3494 (46.4) | 415 (5.5) | 1701 (22.6) | 1920 (25.5) | ||
2012 | 3782 (47.9) | 355 (4.5) | 2010 (25.4) | 1753 (22.2) | ||
2013 | 3793 (46.7) | 415 (5.1) | 2180 (26.8) | 1741 (21.4) | ||
2014 | 3925 (46.8) | 470 (5.6) | 2283 (27.2) | 1714 (20.4) |