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Table 1 First prenatal test, time of diagnosis and pregnancy outcome according to year of birth in cases with a common trisomy (T21, T18, T13)

From: The impact of national prenatal screening on the time of diagnosis and outcome of pregnancies affected with common trisomies, a cohort study in the Northern Netherlands

 

Year of birth

2005–2006

2007–2009

2010–2012

Total

First prenatal test*

 PNS1

47

37%

72

39%

87

46%

206

41%

 PNS2

4

3%

52

28%

57

30%

113

22%

 PND

29

23%

23

12%

14

7%

66

13%

 No PNS or PND

48

38%

40

21%

30

16%

118

23%

Time of diagnosis**

 Postnatally

52

41%

79

42%

71

38%

202

40%

 Prenatally < 24 weeks

64

50%

104

56%

108

57%

276

55%

 Prenatally > = 24 weeks

12

9%

4

2%

9

5%

25

5%

Pregnancy outcome***

 Live birth

55

43%

79

42%

76

40%

210

42%

 Fetal death

14

11%

15

8%

24

13%

53

11%

 TOP

59

46%

93

50%

88

47%

240

48%

  1. T21 trisomy 21, T18 trisomy 18, T13 trisomy 13, PNS1 prenatal screening in first trimester, PNS2 prenatal screening in second trimester, PND prenatal diagnosis, TOP termination of pregnancy
  2. *X 2 = 60.2, p < 0.001; X2 for trend = 23.5, p < 0.01
  3. **X 2 = 9.3, p = 0.054
  4. ***X 2 = 2.4, p = 0.658