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Table 1 Characteristics and methods of studies included in review (by date).

From: Key components of early intervention programs for preterm infants and their parents: a systematic review and meta-analysis

Study Study quality* Infants enrolled Drop outs No. of sites Mean GA (weeks) Mean birth weight (grams) Group allocation Follow-up
   n n (%)   I C I C I (n) C (n)  
IHDP
1990
4 985 72(7.3) 8 33.0 33.0 1819 1781 377 608 18 yrs
Kang
1995
2 327 82(25.1) 3 33.1g 33.1g 1938g 1938g 197 130 5 m
Saylor
1996
3 68 3(4.4) 1 28.9 30.3 1107 1231 34f 31f* 7 yrs
APIP
1998
4 328 42(12.8) 2 31.0 d P
30.0d PA
31.0d 1560 P
1331 PA
1420 116 P
106 PA
106 5 yrs
Melynk
2001
2 55 13(23.6) 1 31.4 31.6 1483 1731 26 29 6 m
Brisch
2003
2 87 11(12.6) 1 27.0 27.0 919 987 43 44 24 m
Ohgi
2004
3 23 1(4.2) 1 30.3 30.3 1273 1360 12 11 6 m
Gianni
2006
2 36 0(0) 1 28.3 27.5 892 836 18 18 36 m
Kaaresen
2006
4 146
75a
7(3.2) 1 30.2 29.9 1402 1393 72 74
75b
5 yrs
Melynk
2006
3 260 13(5.8) 2 31.3 31.4 1683 1627 147 113 2 m
Glazebrook
2007b
3 233 11(4.7) 6 28.5d 29.0d 1121 1220 112 121 24 m
Koldewijn
2009
3 176 1(0.6) 7 29.6 30.0 1242 1306 86 90 7 yrs
Newnham
2009
3 68 5(7.4) 1 31.3 33.7 1590 1619 35 33 24 m
Teti
2009
3 194 21(10.8) 4 30.6 30.0 1455 1397 99 95 4 m
Milgrom
2010
4 45 0(0) 1 27.5 27.7 981 999 22 23 0
Neu
2010
2 87 8(9.2) 5 33.1 33.4e
33.4e
1990 1880
1980
31 29e
27e*
4 m
Spittle
2010
4 120 3(2.5) 2 27.3 27.4 1029 991 61 59 24 m
Ravn
2011
4 118 0(0) 1 33.3 33.2 1935 1919 61 57 12 m
  1. Note: *Study methodological quality was assessed by Cochrane Collaboration’s Tool [44].
  2. GA = gestational age; I = Intervention group; C = Control or comparison group; m = months; yrs = years
  3. Programs: APIP = Avon Premature Infant Project; IHDP = Infant Health Development Program; P = Portage intervention; PA, = Parent Advisor intervention
  4. a Matched term controls
  5. b Cluster RCT with washout and crossover
  6. c Case matched by developmental risk score, then randomly allocated to groups
  7. d Median
  8. e Holding comparison group; e* Control group
  9. f Early intervention group; f* Late intervention group
  10. g Overall mean for cohort