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Table 3 Outcomes from the births of all women who gave birth at home (or family/TBA home). Data on haemoglobin is taken from those for whom a follow-up assessment was completed within 5 days of delivery

From: The MamaMiso study of self-administered misoprostol to prevent bleeding after childbirth in rural Uganda: a community-based, placebo-controlled randomised trial

Haemoglobin Measures (women seen within 5 days of delivery)

 

Misoprostol (n = 97)

Placebo (n = 80)

Relative risk or mean difference (95 % CI)

Days from birth to follow-up (mean, (SD))

3.6 (0.7)

3.5 (0.7)

0.07 (−0.14 : 0.28)

Fall in Hb >20 % (n, %)

9 ( 9.4)

6 ( 7.5)

1.110 (0.717 : 1.719)

Fall in Hb > 2 g/dl (n, %)

13 (13.4)

8 (10.0)

1.150 (0.798 : 1.657)

Postnatal Hb g/dl (mean (SD) [range])

11.1 (1.8) [5.2:15.3]

11.2 (1.4) [6.1:14.0]

−0.11 (−0.59 : 0.37)

Anaemia status* (n,%)

Normal

51 (52.6)

46 (57.5)

---

Mild

36 (37.1)

28 (35.0)

1.070 (0.803 : 1.426)

Moderate

8 ( 8.2)

5 ( 6.2)

1.170 (0.732 : 1.872)

Severe

2 ( 2.1)

1 ( 1.2)

1.268 (0.557 : 2.885)

Fall in Hb g/dl (mean (SD) [range])

0.06 (1.82) [−5.5:5.2]

0.09 (1.50) [−3.5:4.0]

−0.03 (−0.53 : 0.47)

Maternal and Neonatal Outcomes (all home births)

 

Misoprostol (n = 150)

Placebo (n = 149)

Relative risk or mean difference (95 % CI)

Days from birth to follow-up (median (IQR))

4 (3 – 13)

5 (3 – 25)

---

Maternal complications (n, %)

Health professional consulted

2 ( 1.3)

3 ( 2.0)

0.795 (0.525 : 1.427)

Admitted to a health facility >24 hours**

1 ( 0.7)

1 ( 0.7)

0.997 (0.517 : 1.691)

Surgical procedure since delivery***

0

1 ( 0.7)

---

Retained placenta

3 ( 2.0)

2 ( 1.3)

1.200 (0.581 : 2.477)

Blood transfusion after delivery

0

0

---

Use of additional uterotonics (n, %)

3 (2.0)

4 (2.7)

0.745 (0.189 : 2.928)

Self-reported side effects (n, %)

Shivering/chills after birth

75 (51.0)

40 (27.8)

1.594 (1.277 : 1.991)

Fever after birth

40 (27.2)

21 (14.6)

1.410 (1.121 : 1.772)

Diarrhoea within 24 hours

4 ( 2.7)

1 ( 0.7)

1.600 (1.017 : 2.518)

Neonatal Death (n, %)

0

3 ( 2.0)

---

If ‘yes, when did the baby die? (n, %)

Before birth

0

1 (33.3)

---

Within 24 hours of birth

0

0

More than 24 hours after birth

0

2 (66.7)

  1. * Anaemia shown by WHO classification: normal (>11 g/dl), mild (9–10.99 g/dl), moderate (7.8.99 g/dl) and severe (<7 g/dl).
  2. ** Misoprostol: admitted with Hb <6 g/dl; placebo: admitted for drainage of breast abscess
  3. *** Drainage of breast abscess
  4. † Respondents could have more than one response. Data missing for 3 in the misoprostol group and 5 in the placebo group.