Table 3 Results by genus (study is included if it includes at least one strain of that genus) for primary and key secondary outcomes in systematic review of the use of probiotics and/or prebiotics during pregnancy
From: Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis
Outcome | Intervention | Studies | N | I2 | RR/MD (95% CI) |
|---|---|---|---|---|---|
PTB < 34 | Lactobacillus (& other) | 5 | 1017 | 0% | RR 1.03 (0.29–3.64) |
|  | Bifidobacterium (& other) | 3 | 377 | 0% | RR 1.54 (0.27–8.73) |
|  | Streptococcus (& other) | 2 | 146 | 0% | RR 1.60 (0.20–12.69) |
PTB < 37 | Lactobacillus (& other) | 10 | 2328 | 0% | RR 1.10 (0.72–1.68) |
|  | Bifidobacterium (& other) | 7 | 1479 | 0% | RR 1.21 (0.75–1.96) |
|  | Streptococcus (& other) | 3 | 512 | 0% | RR 1.81 (0.80–4.10) |
Gestational age (weeks) | Lactobacillus (& other) | 8 | 1133 | 0% | MD 0.07 weeks (-0.09–0.23) |
|  | Bifidobacterium (& other) | 3 | 365 | 0% | MD 0.30 weeks (0.03–0.57) |
|  | Streptococcus (& other) | 1 | 66 | – | MD 0.40 weeks (-0.10–0.90) |
Birth weight (grams) | Lactobacillus (& other) | 10 | 1608 | 0% | MD 10.66 g (-35.85–57.18) |
|  | Bifidobacterium (& other) | 5 | 840 | 0% | MD 22.44 g (-40.58–85.46) |
|  | Streptococcus (& other) | 1 | 66 | – | MD -65.00 g (-301.73–171.73) |
SGA | Lactobacillus (& other) | 3 | 318 | 50% | RR 1.03 (0.35–3.06) |
|  | Bifidobacterium (& other) | 1 | 66 | – | RR 11.00 (0.63–191.27) |
|  | Streptococcus (& other) | 1 | 66 | – | RR 11.00 (0.63–191.27) |
LGA | Lactobacillus (& other) | 3 | 316 | 0% | RR 0.96 (0.47–1.94) |
|  | Bifidobacterium (& other) | 1 | 66 | – | RR 0.67 (0.12–3.73) |
|  | Streptococcus (& other) | 1 | 66 | – | RR 0.67 (0.12–3.73) |
GDM | Lactobacillus (& other) | 2 | 355 | 0% | RR 1.25 (0.61–2.56) |
|  | Bifidobacterium (& other) | 1 | 219 | – | RR 1.26 (0.56–2.83) |
|  | Streptococcus (& other) | 0 | – | – | Not estimable |
PPROM | Lactobacillus (& other) | 2 | 366 | 0% | RR 1.37 (0.63–2.99) |
|  | Bifidobacterium (& other) | 2 | 366 | 0% | RR 1.37 (0.63–2.99) |
|  | Streptococcus (& other) | 2 | 366 | 0% | RR 1.37 (0.63–2.99) |