Growth factor concentrations and their placental mRNA expression are modulated in gestational diabetes mellitus: possible interactions with macrosomia

Table 3 Independent variables included in the forward linear stepwise multiple regression model for the birth weight (BW)

VARIABLE	INITIAL MODEL				FINAL MODEL
		95% confidence interval				95% confidence interval
	Mean difference in birth weight (g)	Lower bound	Upper bound	P	Mean difference in birth weight (g)	Lower bound	Upper bound	P
Constant	- 1563	- 7199	4073	0.287	- 1264	- 3124	596	0.170
PDGF-NB	0.659	-3	5	0.594	-	-	-	-
PDGF-M	5.023	2	8	0.002	5.041	3	7	0
IGF-BP3-NB	-0.571	- 2	0	0.177	-	-	-	-
IGF-BP3-M	0.058	0	0	0.277	-	-	-	-
FGF-2-NB	-	-	-	0.074	7.673	5	10	0
FGF-2-M	3.321	- 1	8	0.029	2.743	0	6	0.057
GH-NB	25.320	- 24	75	0.161	-	-	-	-
GH-M	602	- 742	1945	0.100	-	-	-	-
EGF-NB	6.228	1	11	0.001	-	-	-	-
IGF-1-NB	-5.690	-3	2	0.781	-	-	-	-
IGF-1-M	0.466	- 1	2	0.619	-	-	-	-
Gender	366	-56	788	0.082	-	-	-	-

PDGF-NB: Platelet derived growth factor-New born, PDGF-M: Platelet derived growth factor-Mother, IGF-BP3-NB: Insulin-like growth factor binding protein-3 New born, IGF-BP3 M:Insulin-like growth factor binding protein-3 Mother, FGF-2 NB: Fibroblast growth factor-2 New born, FGF-2 M: Fibroblast growth factor-2 Mother, GH-NB: Growth hormone-New born, GH M: Growth hormone- Mother, EGF-NB: Epidermal growth factor-New born, IGF-1 NB: Insulin-like growth factor-I New born, IGF-1 M: Insulin-like growth factor-I-Mother, infant's gender (male/female). Proposed model for the total sample: BW (g) = 5.041 × PDGF-M + 2.743 × FGF2-M + 7.673 × FGF2-NB-1264. GH should be considered as pituitary-GH.

ISSN: 1471-2393