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Table 4 Classification of quality of evidence base for screening for gestational diabetes mellitus in indigenous women

From: Diabetes in pregnancy among indigenous women in Australia, Canada, New Zealand, and the United States: a method for systematic review of studies with different designs

GRADE symbol Level of confidence in quality of evidence Definition Criteria
High We are confident the true effect lies close to the estimate of the effect. One or more studies were appraised at low risk of bias.
Moderate We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. No studies were appraised at low risk of bias, although one or more studies were appraised at moderate risk of bias.
Low Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. No studies were appraised as low or moderate risk of bias. One or more studies were appraised at high risk of bias.
Very low We have very little confidence in the effect estimate. The publications were not in a format that allowed appraisal of the effect estimate (e.g. opinion piece).