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Table 3 Gene variants included in the study

From: Non-additive effects of ACVR2A in preeclampsia in a Philippine population

Chr

SNP

Gene

Product (processes involved in)

MAF

OR

Allelic

P value

Genotypic

P value

1

rs1051740

EPHX1

Epoxide hydrolase (xenobiotic metabolism)

0.4547

1.039

0.8109

0.6148

1

rs699

AGT

Angiotensinogen (products elicit vasoconstriction)

0.1277

1.098

0.6899

NA

1

rs1805087

MTR

5-Methyltetrahydrofolate-Homocysteine Methyltransferase (methionine biosynthesis)

0.1357

1.013

0.9568

NA

2

rs3783550

IL1A

Interleukin 1-alpha (immunity, inflammation, hematopoiesis)

0.2031

1.003

0.988

0.7627

2

rs1014064

ACVR2A

Activin A Receptor Type 2A (growth and differentiation)

0.4414

0.8699

0.3805

0.556

2

rs2161983

ACVR2A

0.4385

0.8921

0.4717

0.5188

2

rs231775

CTLA-4

Cytotoxic T-Lymphocyte Associated Protein 4 (inhibition of immune responses)

0.4462

1.22

0.216

0.4626

4

rs2960306

GRK4

G protein-coupled receptor kinase 4 (receptor desensitization)

0.0679

1.763

0.0709

NA

4

rs1024323

GRK4

0.1354

1.26

0.3133

NA

4

rs1801058

GRK4

0.4599

1.024

0.8797

0.8192

4

rs7664413

VEGF-C

Vascular endothelial growth factor C (lymphangiogenesis)

0.2436

1.316

0.1412

0.181

5

rs1801394

MTRR

Methionine synthase reductase (methionine biosynthesis)

0.2754

0.9219

0.645

0.8572

5

rs2549782

ERAP 2

Endoplasmic reticulum aminopeptidase 2 (antigen processing)

0.4046

1.097

0.5622

0.8404

5

rs4532

DRD1

Dopamine D1 receptor (sodium transport, blood pressure regulation)

0.2105

1.01

0.9594

0.9148

6

rs2010963

VEGF-A

Vascular endothelial growth factor A (angiogenesis, vasculogenesis, endothelial cell growth & migration)

0.223

0.8585

0.4495

NA

6

rs3025039

VEGF-A

0.1188

0.6282

0.0626

NA

7

rs662

PON1

Paraoxonase 1 (inactivation of organophosphates, inhibition of atherosclerosis formation)

0.4306

0.9923

0.9612

0.9841

7

rs1799983

NOS3

Endothelial NOS (vascular relaxation, antioxidant activity)

0.1813

0.9324

0.7342

0.829

11

rs1695

GSTP1

Glutathione S-Transferase Pi 1 (xenobiotic metabolism)

0.2954

1.073

0.6809

0.8688

13

rs12584067

VEGFR-1

Vascular endothelial growth factor receptor 1 (cell proliferation and differentiation

0.0776

1.282

0.3978

NA

13

rs722503

VEGFR-1

Vascular endothelial growth factor receptor 1 (cell proliferation and differentiation

0.1660

0.8019

0.3593

NA

15

rs2470890

CYP1A2

Cytochrome P450 1A2 (xenobiotic metabolism)

0.0923

0.8182

0.4643

NA

22

rs4633

COMT

Catechol-O-methyltransferase (degrades catecholamines)

0.1692

1.056

0.7962

NA

  1. Chr Chromosome, SNP Single nucleotide polymorphism, MAF Minor allele frequencies, OR Odds ratio, NA Not appplicable
  2. The alleles and genotypes of the SNPs are not associated with preeclampsia when analyzed using PLINK. NA corresponds to the inability to determine a genotypic P value, due to a small number of counts in at least 1 of the 3 genotypes (i.e., AA/AT/TT not present, only AA/AT), thus, only allelic P value is given.
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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