Outcome/variable % (n) | Type 1 diabetes | Matched control | P-value | Type 2 diabetes | Matched control | P- value | P value T1DM vs T2DM |
---|---|---|---|---|---|---|---|
N = 983 | 215 | 447 |  | 108 | 213 |  |  |
Pre-pregnancy folic acid | 65% | 47% | 0.001 | 55% | 43% | 0.06 | 0.10 |
Maternal outcomes | Â | Â | Â | Â | Â | Â | Â |
Preeclampsia | 12% (12) | 4.3%(19) | .0003 | 8.3% (9) | 8% (17) | 1 | 0.4 |
Gestational hypertension | 20% / 43 | 10% (45) | .0003 | 22% (24) | 11% (23) | .014 | 0.8 |
Emergency section | 29% / 92 | 16% (72) | .0002 | 17% (18) | 15% (32) | .86 | 0.08 |
Elective section | 30% / 65 | 15% (67) | .002 | 36% (39) | 19% (40) | .002 | 0.3 |
Maternal composite* | 46.5% | 25% | .08 | 38% | 29% | .16 | 0.17 |
Neonatal outcomes | Â | Â | Â | Â | Â | Â | Â |
Miscarriage | 11% | N/A** | Â | 8.3% | N/A** | Â | 0.5 |
Stillbirth | 2.8%(6) | 0.4% (2) | .027 | 1.9% (2) | 0.9%(2) | .86 | 0.5 |
Neonatal deaths | 0 | 0 | Â | 0 | 0 | ||
Live birth rate | 85.6% | 99% | .0001 | 90% | 97.7% | .012 | 0.25 |
Congenital malformation | 4.2% (9) | 1.6% (7) | .074 | 2.8% (3) | 1.9% (4) | .90 | 0.74 |
Polyhydramnios | 10% (22) | 1.8% (8) | .001 | 6.5% (7) | 5.6%(12) | .95 | 0.36 |
Neonatal hypoglycemia | 20% (43) | 0.4% (2) | .0001 | 6.5% (7) | 0.5% (1) | 0.004 | 0.002 |
Hypocalcemia | 0 | 0.2% (1) | 1 | 0 | 0 | 1 | |
Neonatal jaundice | 6% (13) | 5.4%(24) | 0.86 | 8.3% (9) | 4.7%(10) | 0.29 | |
Shoulder dystocia | 2.3% (5) | 1.1% (5) | 0.39 | 1% (1) | 0.5% (2) | 1 | |
Polycythemia | 0.9% (2) | 0% | 0.19 | 0.9% (1) | 0 | 0.72 | |
Mean (kg) | 3.54 ± 0.6 | 3.54 ± 0.6 | 1 | 3.52 ± 0.8 | 3.54 ± 0.7 | 1 | 1 |
Weight >4Â kg (%) | 30% | 21% | 0.03 | 20% | 24% | 0.4 | 0.08 |
Weight >4.5Â kg | 6.5% | 4% | 0.27 | 8.2% | 3.8% | 0.16 | 0.76 |
Large for gestational age | 24% | 17% | 0.07 | 20% | 22% | 0.9 | 1 |
Small for gestational age | 5.6% | 6.5% | 0.8 | 5.6% | 6.5% | 0.9 | 1 |
Delivery < 37 weeks | 28% (60) | 5.4%(24) | .001 | 22% (24) | 8.5%(18) | .001 | 0.29 |
Neonatal Unit care | 55% | 14%% | .0001 | 39% | 17% (36) | .0001 | 0.009 |
Antepartum hemorrhage | 0.9% (2) | 3% (13) | 0.14 | 0% | 3% (6) | 0.13 | 0.8 |
Postpartum hemorrhage | 2.8% (6) | 4.9%(22) | 0.28 | 3.7% (4) | 4.7%(10) | 0.9 | 0.9 |
Neonatal composite*** | 48% | 6.5% | .0001 | 32% | 10% | .06 | 0.008 |