|
White Subgroup
|
|---|
|
Gene/tSNP
|
Genotype Groups
|
OR
|
99% CI
|
p-valuea
|
|---|
|
ENG: rs10121110
|
AA vs. GG
|
2.29
|
1.02 - 5.13
|
0.008
|
|
AG vs. GG
|
1.52
|
0.69 - 3.36
|
0.17
|
|
TGFBR2: rs6550005b
|
GG vs. AA + GA
|
1.60
|
0.89 - 2.87
|
0.04
|
|
Black Subgroup
|
|
Gene/tSNP
|
Genotype Groups
|
OR
|
99% CI
|
p-value
|
|
TGFβ1: rs4803455
|
AA vs. CC
|
0.39
|
0.06 - 2.61
|
0.20
|
|
CA vs. CC
|
3.04
|
0.56 - 16.33
|
0.09
|
|
TGFβ1:rs4803457
|
TT vs. CC
|
3.50
|
0.50 - 24.53
|
0.10
|
|
CT vs. CC
|
7.44
|
1.19 - 46.41
|
0.005
|
|
TGFβR1: rs10739778
|
CC vs. AA
|
0.19
|
0.02 - 2.08
|
0.07
|
|
AC vs. AA
|
0.24
|
0.05 - 1.09
|
0.02
|
- Abbreviations: tSNP, tagging single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
-
a α set at 0.01 because of multiple testing.
-
b SNP genotypes dichotomized (homozygote wildtype, homozygote variant + heterozygote) due to small homozygote variant frequencies in either cases, controls, or both.
