Misoprostol | Surgical | p-value | |
---|---|---|---|
n = 465 | n = 374 | ||
Severity of side effects | |||
“None” | 14.8 (65/440) | 24.0 (53/221) | 0.02 |
“Easily tolerable” / “tolerable” | 77.5 (341/440) | 71.0 (157/221) | |
“Severe” / “very severe” | 7.7 (34/440) | 5.0 (11/221) | |
Normal bleeding** | 35.4 (119/336) | 9.4 (17/180) | < 0.001 |
Heavy bleeding** | 11.6 (39/336) | 0.6 (1/180) | < 0.001 |
Spotting*** | 31.0 (104/336) | 51.1 (92/180) | < 0.001 |
Pain/cramps** | 54.8 (184/336) | 24.4 (44/180) | < 0.001 |
Fever/chills** | 3.9 (13/336) | 1.7 (3/180) | 0.20 |
Nausea** | 16.7 (56/336) | 2.8 (5/180) | < 0.001 |
Vomiting** | 7.1 (24/336) | 1.1 (2/180) | < 0.01 |
Headache† | 7.7 (26/336) | 8.9 (16/180) | 0.74 |
Gastrointestinal issues† | 15.2 (51/336) | 3.9 (7/180) | < 0.001 |
Vertigo† | 1.2 (4/336) | 4.4 (8/180) | 0.03 |
Tolerability of pain** | |||
“No pain” | 5.1 (17/332) | 5.6 (10/177) | < 0.01 |
“Very tolerable” / “tolerable” | 92.2 (306/332) | 85.3 (151/177) | |
“Not tolerable” | 2.7 (9/332) | 9.0 (16/177) | |
Difficulty of treatment*** | 0.45 | ||
“Not at all difficult” / “a little difficult” | 95.4 (290/304) | 97.4 (148/152) | |
“Difficult” / “very difficult” | 4.6 (14/304) | 2.6 (4/152) | |
Acceptability of bleeding** | |||
“Acceptable” / “very acceptable” | 99.1 (328/331) | 100.0 (174/174) | 0.56 |
“Not acceptable” | 0.9 (3/331) | 0.0 (0/0) |