Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks’ gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

Table 2 sFlt-1, PlGF and sFlt-1:PlGF ratios compared between controls and: (i) cases with a SGA infant; (ii) preeclampsia cases

	Controls	All SGA	P	SGA only	P	Preeclampsia	P
sFlt-1 (pg/ml)	2446 [1795–3503]	2837 [1850–4250]	0.02	2620 [1835–4099]	0.10	4857 [3777–6941]	< 0.001
PlGF (pg/ml)	326.7 [173.1–675.4]	178.5 [106.4–404.8]	< 0.001	199.9 [118.1–448.6]	< 0.001	99.73 [61.99–158.6]	< 0.001
sFlt-1:PlGF ratio	7.11 [3.08–15.58]	14.24 [6.00–37.37]	< 0.001	13.00 [5.27–32.44]	< 0.001	54.25 [26.81–114.5]	< 0.001

Data presented as median [25th–75th percentile]. “All SGA” = Cases with a SGA fetuses including cases with co-existent preeclampsia; “SGA only” = Cases with SGA fetuses with cases of co-existant preeclampisa excluded; pg/ml = picogram/millilitre, PlGF placental growth factor, sFlt-1 soluble fms-like tyrosine kinase-1, SGA small-for-gestational-age (birthweight <10th centile). For sFlt-1 and sFlt-1:PlGF ratio results n = 207 for controls, n = 102 for ‘All SGA’, n = 39 for ‘Preeclampsia’. For PlGF results n = 210 for controls, n = 104 for ‘All SGA’, and n = 39 for ‘Preeclampsia’

ISSN: 1471-2393