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Table 4 Logistic regression for tSNPs with significant genotype tests

From: Variation in endoglin pathway genes is associated with preeclampsia: a case–control candidate gene association study

White Subgroup

Gene/tSNP

Genotype Groups

OR

99% CI

p-valuea

ENG: rs10121110

AA vs. GG

2.29

1.02 - 5.13

0.008

AG vs. GG

1.52

0.69 - 3.36

0.17

TGFBR2: rs6550005b

GG vs. AA + GA

1.60

0.89 - 2.87

0.04

Black Subgroup

Gene/tSNP

Genotype Groups

OR

99% CI

p-value

TGFβ1: rs4803455

AA vs. CC

0.39

0.06 - 2.61

0.20

CA vs. CC

3.04

0.56 - 16.33

0.09

TGFβ1:rs4803457

TT vs. CC

3.50

0.50 - 24.53

0.10

CT vs. CC

7.44

1.19 - 46.41

0.005

TGFβR1: rs10739778

CC vs. AA

0.19

0.02 - 2.08

0.07

AC vs. AA

0.24

0.05 - 1.09

0.02

  1. Abbreviations: tSNP, tagging single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
  2. a α set at 0.01 because of multiple testing.
  3. b SNP genotypes dichotomized (homozygote wildtype, homozygote variant + heterozygote) due to small homozygote variant frequencies in either cases, controls, or both.
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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