Table 3 Median and IQR of prolonged pain (EDIN) after delivery, acute pain (BPSN) before/after heel prick at day 2 to 3 of life, and duration of crying after heel prick (p-values test difference between all groups)
Variable | Plastic cup “Kiwi” | Metal cup | P | ||
|---|---|---|---|---|---|
Placebo | Paracetamol | Placebo | Paracetamol | ||
EDIN AUC | 24 (15–34) | 29 (2–50) | 43 (20–72) | 48 (32–66) | .02 |
EDIN (median, IQR) | |||||
2 h | 2 (1–3) | 2 (1–5) | 3 (0–5) | 3 (2–5) | .34 |
4 h | 1 (0–1) | 1 (0–4) | 1 (0–2) | 1 (0–2) | .55 |
8 h | 1 (0–1) | 1 (0–2) | 2 (0–4) | 2 (1–3) | <.00 |
12 h | 1 (0–2) | 1 (0–2) | 2 (0–4) | 2 (1–4) | .28 |
24 h | 0 (0–1) | 1 (0–3) | 2 (0–4) | 2 (1–4) | .03 |
EDIN ≥ 5 (%) | |||||
2 h | 11.1 | 34.6 | 28 | 28.2 | .37 |
4 h | 5.6 | 15.4 | 15.9 | 12.7 | .69 |
8 h | 11.1 | 0 | 19.5 | 14.1 | .1 |
12 h | 0 | 7.7 | 3.7 | 9.9 | .27 |
24 h | 0 | 7.7 | 19.5 | 18.3 | .12 |
BPSN (nurses) | |||||
before heel prick | 0 (0–2) | 0 (0–1) | 0 (0–1) | 0 (0–2) | .66 |
after heel prick | 3 (0–7) | 5 (4–9) | 3 (1–5) | 4 (2–7) | .07 |
BPSN (reviewer) | |||||
before heel prick | 0 (0–0) | 0 (0–1) | 0 (0–1) | 0 (0–1) | .7 |
after heel prick | 3 (2–9) | 5 (3–7) | 3 (2–6) | 5 (3–8) | .43 |
Salivary cortisol levels (nmol/L) | |||||
- before heel prick (n = 58) | 6.1 (3.7–8.4) | 5.1 (4.4–6.8) | 3.9 (2.3–7.7) | 4.1 (2.5–5.9) | .56 |
- after heel prick (n = 52) | 13.2 (8.6–16) | 18.9 (4.5–24.2) | 8.1 (4.5–25.4) | 10.5 (6.6–17.3) | .93 |
Duration of crying (sec) | 3 (0–86) | 22 (0–61) | 0 (0–23) | 16 (0–61) | .27 |