First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with pre-eclampsia: a case control study

Table 3 Area under the curve (AUC) values for MoM values of the markers

	PE n = 98	Early-onset (<34 wk) PE n = 13^{a, a1}	Preterm (<37 wk) PE n = 24^a	SGA and PE n = 20^a
PlGF
AUC	0.558	0.692^b	0.680^b	0.653^b
95% CI	0.486–0.705	.0.557–0.826	0.572–0.7880	0.519–0.788
%hCG-h
AUC	0.636^c	0.764^b	0.699^b	0.682^b
95% CI	0.566–0.705	0.622–0.907	0.577–0.821	0.550–0.815
PAPP-A
AUC	0.580^b	0.783^b	0.714^b	0.634^b
95% CI	0.507–0.653	0.656–0.910	0.612–0.849	0.500–0.769
PlGF, %hCG-h, PAPP-A^d
AUC	0.689^c	0.885^c	0.830^c	0.747^c
95% CI	0.622–0.756	0.804–0.966	0.747–0.913	0.624–0.869
PAPP-A, PlGF, MAP, nulliparity^d
AUC	0.750^c	0.810^c	0.756^c	0.826^c
95% CI	0.689–0.811	0.682–0.938	0.651–0.861	0.733–0.919
%hCG-h, PAPP-A, MAP, nulliparity^d
AUC	0.776^c	0.868^c	0.803^c	0.843^c
95% CI	0.717–0.834	0.749–0.986	0.696–0.910	0.760–0.925
%hCG-h,PAPP-A, PlGF, MAP, nulliparity^d
AUC	0.776^c	0.870^c	0.805^c	0.845^c
95% CI	0.718–0.835	0.753–0.988	0.699–0.912	0.763–0.927
%hCG-h, PAPP-A, PlGF, MAP, nulliparity, age, BMI, smoking^d
AUC	0.779^c	0.864^c	0.806^c	0.854^c
95% CI	0.721–0.837	0.740–0.988	0.697–0.914	0.771–0.937

PE pre-eclampsia, early-onset PE diagnosis made < 34 weeks of gestation, preterm PE diagnosis made < 37 weeks of gestation, SGA small-for-gestational-age (sex- and age –adjusted birth weight < 10^th percentile), CI confidence interval, MAP mean arterial pressure, BMI body mass index
^aSome patients may belong to more than one of these subgroups. ^a1Women with early-onset pre-eclampsia are included in the subgroup of preterm pre-eclampsia. ^bP < 0.05 or ^cP < 0.001 as compared to controls by ROC analysis. ^d Based on a risk calculation derived from logistic regression analysis

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