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Table 3 Infant adipose tissue growth assessed by skinfold thickness measurements and ultrasonography from week-1 to year-1

From: Effect of maternal obesity with and without gestational diabetes on offspring subcutaneous and preperitoneal adipose tissue development from birth up to year-1

 

Lean group

Obese group

Obese GDM group

P-value1

Adjusted p-value2

SFT [mm]

     

  Week-1

18.9 ± 3.1 [15]

20.3 ± 2.6 [13]

21.6 ± 2.4 [16]

0.031a

0.031a

  Week-6

25.2 ± 3.7 [15]

26.1 ± 5.1 [13]

30.4 ± 3.4 [12]

0.007a,b

0.048a

  Month-4

30.7 ± 6.6 [15]

31.2 ± 4.3 [11]

33.6 ± 4.8 [13]

0.336

0.258

  Year-1

29.0 ± 4.3 [15]

30.3 ± 4.6 [12]

29.7 ± 4.8 [14]

0.749

0.536

Fat mass [g] 3

     

  Week-1

583 ± 139 [15]

660 ± 114 [13]

694 ± 117 [16]

0.051

0.042a

  Week-6

1,008 ± 159 [15]

1,098 ± 285 [13]

1,307 ± 187 [12]

0.004a,b

0.048a

  Month-4

1,581 ± 318 [15]

1,728 ± 327 [11]

1,847 ± 328 [13]

0.108

0.184

  Year-1

2,260 ± 419 [15]

2,475 ± 536 [12]

2,444 ± 530 [14]

0.466

0.498

Trunk-total SFT ratio (%) 4

     

  Week-1

47.4 ± 2.5 [15]

47.2 ± 3.3 [13]

48.1 ± 2.9 [16]

0.630

0.958

  Week-6

48.4 ± 3.2 [15]

49.4 ± 3.4 [13]

49.1 ± 2.4 [12]

0.648

0.528

  Month-4

49.0 ± 4.1 [15]

48.9 ± 2.4 [11]

49.6 ± 3.1 [13]

0.841

0.647

  Year-1

45.1 ± 2.6 [15]

44.9 ± 2.6 [12]

48.5 ± 3.3 [14]

0.002a,b

0.035a,b

SCA (mm 2 ) 5

     

  Week-1

12.7 (9.5-15.4) [12]

16.7 (14.0-19.9) [12]

17.7 (16.8-19.4) [12]

0.020a

0.014a

  Week-6

24.0 ± 6.6 [15]

26.5 ± 10.7 [13]

34.6 ± 7.9 [12]

0.008a,b

0.058a

  Month-4

41.3 ± 12.8 [15]

42.9 ± 9.4 [11]

45.6 ± 12.7 [13]

0.644

0.458

  Year-1

24.6 (18.6-27.7) [15]

29.0 (26.8-36.2) [12]

34.2 (22.8-43.6) [14]

0.132

0.217

PPA (mm 2 ) 5

     

  Week-1

5.6 (4.9-7.9) [12]

7.9 (6.3-9.3) [12]

10.0 (8.9-12.2) [12]

0.001a

0.001a,b

  Week-6

10.0 ± 2.7 [15]

11.4 ± 3.6 [13]

13.9 ± 2.9 [12]

0.009a

0.183

  Month-4

13.5 (9.7-14.1) [15]

16.9 (12.1-18.6) [11]

15.6 (11.5-18.0) [13]

0.221

0.525

  Year-1

17.5 ± 4.9 [15]

22.3 ± 7.0 [12]

20.8 ± 6.7 [14]

0.130

0.368

  1. PPA: preperitoneal adipose tissue; SCA: subcutaneous adipose tissue; SFT: sum of the 4 skinfold thickness measurements (biceps + triceps + subscapular + suprailiac).
  2. Data are presented as mean ± SD; otherwise skewed variables are presented as median followed by interquartile range; numbers in brackets represent number of infants included in the analysis.
  3. 1One-way ANOVA with Sidak’s post hoc test or nonparametric Kruskal-Wallis-test with Dunn’s post hoc test.
  4. 2Statistical analyses were performed by multiple linear regression models. P-values for parameters at week-1 were adjusted for infant sex, pregnancy duration and age at investigation. P-values at week-6, month-4 and year-1 were adjusted for infant sex, pregnancy duration, age at investigation and corresponding breastfeeding status.
  5. aP-value < 0.05 obese GDM vs. lean group; bp-value < 0.05 obese GDM vs. obese group.
  6. 3Fat mass was estimated from the sum of 4 SFTs by using the equations of Weststrate and Deurenberg [22].
  7. 4Trunk-total SFT ratio (%) was evaluated by applying the equation (subscapular + suprailiac SFT)/(sum of 4 SFTs) × 100 of Westrate et al. [23].
  8. 5SCA and PPA were measured as areas of 1-cm length according to the method of Holzhauer et al. [18]. SCA indicates mean area from axial + sagittal plane.