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Table 2 The prevalence of antibodies against gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and their receptors

From: Autoantibodies and gastrointestinal symptoms in infertile women in relation to in vitro fertilization

  Patients before IVF Patients after IVF Blood donors BD vs. before IVF Before vs. after IVF
  N = 96 N = 96 N = 169 P-value P-value
GnRH IgM, n (%) 5 (5.2) 3 (3.1) 4 (2.4) 0.292 0.721
GnRH-R IgM, n (%) 13 (13.5) 10 (10.4) 4 (2.4) 0.001 0.657
LH IgM, n (%) 5 (5.3) 2 (2.1) 5 (3.0) 0.504 0.444
LH IgG, n (%) 14 (14.6) 5 (5.3) 5 (3.0) 0.001 0.051
LH-R IgM, n (%) 6 (6.3) 6 (6.3) 6 (3.6) 0.362 1.000
LH-R IgG, n (%) 9 (9.4) 9 (9.4) 4 (2.4) 0.016 1.000
  1. BD = Blood donors, IVF = in vitro fertilization, n (%) = number of patients. Antibody levels above the cut-off of relative units >97.5th percentile in a cohort of 169 healthy female blood donors were considered as presence of antibodies. No IgG antibodies against GnRH or its receptor were found in patients. Fisher’s exact test (2-sided). P < 0.05 was considered statistically significant.