Hyperemesis gravidarum and placental dysfunction disorders

Table 3 Hyperemesis gravidarum severity groups and neonatal outcome

	Values	Crude model		Adjusted model^a
	Values	Coefficients (95% CI)^b	p	Coefficients (95% CI)^b	p
Birthweight (g)^c,d
No HG	3100 (476.6)	Reference		Reference
Mild HG	3116 (464.4)	16.36 (-44.82; 77.54)	0.60	-4.17 (-68.36; 60.02)	0.90
Severe HG	3046 (485.7)	-53.86 (-211.15; 103.43)	0.50	-171.72 (-333.26; -10.18)	0.04
SGA^c
No HG	212 (16.6)	Reference		Reference
Mild HG	54 (19.8)	1.24 (0.89; 1.73)	0.20	1.29 (0.87; 1.91)	0.20
Severe HG	6 (17.6)	1.08 (0.44; 2.64)	0.87	1.74 (0.68; 4.44)	0.25
LBW^c
No HG	101 (7.4)	Reference		Reference
Mild HG	21 (7.5)	1.03 (0.63; 1.67)	0.92	1.36 (0.74; 2.51)	0.32
Severe HG	2 (5.6)	0.74 (0.18; 3.13)	0.68	1.44 (0.33; 6.33)	0.63
Gestational age at delivery (in days)^e
No HG	274 (17)	Reference		Reference
Mild HG	275 (13)	0.27 (-2.22; 2.75)	0.83	-0.03 (-2.60; 2.54)	0.98
Severe HG	276 (19)	0.48 (-5.99; 6.96)	0.88	-2.20 (-8.81; 4.42)	0.52
Apgar score^c,e
No HG	9 (0)	Reference		Reference
Mild HG	9 (0)	-0.06 (-0.17; 0.04)	0.24	-0.08 (-0.19; 0.03)	0.15
Severe HG	9 (0)	-0.06 (-0.35; 0.23)	0.67	-0.09 (-0.39; 0.21)	0.56

Abbreviations: CI confidence interval, HG hyperemesis gravidarum, g grams, LBW low birthweight, SGA small for gestational age
^aAdjusted model: adjusted for socio-economic status (as reflected by income), smoking status, gravidity, maternal age and pre-pregnancy BMI
^bResults are expressed as linear regression coefficients (95% CI) in continuous outcomes or OR (95% CI) from logistic regression in case of dichotomous outcomes
^cMultiple pregnancies, stillbirths and miscarriages were excluded from the analyses
^dValues are reported as mean and standard deviation (SD)
^eValues are reported as median and inter-quartile range (IQR)

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