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Table 3 Diagnostic performance of each analyte to predict <10th and < 3rd centile infants, and preeclampsia

From: Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks’ gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

Outcome Analyte and cut-point Sensitivity Specificity PPV NPV
Birthweight < 10th centile (All SGA) sFlt-1 > 4570 pg/ml 19.6%
[12.4–28.6%]
89.9%
[84.9–93.6%]
18.0%
[11.1–27.9%]
90.8%
[89.8–91.6%]
PlGF < 117.3 pg/ml 28.8%
[20.4–38.6%]
89.5%
[84.6–93.3%]
24.2%
[16.3–34.5%]
91.6%
[90.5–92.5%]
sFlt-1:PlGF > 33.4 26.5%
[18.2–36.1%]
89.9%
[84.9–93.6%]
22.9%
[15.0–33.2%]
91.5%
[90.5–92.4%]
Birthweight < 10th centile (SGA only) sFlt-1 > 4570 pg/ml 16.8%
[9.9–25.9%]
89.9%
[84.9–93.6%]
14.8%
[8.7–24.2%]
91.1%
[90.3–91.9%]
PlGF < 117.3 pg/ml 24.7%
[16.5–34.5%]
89.5%
[84.6–93.3%]
20.2%
[13.0–30.0%]
91.7%
[90.7–92.6%]
sFlt-1:PlGF > 33.4 22.1%
[14.2–31.8%]
89.9%
[84.9–93.6%]
18.6%
[11.6–28.5%]
91.7%
[90.7–92.5%]
Birthweight < 3rd centile (All SGA) sFlt-1 > 4570 pg/ml 21.4%
[8.3–41.0%]
87.5%
[83.1–91.2%]
4.7%
[2.2–9.7%]
97.5%
[96.9–97.9%]
PlGF < 117.3 pg/ml 32.1%
[15.9–52.4%]
85.0%
[80.3–88.9%]
5.8%
[3.3–10.1%]
97.8%
[97.1–98.3%]
sFlt-1:PlGF > 33.4 28.6%
[13.2–48.7%]
85.8%
[81.1–89.6%]
5.5%
[2.9–10.0%]
97.7%
[97.0–98.1%]
Birthweight < 3rd centile (SGA only) sFlt-1 > 4570 pg/ml 22.2%
[8.6–42.3%]
88.7%
[84.4–92.2%]
5.2%
[2.4–10.7%]
97.6%
[97.1–98.1%]
PlGF < 117.3 pg/ml 29.6%
[13.8–50.2%]
86.4%
[81.9–90.2%]
5.7%
[3.1–10.4%]
97.8%
[97.2–98.3%]
sFlt-1:PlGF > 33.4 25.9%
[11.1–46.3%]
87.3%
[82.7–91.0%]
5.4%
[2.7–10.3%]
97.7%
[97.1–98.2%]
Preeclampsia sFlt-1 > 4570 pg/ml 56.4%
[39.6–72.2%]
89.9%
[84.9–93.6%]
18.4%
[12.1–26.9%]
98.1%
[97.3–98.6%]
PlGF < 117.3 pg/ml 64.1%
[47.2–78.8%]
89.5%
[84.6–93.3%]
19.9%
[13.6–28.2%]
98.4%
[97.6–98.9%]
sFlt-1:PlGF > 33.4 69.2%
[52.4–83.0%]
89.9%
[84.9–93.6%]
21.7%
[14.9–30.4%]
98.6%
[97.8–99.1%]
  1. Data presented with [95% Confidence Interval]. *determined by a false positive rate of 10% in the birthweight ≥10th centile and no preeclampsia control group. “All SGA” = Cases of SGA fetuses including cases with co-existent preeclampsia; “SGA only” = Cases of SGA fetuses with cases of co-existant preeclampisa excluded; NPV Negative Predictive value, pg/ml = pictogram/millilitre, PlGF placental growth factor, PPV Positive Predictive Value, sFlt-1 soluble fms-like tyrosine kinase-1, SGA small-for-gestational-age