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Table 3 Laboratory data (geometric mean and 95% confidence interval) for young women participants (age 19–44 years) in Phase I and Phase II

From: A comprehensive evaluation of food fortification with folic acid for the primary prevention of neural tube defects

Characteristic Phase I Phase II p value
Total participants (n) 233 204  
   Serum folate (nmol/L) 13.5 (12.9 – 14.1) 18.1 (17.3 – 18.9) <0.001
   RBC folate (mol/L) 625 (601 – 649) 818 (784 – 854) <0.001
   Plasma HCY (μmol/L) 10.2 (9.8 – 10.7) 9.2 (8.8 – 9.6) 0.001
   Serum vitamin B12 (pmol/L) 177 (169 – 186) 200 (190 – 211) 0.02
   Plasma MMA (μmol/L) 0.18 (0.17 – 0.19) 0.21 (0.19 – 0.22) 0.008
  1. † P value for the difference between Phase I and Phase II is based on a non-parametric Mann-Whitney U test.
  2. RBC denotes red blood cell, HCY denotes homocysteine, and MMA refers to methylmalonic acid.