False positive morphologic diagnoses at the anomaly scan: marginal or real problem, a population-based cohort study

Table 2 Medical and obstetric data

	Total cohort	False positives	Misclassification	True positive	P⁶
	(n = 526)	(n = 39)	(n = 49)	(n = 438)
	% [m ± SD]	% [m ± SD]	% [m ± SD]	% [m ± SD]
Number of pregnancies ¹	(n = 526)	(n = 39)	(n = 49)	(n = 438)
Number of pregnancies ¹	[1.3 ± 1.5]	[1.1 ± 1.3]	[1.7 ± 1.8]	[1.3 ± 1.5]	0.38
Miscarriages	(n = 518)	(n = 39)	(n = 49)	(n = 430)
Miscarriages	9.6	17.1	34.7	18.1	0.02
Elective termination	(n = 519)	(n = 39)	(n = 49)	(n = 431)
Elective termination	12.9	6.4	16.3	13.2	0.31
TOPFA ²	(n = 517)	(n = 39)	(n = 49)	(n = 429)
TOPFA ²	1.7	4.3	2.0	1.4	0.16
Nulliparous	(n = 524)	(n = 39)	(n = 49)	(n = 436)
Nulliparous	48.1	46.8	44.9	48.6	0.44
Maternal diseases ³	(n = 520)	(n = 39)	(n = 49)	(n = 432)
Diabetes	5.3	6.4	4.1	6.3	0.87
Epilepsy	0.9	0	0	1.2	0.37
Hypertension	0.8	2.1	0	0.7	0.35
Familial malformations	(n = 525)	(n = 39)	(n = 49)	(n = 437)
Similar malformation	6.9	0	6.1	7.8	0.11
Different malformation	14.6	8.5	10.2	15.8	0.27
Multiple pregnancy	(n = 526)	(n = 39)	(n = 49)	(n = 438)
	3.4	0	8.2	3.2	0.08
ART ⁴	(n = 520)	(n = 38)	(n = 46)	(n = 436)
	6.1	2.2	8.7	6.2	0.68
PRD ⁵	(n = 508)	(n = 38)	(n = 47)	(n = 423)	0.64
	33.1	28.3	29.3	34.0	0.64
Amniotic fluid anomaly	(n = 516)	(n = 39)	(n = 49)	(n = 428)
Oligoamnios	7.7	0	18.4	7.5	0.01
Hydramnios	6.6	2.1	8.2	6.8

¹Number of pregnancies, mean. ² TOPFA (Termination Of Pregnancy for Fetal Anomaly):In France, when a termination of pregnancy is envisaged for the reason that there is a strong probability that the child has a particularly severe condition recognized as incurable at the time of diagnosis, a multidisciplinary team from the authorised antenatal diagnostic center is responsible for examining the woman’s request and issuing an advisory opinion. If at the conclusion of this team’s assessment, two physicians consider that there is a strong probability that the child has such a condition, they complete a written attestation, one copy of which is provided to the woman. ³Maternal chronic disease (preceding the pregnancy) ⁴ART (Assisted Reproductive Technologies) ⁵PRD (Pregnancy related diseases including pregnancy related diabetes or hypertension, preeclampsia, etc.) ⁶Comparison of 3 groups: False positives, misclassifications, True positives.

ISSN: 1471-2393