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Fig. 2 | BMC Pregnancy and Childbirth

Fig. 2

From: Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

Fig. 2

Effect of statins on sFlt-1 secretion and sFlt-1 e15a and i13 mRNA expression from placental tissues. a Simvastatin (0, 5, 50, 100 μM), rosuvastatin (0, 50, 100, 200, 300 μM) and pravastatin (0, 20, 200, 2000 μM) reduce sFlt-1 secretion from primary trophoblasts. b Inhibitory concentration of simvastatin, rosuvastatin and pravastatin was determined. c Simvastatin (100 μM) and pravastatin (2000 μM) significantly reduced sFlt-1 secretion from placental explants obtained from patients with preterm preeclampsia however rosuvastatin had no effect. d Pravastatin reduced sFlt-1 e15a mRNA expression from placental explants whilst simvastatin and rosuvastatin had no effect. Data represents n = 3-4 separate experiments and is expressed as mean ± SEM. Dark blue bars = control, light blue bars = statin treatments. a = p < 0.05, b = p < 0.01, d = p < 0.0001

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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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