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Table 3 Gene variants included in the study

From: Non-additive effects of ACVR2A in preeclampsia in a Philippine population

Chr SNP Gene Product (processes involved in) MAF OR Allelic
P value
Genotypic
P value
1 rs1051740 EPHX1 Epoxide hydrolase (xenobiotic metabolism) 0.4547 1.039 0.8109 0.6148
1 rs699 AGT Angiotensinogen (products elicit vasoconstriction) 0.1277 1.098 0.6899 NA
1 rs1805087 MTR 5-Methyltetrahydrofolate-Homocysteine Methyltransferase (methionine biosynthesis) 0.1357 1.013 0.9568 NA
2 rs3783550 IL1A Interleukin 1-alpha (immunity, inflammation, hematopoiesis) 0.2031 1.003 0.988 0.7627
2 rs1014064 ACVR2A Activin A Receptor Type 2A (growth and differentiation) 0.4414 0.8699 0.3805 0.556
2 rs2161983 ACVR2A 0.4385 0.8921 0.4717 0.5188
2 rs231775 CTLA-4 Cytotoxic T-Lymphocyte Associated Protein 4 (inhibition of immune responses) 0.4462 1.22 0.216 0.4626
4 rs2960306 GRK4 G protein-coupled receptor kinase 4 (receptor desensitization) 0.0679 1.763 0.0709 NA
4 rs1024323 GRK4 0.1354 1.26 0.3133 NA
4 rs1801058 GRK4 0.4599 1.024 0.8797 0.8192
4 rs7664413 VEGF-C Vascular endothelial growth factor C (lymphangiogenesis) 0.2436 1.316 0.1412 0.181
5 rs1801394 MTRR Methionine synthase reductase (methionine biosynthesis) 0.2754 0.9219 0.645 0.8572
5 rs2549782 ERAP 2 Endoplasmic reticulum aminopeptidase 2 (antigen processing) 0.4046 1.097 0.5622 0.8404
5 rs4532 DRD1 Dopamine D1 receptor (sodium transport, blood pressure regulation) 0.2105 1.01 0.9594 0.9148
6 rs2010963 VEGF-A Vascular endothelial growth factor A (angiogenesis, vasculogenesis, endothelial cell growth & migration) 0.223 0.8585 0.4495 NA
6 rs3025039 VEGF-A 0.1188 0.6282 0.0626 NA
7 rs662 PON1 Paraoxonase 1 (inactivation of organophosphates, inhibition of atherosclerosis formation) 0.4306 0.9923 0.9612 0.9841
7 rs1799983 NOS3 Endothelial NOS (vascular relaxation, antioxidant activity) 0.1813 0.9324 0.7342 0.829
11 rs1695 GSTP1 Glutathione S-Transferase Pi 1 (xenobiotic metabolism) 0.2954 1.073 0.6809 0.8688
13 rs12584067 VEGFR-1 Vascular endothelial growth factor receptor 1 (cell proliferation and differentiation 0.0776 1.282 0.3978 NA
13 rs722503 VEGFR-1 Vascular endothelial growth factor receptor 1 (cell proliferation and differentiation 0.1660 0.8019 0.3593 NA
15 rs2470890 CYP1A2 Cytochrome P450 1A2 (xenobiotic metabolism) 0.0923 0.8182 0.4643 NA
22 rs4633 COMT Catechol-O-methyltransferase (degrades catecholamines) 0.1692 1.056 0.7962 NA
  1. Chr Chromosome, SNP Single nucleotide polymorphism, MAF Minor allele frequencies, OR Odds ratio, NA Not appplicable
  2. The alleles and genotypes of the SNPs are not associated with preeclampsia when analyzed using PLINK. NA corresponds to the inability to determine a genotypic P value, due to a small number of counts in at least 1 of the 3 genotypes (i.e., AA/AT/TT not present, only AA/AT), thus, only allelic P value is given.