Table 3 Risk of HDP in antidepressant and/or anxiolytic users before the 16th week of gestation according to class of medication

Unexposed (n = 6502)

1

1

Selective serotonin reuptake inhibitors (SSRI) (n = 103)

3.09 (1.22–7.85)

p = 0.018

0.75 (0.19–2.91)

p = 0.68

Serotonin norepinephrine reuptake inhibitors (SNRI) (n = 57)

6.46 (2.49–16.78)

p < 0.0001

2.83 (0.98–8.11)

p = 0.054

Benzodiazepine (benzo)(n = 26)

2.64 (0.41–16.86)

p = 0.31

0.44 (0.02–10.78)

p = 0.41

SSRI and benzo simultaneously (n = 10)

1.44 (0.03–64.19)

p = 0.85

2.35 (0.21–26.69)

p = 0.49

Tricyclic antidepressant (TCA) (n = 5)

7.36 (0.22–251.11)

p = 0.27

4.50 (0.13–159.47)

p = 0.41

Any Antidepressant and/or anxiolytic (n = 218)

3.09 (1.56–6.12)

p = 0.001

1.39 (0.66–2.92)

p = 0.38

Non medicated depression/anxiety during pregnancy (n = 41)

2.92 (0.67–12.73)

p = 0.15

0.77 (0.10–5.78)

p = 0.80