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Table 1 Clinical characteristics of four pregnancy-related TTP patients

From: Incidence of obstetrical thrombotic thrombocytopenic purpura in a retrospective study within thrombocytopenic pregnant women. A difficult diagnosis and a treatable disease

Patient Age y.o. Parity/Term of delivery Child Sex/weight*/ outcome *kg-percentile Smoking Platelet nadir G/L (Day from delivery) Clinical data Uricemia (μmol/L) ADAMTS-13 activity (%) of patient’s Father/Mother (N: 50-150 %)
A 24 P0/28WG Male Yes 25 Headache 22/52
1.3-38p (D + 2) Hypertension
Deceased   Proteinuria
  Uricemia 441
B 29 P0/33WG Male No 25 Headache 59/34
2.2-30p (D0) No hypertension
Deceased   No proteinuria
   Uricemia 250
C 22 P0/31WG Female Yes 17 Headache 15/43
1.17-0.1p (D + 1) Paresthesia
Healthy   Hypertension
  Uricemia 361
D 35 P3/35WG Female Yes 24 Hypertension Not Done
2.9-50p (D + 5) Proteinuria
Healthy   Uricemia 194
  1. Patients A, B, C were primipara, whereas, patient D was expecting her fourth child. Patients A and B lost their babies in the neonatal period. For patient A, due to prematurity (enterocolitis at 6 weeks of age) and for patient B, probably because of a coarctation of the aorta and ventricular septal defect (post-partum day 18). All patients except patient B presented features of preeclampsia. Patient D, who presented post-partum auto-immune TTP, had two ADAMTS-13 activity assessments at 22 and 25 months after delivery which showed 11 % and 40 %, respectively, without inhibitor, but was lost to follow-up
  2. (y.o.: years old; WG: weeks of gestation; G/L: Giga per liter; D: day of delivery)