The effectiveness of an online intervention in preventing excessive gestational weight gain: the e-moms roc randomized controlled trial

Table 4 Sensitivity analyses for excessive total gestational weight gain (GWG) and excessive weekly GWG

Sensitivity Sample	Outcome	Intervention^a	Placebo control^a	Adjusted estimate^b (95% CI)	P-value
Eligible and participating sample^c	Excessive total GWG	47.6% (1.7%)	45.9% (2.4%)	1.10 (0.98, 1.22)	0.09
Eligible and participating sample^c	Excessive weekly GWG	66.8% (1.6%)	68.9% (2.3%)	0.99 (0.93, 1.07)	0.85
Complete case sample^d	Excessive total GWG	47.0%	45.1%	1.11 (1.00, 1.24)	0.06
Complete case sample^d	Excessive weekly GWG	67.0%	68.4%	1.01 (0.94, 1.08)	0.85
Per-protocol sample^e	Excessive total GWG	45.5% (2.3%)	41.6% (3.6%)	1.14 (0.96, 1.37)	0.14
Per-protocol sample^e	Excessive weekly GWG	64.2% (2.2%)	62.2% (3.7%)	1.07 (0.95, 1.20)	0.28
As treated sample^f	Excessive total GWG	47.4% (1.8%)	46.6% (2.2%)	1.08 (0.97, 1.2)	0.15
As treated sample^f	Excessive weekly GWG	66.6% (1.7%)	68.8% (2.0%)	1.00 (0.93, 1.07)	0.89
Self-reported pre-pregnancy weight^g	Excessive total GWG	53.9% (1.9%)	53.1% (2.4%)	1.05 (0.96, 1.15)	0.26
Self-reported pre-pregnancy weight^g	Excessive weekly GWG	Not applicable	Not applicable	Not applicable	Not applicable
Not excessive GWG at start of treatment^h	Excessive total GWG	42.8% (2.0%)	39.3% (2.7%)	1.12 (0.96, 1.30)	0.15
Not excessive GWG at start of treatment^h	Excessive weekly GWG	65.6% (2.0%)	66.3% (2.6%)	1.02 (0.93, 1.11)	0.68

^aResults are pooled across imputed data sets (except for the complete case sample) and are not adjusted for other factors, [Mean % (SD)]
^bRelative Risk (RR) estimates of excessive GWG from log-binomial model for intervention vs placebo adjusted for strata, gestational age at delivery, continuous BMI, and two timing of weight measurements variables. The COPY method was used if any of the 60 log-binomial models did not converge
^cEligible and participating sample: N = 1335; Intervention arm (n = 898), Placebo control arm (n = 437)
^dComplete case sample for excessive total GWG: N = 1337; Intervention arm (n = 891), Placebo control arm (n = 446). Complete case sample for excessive weekly GWG rate: N = 1364; Intervention arm (n = 912), Placebo control arm (n = 452)
^ePer protocol sample comprised of subjects who logged into website within each 45 day interval of participation: N = 714; Intervention arm (n = 519), Placebo control arm (n = 195)
^fThe as treated sample moves all those in the intervention arm who did not login or when they logged in, did not view the behavior change tools to the placebo control condition: N = 1335; Intervention arm (n = 788), Placebo control arm (n = 547)
^gITT sample with excessive GWG determined using self-reported pre-pregnancy weight rather than first measured weight ≤ 14 weeks gestation
^hITT sample not excessive GWG by first login to website (nearest weight within 6 weeks): N = 1055; Intervention arm (n = 709), Placebo control arm (n = 346)

ISSN: 1471-2393