Table 2 Comparison of sensitivity, specificity, PPV, and NPV between Pilot and Validation cohorts for progesterone at cut-off < 35 nmol/L for high risk of miscarriage before 16th week of pregnancy

Sensitivity

0.767

(0.577, 0.901)

23/30

0. 657

(0.534, 0.767)

46/70

0.349

0.110

(-0.093, 0.274)

Specificity

0.888

(0.803, 0.945)

79/89

0. 920

(0.881, 0.949)

253/275

0.389

-0.032

(-0.119, 0.031)

PPV

0.697 ^a

(0.513, 0.844)

23/33

0. 677 ^b

(0.552, 0.785)

46/68

1.000

0.021

(-0.177, 0.196)

NPV

0. 919 ^a

(0.839, 0.967)

79/86

0. 913 ^b

(0.874, 0.944)

253/277

1.000

0.005

(-0.077, 0.062)

LR+

6.82

8.21

LR-

0.26

0.37