Skip to main content

Table 2 Medical and obstetric data

From: False positive morphologic diagnoses at the anomaly scan: marginal or real problem, a population-based cohort study

  Total cohort False positives Misclassification True positive P6
  (n = 526) (n = 39) (n = 49) (n = 438)  
  % [m ± SD] % [m ± SD] % [m ± SD] % [m ± SD]  
Number of pregnancies 1 (n = 526) (n = 39) (n = 49) (n = 438)  
[1.3 ± 1.5] [1.1 ± 1.3] [1.7 ± 1.8] [1.3 ± 1.5] 0.38
Miscarriages (n = 518) (n = 39) (n = 49) (n = 430)  
9.6 17.1 34.7 18.1 0.02
Elective termination (n = 519) (n = 39) (n = 49) (n = 431)  
12.9 6.4 16.3 13.2 0.31
TOPFA 2 (n = 517) (n = 39) (n = 49) (n = 429)  
1.7 4.3 2.0 1.4 0.16
Nulliparous (n = 524) (n = 39) (n = 49) (n = 436)  
48.1 46.8 44.9 48.6 0.44
Maternal diseases 3 (n = 520) (n = 39) (n = 49) (n = 432)  
 Diabetes 5.3 6.4 4.1 6.3 0.87
 Epilepsy 0.9 0 0 1.2 0.37
 Hypertension 0.8 2.1 0 0.7 0.35
Familial malformations (n = 525) (n = 39) (n = 49) (n = 437)  
 Similar malformation 6.9 0 6.1 7.8 0.11
 Different malformation 14.6 8.5 10.2 15.8 0.27
Multiple pregnancy (n = 526) (n = 39) (n = 49) (n = 438)  
  3.4 0 8.2 3.2 0.08
ART 4 (n = 520) (n = 38) (n = 46) (n = 436)  
  6.1 2.2 8.7 6.2 0.68
PRD 5 (n = 508) (n = 38) (n = 47) (n = 423) 0.64
  33.1 28.3 29.3 34.0 0.64
Amniotic fluid anomaly (n = 516) (n = 39) (n = 49) (n = 428)  
 Oligoamnios 7.7 0 18.4 7.5 0.01
 Hydramnios 6.6 2.1 8.2 6.8  
  1. 1Number of pregnancies, mean. 2 TOPFA (Termination Of Pregnancy for Fetal Anomaly):In France, when a termination of pregnancy is envisaged for the reason that there is a strong probability that the child has a particularly severe condition recognized as incurable at the time of diagnosis, a multidisciplinary team from the authorised antenatal diagnostic center is responsible for examining the woman’s request and issuing an advisory opinion. If at the conclusion of this team’s assessment, two physicians consider that there is a strong probability that the child has such a condition, they complete a written attestation, one copy of which is provided to the woman. 3Maternal chronic disease (preceding the pregnancy) 4ART (Assisted Reproductive Technologies) 5PRD (Pregnancy related diseases including pregnancy related diabetes or hypertension, preeclampsia, etc.) 6Comparison of 3 groups: False positives, misclassifications, True positives.