GRADE symbol | Level of confidence in quality of evidence | Definition | Criteria |
---|---|---|---|
⊕ ⊕ ⊕ ⊕ | High | We are confident the true effect lies close to the estimate of the effect. | One or more studies were appraised at low risk of bias. |
⊕ ⊕ ⊕ | Moderate | We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. | No studies were appraised at low risk of bias, although one or more studies were appraised at moderate risk of bias. |
⊕ ⊕ | Low | Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. | No studies were appraised as low or moderate risk of bias. One or more studies were appraised at high risk of bias. |
⊕ | Very low | We have very little confidence in the effect estimate. | The publications were not in a format that allowed appraisal of the effect estimate (e.g. opinion piece). |