Incidence of obstetrical thrombotic thrombocytopenic purpura in a retrospective study within thrombocytopenic pregnant women. A difficult diagnosis and a treatable disease

Table 1 Clinical characteristics of four pregnancy-related TTP patients

Patient	Age y.o.	Parity/Term of delivery	Child Sex/weight/ outcome kg-percentile	Smoking	Platelet nadir G/L (Day from delivery)	Clinical data Uricemia (μmol/L)	ADAMTS-13 activity (%) of patient’s Father/Mother (N: 50-150 %)
A	24	P0/28WG	Male	Yes	25	Headache	22/52
			1.3-38p		(D + 2)	Hypertension
			Deceased			Proteinuria
			Deceased			Uricemia 441
B	29	P0/33WG	Male	No	25	Headache	59/34
			2.2-30p		(D0)	No hypertension
			Deceased			No proteinuria
						Uricemia 250
C	22	P0/31WG	Female	Yes	17	Headache	15/43
			1.17-0.1p		(D + 1)	Paresthesia
			Healthy			Hypertension
						Proteinuria
						Uricemia 361
D	35	P3/35WG	Female	Yes	24	Hypertension	Not Done
			2.9-50p		(D + 5)	Proteinuria
			Healthy			Uricemia 194

Patients A, B, C were primipara, whereas, patient D was expecting her fourth child. Patients A and B lost their babies in the neonatal period. For patient A, due to prematurity (enterocolitis at 6 weeks of age) and for patient B, probably because of a coarctation of the aorta and ventricular septal defect (post-partum day 18). All patients except patient B presented features of preeclampsia. Patient D, who presented post-partum auto-immune TTP, had two ADAMTS-13 activity assessments at 22 and 25 months after delivery which showed 11 % and 40 %, respectively, without inhibitor, but was lost to follow-up
(y.o.: years old; WG: weeks of gestation; G/L: Giga per liter; D: day of delivery)

ISSN: 1471-2393