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Table 4 ROC curve analyses for combinations of markers and the DR for preeclampsia at a fixed FPR of 10% and 5% using a logistic regression model

From: Screening models using multiple markers for early detection of late-onset preeclampsia in low-risk pregnancy

Variable Cutoff1 DR1 Cutoff2 DR2 Area S E p-value 95% CI Variable
PAPP-A + Inhibin A 5.01% 50 9.19% 37.5 0.812 0.093 0.003 0.629 0.995
PAPP-A + sFlt-1/PlGF1 2.85% 87.5 4.72% 87.5 0.969 0.015 <0.001 0.940 0.999
PAPP-A + sFlt-1/PlGF2 2.62% 62.5 4.07% 50 0.917 0.036 <0.001 0.847 0.988
BMI + sFlt-11 4.6% 87.5 8.9% 75 0.937 0.039 <0.001 0.861 1.000
sFlt-1/PlGF1 + sFlt-1/PlGF2 2.2% 87.5 3.4% 87.5 0,946 0.043 <0.001 0.862 1.000
  1. The exploratory variable in each case is the risk determined by the logistic equation.
  2. Cutoff1: cutoff value at a fixed FPR of 10%, DR1: DR at a fixed FPR of 10%, Cutoff2: cutoff value at a fixed FPR of 5%, DR2: DR at a fixed FPR of 5%, PAPP-A: pregnancy-associated plasma protein-A, sFlt-11: second trimester sFlt-1, sFlt-1/PlGF1: second trimester sFlt-1/PlGF ratio, sFlt-1/PlGF2: third trimester sFlt-1/PlGF ratio, SE: standard error.