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Table 2 Perinatal Outcomes of the RPGEH Prenatal Cohort Participants Compared to Non-Participants in Kaiser Permanente Northern California

From: The Kaiser Permanente Northern California research program on genes, environment, and health (RPGEH) pregnancy cohort: study design, methodology and baseline characteristics

  Overall Denominator (n = 80,086) Participants (n = 14,757) Non-Participants (n = 65,329)
Perinatal Outcome   N (%)  
Preeclampsia
 None 71,368 (89.1) 13,017 (88.2) 58,315 (89.3)
 Pre-existing hypertension 2,441 (3.1) 524 (3.4) 1,917 (2.9)
 Gestational hypertension 3,079 (3.8) 604 (4.1) 2,475 (3.8)
 Preeclampsia/Eclampsia 3,198 (4.0) 612 (4.1) 2,586 (4.0)
Glucose Tolerance Status
 Normal Screening 56,461 (70.5) 10,861 (73.6) 45,599 (69.8)
 Abnormal Screening 12,013 (15.0) 2,125 (14.4) 9,930 (15.2)
 Gestational Diabetes 5,366 (6.7) 959 (6.5) 4,508 (6.9)
 Preexisting T2DM 961 (1.2) 162 (1.1) 784 (1.2)
 Not Screened 4,805 (6.4) 649 (4.4) 4,508 (6.9)
Gestational Age
  < 37 weeks 6,063 (7.6) 1,095 (7.4) 4,968 (7.6)
  ≥ 37 weeks 74,005 (92.4) 13,662 (92.6) 60,343 (92.4)
 Unknown 18 (<0.1) 0 (0) 18 (<0.1)
Gestational Age
 Extreme Preterm (<28 weeks) 324 (0.4) 57 (0.4) 267 (0.4)
 Severe Preterm (28–31 week) 526 (0.7) 91 (0.6) 435 (0.7)
 Moderate Preterm (32–33 weeks) 698 (0.9) 116 (0.8) 582 (0.9)
 Late Preterm (34–36 weeks) 4,515 (5.6) 831 (5.6) 3,684 (5.6)
  ≥ 37 weeks 74,005 (92.4) 13,662 (92.6) 60,343 (92.4)
 Unknown 18 (<0.1) 0 (0) 18 (<0.1)
Gestational weight gain in relation to the IOM weight gain guidelines
 Below 10,456 (13.1) 1,847 (12.5) 8,609 (13.2)
 Met 17,196 (21.5) 3,115 (21.1) 14,081 (21.6)
 Exceeded 48,689 (60.8) 9,416 (63.8) 39,273 (60.1)
 Unknown 3,745 (4.7) 379 (2.6) 3,366 (5.2)
 Infant birth weight (grams)a 3,361 ± 556 3,400 ± 565 3,350 ± 553
 AGA 63,843 (81.4) 11,771 (81.3) 52,072 (81.4)
 SGA 7,436 (9.5) 1,339 (9.3) 6,097 (9.5)
 LGA 6,992 (8.9) 1,342 (9.3) 5,650 (8.8)
 Unknown 135 (0.2) 17 (0.1) 118 (0.2)
Infant birth weight (grams)
 Very low birth weight (<1,500) 605 (0.8) 106 (0.7) 499 (0.8)
 Low birth weight (1,500–2,500) 3,158 (4.0) 555 (3.8) 2,603 (4.1)
 Normal birth weight (2,501–3,999) 65,975 (84.2) 12,042 (83.2) 53,933 (84.4)
 Macrosomia (4,000+) 8,582 (10.9) 1,757 (12.2) 6,825 (10.7)
 Unknown 86 (0.1) 9 (0.1) 77 (0.1)
NICU Stay
 Non-NICU 71,563 (89.4) 13,092 (88.7) 58,471 (89.5)
 NICU 8,393 (10.5) 1,647 (11.2) 6,746 (10.3)
 Delivery room death 112 (0.1) 17 (0.1) 95 (0.2)
 Unknown 18 (<0.1) 1 (<0.1) 17 (<0.1)
  1. aLGA is large-for-gestational age, adjusted for race/ethnicity
  2. SGA is small-for-gestational age, adjusted for race/ethnicity
  3. AGA is appropriate for-gestational age, adjusted for race/ethnicity