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Table 2 Risk (OR) of overall congenital malformations according to characteristics of fever in 1st trimester

From: Fever in pregnancy and the risk of congenital malformations: a cohort study

  N N
Cases
Congenital Malformations
OR Crude [95% CI]
Congenital Malformations
Adjusted* OR [95% CI]
Fever
 No 69,023 2574 1 [Ref] 1 [Ref]
 Yes 8321 302 0.97 [0.86–1.10] 0.99 [0.88 1.12]
Gestational age at fever incidents
 No fever 69,023 2574 1 [Ref] 1 [Ref]
 Pregnancy week 1–4 1032 43 1.12 [0.82–1.52] 1.13 [0.83–1.54]
 Pregnancy week 5–8 3407 124 0.98 [0.81–1.17] 0.99 [0.83–1.19]
 Pregnancy week 9–12 3882 135 0.93 [0.78–1.11] 0.95 [0.79–1.13]
Maximum temperature
 No fever 69,023 2574 1 [Ref] 1 [Ref]
  < 39.0 ° C 2613 108 1.11 [0.91–1.35] 1.12 [0.91–1.36]
  ≥ 39.0 ° C 2562 98 1.03 [0.84–1.26] 1.06 [0.86–1.30]
 Unknown 3146 96 0.81 [0.66–1.00] 0.82 [0.67–1.01]
Duration of fever episode
 No fever 69,023 2574 1 [Ref] 1 [Ref]
 1 day 1647 55 0.89 [0.68–1.17] 0.90 [0.69–1.18]
 2–3 days 4799 180 1.01 [0.86–1.17] 1.02 [0.88–1.19]
  + 4 days 1873 67 0.96 [0.75–1.23] 0.98 [0.76–1.25]
 Unknown 2 0 .. ..
  1. The Danish National Birth Cohort 1996–2002
  2. *Adjusted for parity, previous spontaneous abortion, maternal age at conception, IVF, diabetes mellitus, medical treatment of maternal epilepsy, rheumatoid arthritis, binge drinking in first trimester, smoking during pregnancy, and socio-occupational status