Table 2 Indicators of chorioamnionitis: clinical, histologic and microbiological
From: Cerebral palsy and placental infection: a case-cohort study
| Â | Cases | Sub-Cohort | Relative risk (95% Confidence Intervals) | P value |
|---|---|---|---|---|
Clinical indicators | n = 82 | n = 207 | Â | Â |
Recorded clinical chorioamnionitis | 10 (12%) | 27 (13%) | 0.94 [0.54, 1.64] | 0.84 |
   Maternal fever a | 21 (26%) | 40 (19%) | 1.26 [0.84, 1.87] | 0.26 |
   Uterine tenderness | 13 (16%) | 30 (14%) | 1.13 [0.69, 1.82] | 0.63 |
   Maternal tachycardia | 15 (18%) | 49 (24%) | 0.78 [0.48, 1.26] | 0.31 |
   Fetal tachycardia | 11 (13%) | 33 (16%) | 0.87 [0.51, 1.49] | 0.62 |
Elevated maternal C-reactive protein (>6 mg/L) /no. tested | 29 /38 (76%) | 49 /78 (63%) | 1.75 [0.93, 3.30] | 0.08 |
Abnormal maternal whiteblood count >15,000 × 10 6 /L/no. tested | 55 /70 (79%) | 114 /159 (72%) | 1.37 [0.85, 2.23] | 0.20 |
Neonatal sepsis | 18 (22%) | 30 (14%) | 1.45 [0.97, 2.18] | 0.07 |
Placental Microbiology | n = 30 | n = 85 | Â | Â |
One or more isolates | 11(37%) | 30 (35%) | 1.05 [0.56, 1.96] | 0.88 |
   Group B Streptococcus | 4 (13%) | 5 (6%) | 1.85 [0.86, 3.97] | 0.12 |
   Escherichia coli | 6 (20%) | 4 (5%) | 2.35 [1.27, 4.34] | 0.01 |
   Bacteroides/Prevotella spp. | 3 (10%) | 5 (6%) | 1.54 [0.62, 3.84] | 0.35 |
   Ureaplasma spp. | 3 (10%) | 14 (16%) | 0.66 [0.23, 1.90] | 0.44 |
   Other isolates | 4 (13%) | 15 (18%) | 0.79 [0.32, 1.97] | 0.61 |
Placental histopathology | Â | Â | Â | Â |
   Chorioamnionitis | n = 54 | n = 150 |  |  |
| Â | 22 (41%) | 56 (37%) | 1.19 [0.76, 1.88) | 0.45 |
   Funisitis | n = 54 | n = 144 |  |  |
| Â | 14 (26%) | 31 (22%) | 1.35 [0.83, 2.21] | 0.23 |