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Table 4 Characteristics of published studies of the association between the eNOS genotype (Glu298Asp) and pre-eclampsia included in the meta-analysis

From: Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis

Study-year (Country) Study design Matching Asp/Asp * genotype (%) Primiparous (%) Cases Controls Proteinuria threshold Systolic/Diastolic blood pressure threshold Main exclusion criteria
Caucasians
Hakli T-2003 (Finland) Case-control Age 10.61 100 -- 0.3 g/24 h 140/90 • Hypertension
Tempfer CB-2004‡ (Austria) Case-control Gestational age and parity -- -- -- 5 g/24 h 160/110 • Cardiac (Hypertension), diabetes mellitus or renal disease
• Multiple pregnancies
• Autoimmune disorders & history of recurrent miscarriage
Oriental
Yoshimura T-2000 (Japan) Case-control Age 1.17 68.7 80 0.3 g/L 140/90 • Cardiac, diabetes mellitus or renal disease
• Lupus erythematosus
• Multiple pregnancies
Kobashi G-2001 (Japan) Case-control -- 0 59.2 57 0.3 g/L 140/90 • Hypertension, diabetes mellitus or renal disease
• Multiple pregnancies
• Amniotic volume abnormalities or fetal anomalies
Watanabe H-2001‡ (Japan) Case-control -- 3.12 -- -- 2 g/24h 160/110 • Hypertension
• Renal disease
Ohta K-2004‡ (Japan) Case-control -- 0 100 100 2 g/24 h 160/110 • Hypertension, diabetes mellitus, renal disease
• Multiple pregnancies
• Amniotic volume abnormalities or fetal anomalies
Kim YJ (Korea) Case-control -- -- 21 31 0.3 g/L 140/90 • Hypertension, diabetes mellitus or renal disease
• Multiple pregnancies, recurrent miscarriages, fetal growth retardation or abruption placenta
Asians
Yoshimura T-2003‡ (Bangladesh) Case-control Age 3.36 44.6 51.2 ≥ 3+ dipstick 160/110 • Hypertension, Diabetes mellitus or renal disease
• Lupus erythematosus
• Multiple pregnancies
Afro-Caribbeans
Hillermann R‡ (South Africa) Case-control -- 1.19 100 -- 0.3 g/L --/90 • Hypertension, diabetes mellitus, renal disease
Study-year (Country) Study design Matching Asp/Asp * genotype (%) Primiparous (%) Cases Controls Proteinuria threshold Systolic/Diastolic blood pressure threshold Main exclusion criteria
Mixed population
Landau R-2004 (United States) Case-control -- 5.03 55 41 0.3 g/L 140/90 • Hypertension
Yu C. KH-2004 (United Kingdom) Case-control -- 7.44 56.3 69.3 0.3 g/24 h 140/90 • Cardiac, diabetes mellitus or renal disease
• Lupus erythematosus
• Multiple pregnancies
Serrano NC-2004 (Colombia) Case-control -- 1.14 100 100 0.3 g/24 h 140/90 • Cardiac (Hypertension), diabetes mellitus or renal disease
• Multiple pregnancies
• Lupus erythematosus
  1. *; Genotype frequency from control subjects. ‡ Studies in which only women with severe pre-eclampsia were included as cases.
  2. †; Landau R included Hispanic and White American women, Yu C.KH included Caucasian, Afro-Caribbean, and Asian women and Serrano N included Hispanic and Afro-Caribbean women.