Table 4 Characteristics of published studies of the association between the eNOS genotype (Glu298Asp) and pre-eclampsia included in the meta-analysis
Study-year (Country) | Study design | Matching | Asp/Asp * genotype (%) | Primiparous (%) Cases Controls | Proteinuria threshold | Systolic/Diastolic blood pressure threshold | Main exclusion criteria | |
|---|---|---|---|---|---|---|---|---|
Caucasians | ||||||||
Hakli T-2003 (Finland) | Case-control | Age | 10.61 | 100 | -- | 0.3 g/24 h | 140/90 | • Hypertension |
Tempfer CB-2004‡ (Austria) | Case-control | Gestational age and parity | -- | -- | -- | 5 g/24 h | 160/110 | • Cardiac (Hypertension), diabetes mellitus or renal disease • Multiple pregnancies • Autoimmune disorders & history of recurrent miscarriage |
Oriental | ||||||||
Yoshimura T-2000 (Japan) | Case-control | Age | 1.17 | 68.7 | 80 | 0.3 g/L | 140/90 | • Cardiac, diabetes mellitus or renal disease • Lupus erythematosus • Multiple pregnancies |
Kobashi G-2001 (Japan) | Case-control | -- | 0 | 59.2 | 57 | 0.3 g/L | 140/90 | • Hypertension, diabetes mellitus or renal disease • Multiple pregnancies • Amniotic volume abnormalities or fetal anomalies |
Watanabe H-2001‡ (Japan) | Case-control | -- | 3.12 | -- | -- | 2 g/24h | 160/110 | • Hypertension • Renal disease |
Ohta K-2004‡ (Japan) | Case-control | -- | 0 | 100 | 100 | 2 g/24 h | 160/110 | • Hypertension, diabetes mellitus, renal disease • Multiple pregnancies • Amniotic volume abnormalities or fetal anomalies |
Kim YJ (Korea) | Case-control | -- | -- | 21 | 31 | 0.3 g/L | 140/90 | • Hypertension, diabetes mellitus or renal disease • Multiple pregnancies, recurrent miscarriages, fetal growth retardation or abruption placenta |
Asians | ||||||||
Yoshimura T-2003‡ (Bangladesh) | Case-control | Age | 3.36 | 44.6 | 51.2 | ≥ 3+ dipstick | 160/110 | • Hypertension, Diabetes mellitus or renal disease • Lupus erythematosus • Multiple pregnancies |
Afro-Caribbeans | ||||||||
Hillermann R‡ (South Africa) | Case-control | -- | 1.19 | 100 | -- | 0.3 g/L | --/90 | • Hypertension, diabetes mellitus, renal disease |
Study-year (Country) | Study design | Matching | Asp/Asp * genotype (%) | Primiparous (%) Cases Controls | Proteinuria threshold | Systolic/Diastolic blood pressure threshold | Main exclusion criteria | |
Mixed population †| ||||||||
Landau R-2004 (United States) | Case-control | -- | 5.03 | 55 | 41 | 0.3 g/L | 140/90 | • Hypertension |
Yu C. KH-2004 (United Kingdom) | Case-control | -- | 7.44 | 56.3 | 69.3 | 0.3 g/24 h | 140/90 | • Cardiac, diabetes mellitus or renal disease • Lupus erythematosus • Multiple pregnancies |
Serrano NC-2004 (Colombia) | Case-control | -- | 1.14 | 100 | 100 | 0.3 g/24 h | 140/90 | • Cardiac (Hypertension), diabetes mellitus or renal disease • Multiple pregnancies • Lupus erythematosus |