Skip to main content

Advertisement

Biomedical aspects of pregnancy

This section considers studies regarding biomedical and therapeutic aspects of pregnancy.

Page 2 of 3

  1. Streptococcus agalactiae or Group B Streptococcus (GBS) remains the leading cause of infections in newborns worldwilde. Prenatal GBS screening of pregnant women for vaginal-rectal colonization is recommended in m...

    Authors: Eliane Saori Otaguiri, Ana Elisa Belotto Morguette, Alexandre Tadachi Morey, Eliandro Reis Tavares, Gilselena Kerbauy, Rosângela S. L. de Almeida Torres, Mauricio Chaves Júnior, Maria Cristina Bronharo Tognim, Viviane Monteiro Góes, Marco Aurélio Krieger, Marcia Regina Eches Perugini, Lucy Megumi Yamauchi and Sueli Fumie Yamada-Ogatta

    Citation: BMC Pregnancy and Childbirth 2018 18:126

    Content type: Research article

    Published on:

  2. Placental mitochondrial DNA (mtDNA) has been proposed to be an indicator for placental hypoxia. This study was designed to evaluate the effect of vascular anastomoses between monochorionic (MC) twins on placen...

    Authors: Yao-Lung Chang, An-Shine Chao, Hsiu-Huei Peng, Shuenn-Dyh Chang, Sheng-Yuan Su, Kuan-Ju Chen and Tzu-Hao Wang

    Citation: BMC Pregnancy and Childbirth 2018 18:74

    Content type: Research article

    Published on:

  3. A hypothesis of preterm parturition is that the pathogenesis of spontaneous preterm birth (sPTB) may be associated with an inflammatory process. Based on this theory, we have hypothesized that an inflammatory ...

    Authors: Guillaume Ducarme, François Desroys du Roure, Aurélie Le Thuaut, Joséphine Grange, Mathilde Vital and Jérôme Dimet

    Citation: BMC Pregnancy and Childbirth 2018 18:65

    Content type: Research article

    Published on:

  4. Routine prenatal care fails to identify a large proportion of women at risk of fetal growth restriction (FGR). Metabolomics, the comprehensive analysis of low molecular weight molecules (metabolites) in biolog...

    Authors: Gauri Luthra, Ivan Vuckovic, A. Bangdiwala, H. Gray, J. B. Redmon, E. S. Barrett, S. Sathyanarayana, R. H. N. Nguyen, S. H. Swan, S. Zhang, P. Dzeja, S. I. Macura and K. S. Nair

    Citation: BMC Pregnancy and Childbirth 2018 18:48

    Content type: Research article

    Published on:

  5. Cell-free DNA (cfDNA) screening has recently acquired tremendous attention, promising patients and healthcare providers a more accurate prenatal screen for aneuploidy than other current screening modalities. I...

    Authors: Wilson V. Chan, Jo-Ann Johnson, R. Douglas Wilson and Amy Metcalfe

    Citation: BMC Pregnancy and Childbirth 2018 18:40

    Content type: Research article

    Published on:

  6. Urinary tract infection is common in pregnancy. Urine is sampled from by mid-stream collection (MSU). If epithelial cells are detected, contamination by vulvo-vagial skin and skin bacteria is assumed. Outside ...

    Authors: N. Liou, J. Currie, C. James, J. Malone-Lee and A. L. David

    Citation: BMC Pregnancy and Childbirth 2017 17:414

    Content type: Research article

    Published on:

  7. In a variety of animal species, hyperthermia in pregnancy has been recognized as teratogenic. Hyperthermia interferes with protein synthesis via heat-shock proteins, which can entail membrane disruption, cell ...

    Authors: L. Sass, S. K. Urhoj, J. Kjærgaard, J. W. Dreier, K. Strandberg-Larsen and A.-M. Nybo Andersen

    Citation: BMC Pregnancy and Childbirth 2017 17:413

    Content type: Research article

    Published on:

  8. Infection induced-inflammation and other risk factors for spontaneous preterm birth (PTB) and preterm premature rupture of membranes (pPROM) may cause a redox imbalance, increasing the release of free radicals...

    Authors: Laura Fernandes Martin, Natália Prearo Moço, Moisés Diôgo de Lima, Jossimara Polettini, Hélio Amante Miot, Camila Renata Corrêa, Ramkumar Menon and Márcia Guimarães da Silva

    Citation: BMC Pregnancy and Childbirth 2017 17:376

    Content type: Research article

    Published on:

  9. Stillbirth after 28 weeks gestation affects between 1.3–8.8 per 1000 births in high-income countries. The majority of stillbirths in this setting occur in women without established risk factors. Identification...

    Authors: Alexander E. P. Heazell, Jane Warland, Tomasina Stacey, Christin Coomarasamy, Jayne Budd, Edwin A. Mitchell and Louise M. O’Brien

    Citation: BMC Pregnancy and Childbirth 2017 17:369

    Content type: Research article

    Published on:

  10. Intrauterine hematomas are a common pregnancy complication. The literature lacks studies about outcomes based on hematoma localization. Thus, we aimed to compare pregnancies complicated by an intraplacental he...

    Authors: Johannes Ott, Philipp Pecnik, Regina Promberger, Sophie Pils, Julia Binder and Kinga M. Chalubinski

    Citation: BMC Pregnancy and Childbirth 2017 17:366

    Content type: Research article

    Published on:

  11. Pregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, blood lipids concentrations...

    Authors: Aisling A. Geraghty, Goiuri Alberdi, Elizabeth J. O’Sullivan, Eileen C. O’Brien, Brenda Crosbie, Patrick J. Twomey and Fionnuala M. McAuliffe

    Citation: BMC Pregnancy and Childbirth 2017 17:360

    Content type: Research article

    Published on:

  12. Widespread endothelial injury contributes to the occurrence of preeclampsia. Maspin, first identified as a tumor suppressor, plays a critical role in cell invasion and angiogenesis. Our previous studies found ...

    Authors: Ying Zhang, Hao Liu, Xinwei Shi, Fuyuan Qiao, Wanjiang Zeng, Ling Feng, Dongrui Deng, Haiyi Liu and Yuanyuan Wu

    Citation: BMC Pregnancy and Childbirth 2017 17:328

    Content type: Research article

    Published on:

  13. Uterine artery pseudoaneurysm (UAP) normally presents genital bleeding in the puerperal period, and severe hydronephrosis rarely presents during pregnancy. We report a rare case of severe ureteral obstruction ...

    Authors: Tsukuru Amano, Shinsuke Tokoro, Shunichiro Tsuji, Takashi Inoue, Fuminori Kimura and Takashi Murakami

    Citation: BMC Pregnancy and Childbirth 2017 17:323

    Content type: Case report

    Published on:

  14. The etiology of pre-eclampsia (PE) is not yet fully understood, though current literature indicates an upregulation of inflammatory mediators produced by the placenta as a potential causal mechanism. Vitamin D...

    Authors: Juhi M. Purswani, Pooja Gala, Pratibha Dwarkanath, Heather M. Larkin, Anura Kurpad and Saurabh Mehta

    Citation: BMC Pregnancy and Childbirth 2017 17:231

    Content type: Research article

    Published on:

  15. Monochorionic twin pregnancies are at increased risk of complications due to sharing a single placenta and potentially developing unbalanced vascular anastomoses. Complications include twin-twin transfusion sy...

    Authors: Fiona L. Mackie, R. Katie Morris and Mark D. Kilby

    Citation: BMC Pregnancy and Childbirth 2017 17:153

    Content type: Study protocol

    Published on:

  16. The oxysterol 27-hydroxycholesterol (27-OHC) plays an important role in the regulation of cholesterol homeostasis. Pregnancy pathologies like preeclampsia (PE), HELLP-syndrome (HELLP), intrauterine growth rest...

    Authors: Brigitte Sophia Winkler, Ulrich Pecks, Laila Najjari, Nicola Kleine-Eggebrecht, Nicolai Maass, Markus Mohaupt and Geneviève Escher

    Citation: BMC Pregnancy and Childbirth 2017 17:106

    Content type: Research article

    Published on:

  17. Parturition at term and preterm is characterized by sterile inflammatory processes occurring in the absence of infection whereby peripheral leukocytes infiltrate gestational tissues in response to chemotactic ...

    Authors: Jun Takeda, Xin Fang and David M. Olson

    Citation: BMC Pregnancy and Childbirth 2017 17:16

    Content type: Research article

    Published on:

  18. Preterm premature rupture of membranes (PPROM) is the largest identifiable cause of preterm birth. There is currently no good screening test for PPROM in low-risk asymptomatic patients. Our goal was to identif...

    Authors: Vanessa Nunes, Jennifer Cross, John E. Speich, Danielle R. Morgan, Jerome F. Strauss III and Ronald M. Ramus

    Citation: BMC Pregnancy and Childbirth 2016 16:387

    Content type: Research article

    Published on:

  19. Preeclampsia and intrauterine fetal growth restriction (IUGR) are two of the most common causes of maternal and perinatal morbidity and mortality. Current methods of predicting those at most risk of these cond...

    Authors: K. M. Groom, L. M. McCowan, P. R. Stone, L. C. Chamley and C. McLintock

    Citation: BMC Pregnancy and Childbirth 2016 16:367

    Content type: Study protocol

    Published on:

  20. The ability to identify patients at risk for developing preeclampsia is important for preventing morbidity and mortality in both the mother and child. Although CYFRA 21–1 (a fragment of Cytokeratin 19) is cons...

    Authors: Lorenz Kuessel, Harald Zeisler, Robin Ristl, Julia Binder, Petra Pateisky, Maximilian Schmid, Julian Marschalek, Thomas Perkmann, Helmuth Haslacher and Heinrich Husslein

    Citation: BMC Pregnancy and Childbirth 2016 16:339

    Content type: Research article

    Published on:

  21. Detection of Ureaplasma, Mycoplasma and Candida spp. in the vagina during pregnancy has previously been associated with preterm birth (PTB). However, the prevalence of these microorganisms and the associated obst...

    Authors: Matthew S. Payne, Demelza J. Ireland, Rory Watts, Elizabeth A. Nathan, Lucy L. Furfaro, Matthew W. Kemp, Jeffrey A. Keelan and John P. Newnham

    Citation: BMC Pregnancy and Childbirth 2016 16:312

    Content type: Research article

    Published on:

  22. Bacterial vaginosis (BV) during pregnancy is a well-established risk factor for preterm birth and other preterm pregnancy complications. Little is known about adverse neonatal outcomes associated with BV expos...

    Authors: Adam S. Dingens, Tessa S. Fairfortune, Susan Reed and Caroline Mitchell

    Citation: BMC Pregnancy and Childbirth 2016 16:278

    Content type: Research article

    Published on:

  23. Drugs used during pregnancy can adversely affect the health and life of the mother and unborn child. However, the fact that drugs are needed to mitigate complications during pregnancy cannot be avoided. The pr...

    Authors: Ramesh Devkota, G. M. Khan, Kadir Alam, Amisha Regmi and Binaya Sapkota

    Citation: BMC Pregnancy and Childbirth 2016 16:272

    Content type: Research article

    Published on:

  24. The influence of different diagnostic thresholds for gestational diabetes mellitus (GDM) on pregnancy outcomes is not fully understood. Degrees of glucose intolerance according to the Carpenter-Coustan (CC) cr...

    Authors: Mei-Chun Lu, Song-Shan Huang, Yuan-Horng Yan and Panchalli Wang

    Citation: BMC Pregnancy and Childbirth 2016 16:231

    Content type: Research article

    Published on:

  25. The fetal anomaly ultrasound only detects 65 to 81 % of the patients with congenital heart disease, making it the most common structural fetal anomaly of which a significant part is missed during prenatal life...

    Authors: Kim M. J. Verdurmen, Carlijn Lempersz, Rik Vullings, Christian Schroer, Tammo Delhaas, Judith O. E. H. van Laar and S. Guid Oei

    Citation: BMC Pregnancy and Childbirth 2016 16:227

    Content type: Study protocol

    Published on:

  26. Spontaneous preterm birth is a complex syndrome with multiple pathways interactions determining its occurrence, including genetic, immunological, physiologic, biochemical and environmental factors. Despite gre...

    Authors: Jose G. Cecatti, Renato T. Souza, Karolina Sulek, Maria L. Costa, Louise C. Kenny, Lesley M. McCowan, Rodolfo C. Pacagnella, Silas G. Villas-Boas, Jussara Mayrink, Renato Passini Jr, Kleber G. Franchini and Philip N. Baker

    Citation: BMC Pregnancy and Childbirth 2016 16:212

    Content type: Study protocol

    Published on:

  27. Adiponectin is an adipocyte hormone involved in energy homeostasis and metabolism. However, its role in early infancy is poorly understood.

    Authors: Zhe-qing Zhang, Qing-gui Lu, Jie Huang, Chang-ya Jiao, Shao-ming Huang and Li-mei Mao

    Citation: BMC Pregnancy and Childbirth 2016 16:189

    Content type: Research article

    Published on:

  28. Evidence suggests that the hormonal milieu of pregnancy is an important determinant of subsequent cancer and other chronic diseases in both the mother and the offspring. Many of the existing maternity and birt...

    Authors: Helena Schock, Anne Zeleniuch-Jacquotte, Eva Lundin, Kjell Grankvist, Hans-Åke Lakso, Annika Idahl, Matti Lehtinen, Heljä-Marja Surcel and Renée T. Fortner

    Citation: BMC Pregnancy and Childbirth 2016 16:146

    Content type: Research article

    Published on:

  29. Prenatal cardiac screening is of great importance as it contributes to appropriate neonatal management and helps parents to make a decision regarding their pregnancy. The aim of our study was to evaluate the e...

    Authors: Ying Zhang, Ai-Lu Cai, Wei-dong Ren, Ya-Jun Guo, Dong-yu Zhang, Wei Sun, Yu Wang, Lei Wang, Yue Qin and Li-ping Huang

    Citation: BMC Pregnancy and Childbirth 2016 16:145

    Content type: Research article

    Published on:

  30. Perinatal depression has a significant impact on both mother and child. However, the influence of hormonal changes during pregnancy and the postpartum period remains unclear. This article provides a systematic...

    Authors: Sunaina Seth, Andrew J. Lewis and Megan Galbally

    Citation: BMC Pregnancy and Childbirth 2016 16:124

    Content type: Research article

    Published on:

  31. Preeclampsia is associated with the placental release of soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG). These anti-angiogenic factors cause hypertension and multi-organ injury. Pravas...

    Authors: Fiona C. Brownfoot, Stephen Tong, Natalie J. Hannan, Roxanne Hastie, Ping Cannon and Tu’uhevaha J. Kaitu’u-Lino

    Citation: BMC Pregnancy and Childbirth 2016 16:117

    Content type: Research article

    Published on:

  32. Gradual increases in mass such as during pregnancy are associated with changes in gait at natural velocities. The purpose of this study was to examine how added mass at natural and imposed slow walking velocit...

    Authors: Simone V. Gill, Maureen Ogamba and Cara L. Lewis

    Citation: BMC Pregnancy and Childbirth 2016 16:109

    Content type: Research article

    Published on:

  33. Retinol-binding protein-4 (RBP4) has been reported to be potentially involved in the pathogenesis of gestational diabetes mellitus (GDM); however, the findings are inconsistent. Our aims were to review the stu...

    Authors: Shimin Hu, Qian Liu, Xin Huang and Hongzhuan Tan

    Citation: BMC Pregnancy and Childbirth 2016 16:52

    Content type: Research article

    Published on:

  34. The dipstick test is widely used as a primary screening test for detection of significant proteinuria in pregnancy (SPIP). However, it often shows a false positive test result. This study was performed to dete...

    Authors: Yosuke Baba, Takahiro Yamada, Mana Obata-Yasuoka, Shun Yasuda, Yasumasa Ohno, Kosuke Kawabata, Shiori Minakawa, Chihiro Hirai, Hideto Kusaka, Nao Murabayashi, Yusuke Inde, Michikazu Nagura, Hiromi Hamada, Atsuo Itakura, Akihide Ohkuchi, Makoto Maeda…

    Citation: BMC Pregnancy and Childbirth 2015 15:331

    Content type: Research article

    Published on:

  35. The British Columbia Perinatal Data Registry (BCPDR) contains individual-level obstetrical and neonatal medical chart data for virtually all births occurring in British Columbia, Canada. The objective of this ...

    Authors: Gillian Frosst, Jennifer Hutcheon, KS Joseph, Brooke Kinniburgh, Cathe Johnson and Lily Lee

    Citation: BMC Pregnancy and Childbirth 2015 15:123

    Content type: Research article

    Published on:

  36. Decolonization with topical antibiotics is necessary to control outbreaks of multidrug-resistant bacterial infection in the Neonatal Intensive Care Unit (NICU), but can trigger bacterial resistance. The object...

    Authors: Fernando Lamy Filho, Sílvia Helena Cavalcante de Sousa, Isolina Januária Sousa Freitas, Zeni Carvalho Lamy, Vanda Maria Ferreira Simões, Antônio Augusto Moura da Silva and Marco Antônio Barbieri

    Citation: BMC Pregnancy and Childbirth 2015 15:63

    Content type: Research article

    Published on:

  37. The development of evidence-based guidelines is a key step in ensuring that maternity care is of a universally high standard. To influence patient care national and international guidelines need to be interpre...

    Authors: Stephanie Jokhan, Melissa K Whitworth, Felicity Jones, Ashleigh Saunders and Alexander E P Heazell

    Citation: BMC Pregnancy and Childbirth 2015 15:54

    Content type: Research article

    Published on:

  38. Preterm premature rupture of membranes (PPROM) is responsible for one third of all preterm births (PTBs). We have recently demonstrated that long noncoding RNAs (lncRNAs) are differentially expressed in human ...

    Authors: Xiucui Luo, Jing Pan, Leilei Wang, Peirong Wang, Meijiao Zhang, Meilin Liu, Ziqing Dong, Qian Meng, Xuguang Tao, Xinliang Zhao, Julia Zhong, Weina Ju, Yang Gu, Edmund C Jenkins, W Ted Brown, Qingxi Shi…

    Citation: BMC Pregnancy and Childbirth 2015 15:35

    Content type: Research article

    Published on:

  39. The purpose of this scoping review was to review the literature on healthcare provider provision of anti-D prophylaxis to RhD negative pregnant women in appropriate clinical situations in various healthcare se...

    Authors: Trina M Fyfe, M Jane Ritchey, Christorina Taruc, Daniel Crompton, Brian Galliford and Rose Perrin

    Citation: BMC Pregnancy and Childbirth 2014 14:411

    Content type: Research article

    Published on:

  40. It is well accepted that the gravid state is hypercoagulable and a significant cause of both maternal morbidity and mortality in the Western world. Although thrombin generation is reported to be increased in p...

    Authors: Jignesh P Patel, Raj K Patel, Lara N Roberts, Michael S Marsh, Bruce Green, J Graham Davies and Roopen Arya

    Citation: BMC Pregnancy and Childbirth 2014 14:384

    Content type: Research article

    Published on:

  41. Antenatal care is of core importance for maternal and child health and is therefore a central aspect of mother and child health care. One of the main goals of effective screening in antenatal care is the detec...

    Authors: Sinja Alexandra Ernst, Anna Reeske, Jacob Spallek, Knud Petersen, Tilman Brand and Hajo Zeeb

    Citation: BMC Pregnancy and Childbirth 2014 14:371

    Content type: Study protocol

    Published on:

  42. B7 costimulatory molecules are expressed on antigen presenting cells (APCs) and are important regulators of T cell activation. We investigated the role of the B7 family of costimulatory molecules in the develo...

    Authors: Enikő Grozdics, László Berta, Anna Bajnok, Gábor Veres, István Ilisz, Péter Klivényi, János Rigó Jr, László Vécsei, Tivadar Tulassay and Gergely Toldi

    Citation: BMC Pregnancy and Childbirth 2014 14:306

    Content type: Research article

    Published on:

  43. Despite the efforts to decrease the rate of preterm birth, preterm delivery is still the main cause of neonatal morbidity and mortality. Identifying patients threatened with preterm delivery remains one of the...

    Authors: Slawomir Wozniak, Piotr Czuczwar, Piotr Szkodziak, Pawel Milart, Ewa Wozniakowska and Tomasz Paszkowski

    Citation: BMC Pregnancy and Childbirth 2014 14:238

    Content type: Research article

    Published on:

  44. The United Kingdom has one of the highest rates of stillbirth in Europe, resulting in approximately 4,000 stillbirths every year. Potentially modifiable risk factors for late stillbirths are maternal age, obes...

    Authors: Jayne Platts, Edwin A Mitchell, Tomasina Stacey, Bill L Martin, Devender Roberts, Lesley McCowan and Alexander E P Heazell

    Citation: BMC Pregnancy and Childbirth 2014 14:171

    Content type: Study protocol

    Published on:

  45. Improvement in ultrasound imaging has led to the identification of subtle non-structural markers during the 18 – 20 week fetal anomaly scan, such as echogenic bowel, mild cerebral ventriculomegaly, renal pelvi...

    Authors: Lisa Hurt, Melissa Wright, Fiona Brook, Susan Thomas, Frank Dunstan, David Fone, Gareth John, Sue Morris, David Tucker, Marilyn Ann Wills, Lyn Chitty, Colin Davies and Shantini Paranjothy

    Citation: BMC Pregnancy and Childbirth 2014 14:164

    Content type: Study protocol

    Published on:

  46. Authors: Mieke LG ten Eikelder, Femke Neervoort, Katrien Oude Rengerink, Gert J van Baaren, Marta Jozwiak, Jan-Willem de Leeuw, Irene de Graaf, Maria G van Pampus, Maureen Franssen, Martijn Oudijk, Paulien van der Salm, Mallory Woiski, Paula JM Pernet, A Hanneke Feitsma, Huib van Vliet, Martina Porath…

    Citation: BMC Pregnancy and Childbirth 2013 13:183

    Content type: Erratum

    Published on:

    The original article was published in BMC Pregnancy and Childbirth 2013 13:67

  47. The use of the ketogenic diet (KD) among women of child-bearing age has been increasing, leading to increased interest in identifying the diet’s suitability during gestation. To date, no studies have thoroughl...

    Authors: Dafna Sussman, Jacob Ellegood and Mark Henkelman

    Citation: BMC Pregnancy and Childbirth 2013 13:198

    Content type: Research article

    Published on:

  48. Previous studies carried out in our laboratories have demonstrated impaired drug permeation in diabetic animals. In this study the permeation of diazepam (after a single dose of 5 mg/day, administered intramus...

    Authors: Mladena Lalic-Popovic, Jovana Paunkovic, Zorica Grujic, Svetlana Golocorbin-Kon, Hani Al-Salami and Momir Mikov

    Citation: BMC Pregnancy and Childbirth 2013 13:188

    Content type: Research article

    Published on:

  49. Nausea and vomiting of pregnancy (NVP) is a common condition. The objective of this study was to evaluate the association between response to antiemetics in the treatment of NVP and genetic polymorphisms in th...

    Authors: Amalia S Lehmann, Jamie L Renbarger, Catherine L McCormick, Ariel R Topletz, Carrie Rouse and David M Haas

    Citation: BMC Pregnancy and Childbirth 2013 13:132

    Content type: Research article

    Published on: