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Biomedical aspects of pregnancy

This section considers studies regarding biomedical and therapeutic aspects of pregnancy.

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  1. Pravastatin, a known inducer of endothelial nitric-oxide synthase (eNOS) was demonstrated in human placenta, however the exact mechanism of it’s action is not fully understood. Since placental NO (nitric oxide...

    Authors: Zita Pánczél, Zoltán Kukor, Dorina Supák, Bence Kovács, András Kecskeméti, Rita Czizel, Magdolna Djurecz, Bálint Alasztics, Krisztián Benedek Csomó, András Hrabák and Sándor Valent

    Citation: BMC Pregnancy and Childbirth 2019 19:426

    Content type: Research article

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  2. It is still uncertain whether surgical evacuation adversely affects subsequent embryo transfer. The present study aims to assess the influence of surgical evacuation on the pregnancy outcomes of subsequent emb...

    Authors: Junan Meng, Mengchen Zhu, Wenjuan Shen, Xiaomin Huang, Haixiang Sun and Jianjun Zhou

    Citation: BMC Pregnancy and Childbirth 2019 19:409

    Content type: Research article

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  3. In Uruguay it is mandatory to review all cases of positive HIV or reactive syphilis tests in pregnancy and peripartum. We compared the rates of mother-to-child transmission of syphilis and HIV detected by case...

    Authors: Susana Cabrera, Mariangela Freitas Silveira, Ana Visconti, Fabian García, Rafael Aguirre, Rodolfo Gomez Ponce de Leon, Jorge Quian and Suzanne J. Serruya

    Citation: BMC Pregnancy and Childbirth 2019 19:400

    Content type: Research article

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  4. Vitamin D plays an important role in human physiology and pathology. The receptor for vitamin D regulates 0.5–5% of the human genome. Accordingly, vitamin D insufficiency has been shown to increase the risk of...

    Authors: Alessio Paffoni, Edgardo Somigliana, Veronica Sarais, Stefania Ferrari, Marco Reschini, Sofia Makieva, Enrico Papaleo and Paola Viganò

    Citation: BMC Pregnancy and Childbirth 2019 19:395

    Content type: Study protocol

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  5. Breast stimulation is performed to self-induce labor. However, there are apparently no reports on hormonal evaluation during stimulation for consecutive days in relation to induction effect. We evaluated the s...

    Authors: Kaori Takahata, Shigeko Horiuchi, Yuriko Tadokoro, Erika Sawano and Kazuyuki Shinohara

    Citation: BMC Pregnancy and Childbirth 2019 19:351

    Content type: Research article

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  6. Preeclampsia is a major cause of maternal, fetal and neonatal morbidity and mortality, particularly in developing countries. Considering the burden of preeclampsia and its associated complications, it is impor...

    Authors: Nisha S. Wadhwani, Deepali P. Sundrani, Girija N. Wagh, Savita S. Mehendale, Manish M. Tipnis, Priscilla C. Joshi, Arun S. Kinare, Sanjay K. Lalwani, Narayanan S. Mani, Nomita Chandhiok, Giriraj R. Chandak, Sanjay A. Gupte, Caroline H. D. Fall and Sadhana R. Joshi

    Citation: BMC Pregnancy and Childbirth 2019 19:308

    Content type: Study protocol

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  7. Recent evidence suggests early screening of preeclampsia and small-for-gestational-age (SGA) would benefit pregnancies followed by subsequent prophylactic use of aspirin. Multi-marker models have shown capabil...

    Authors: Jing Zhang, Luhao Han, Wei Li, Qiaobin Chen, Jie Lei, Min Long, Weibin Yang, Wenya Li, Lizhen Zeng and Sifan Zeng

    Citation: BMC Pregnancy and Childbirth 2019 19:304

    Content type: Research article

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  8. Gestational diabetes mellitus (GDM) is a big health problem that adversely affects both the maternal and perinatal outcomes. We aimed to predict the development of GDM in the first trimester using high sensiti...

    Authors: Warda Naser, Ishag Adam, Duria A. Rayis, Mohammed A. Ahmed and Hamdan Z. Hamdan

    Citation: BMC Pregnancy and Childbirth 2019 19:301

    Content type: Research article

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  9. Oxytocin is a key hormone in childbirth, and synthetic oxytocin is widely administered to induce or speed labour. Due to lack of synthetized knowledge, we conducted a systematic review of maternal plasma level...

    Authors: Kerstin Uvnäs-Moberg, Anette Ekström-Bergström, Marie Berg, Sarah Buckley, Zada Pajalic, Eleni Hadjigeorgiou, Alicja Kotłowska, Luise Lengler, Bogumila Kielbratowska, Fatima Leon-Larios, Claudia Meier Magistretti, Soo Downe, Bengt Lindström and Anna Dencker

    Citation: BMC Pregnancy and Childbirth 2019 19:285

    Content type: Research article

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  10. The prediction of preterm birth (PTB) is important in the management of symptomatic preterm labour women. We evaluated the effectiveness of the foetal fibronectin (fFN) test for predicting PTB in symptomatic p...

    Authors: Soo Yeun Jun, Ji Young Lee, Hyun-Mi Kim, Mi Ju Kim, Hyun-Hwa Cha and Won Joon Seong

    Citation: BMC Pregnancy and Childbirth 2019 19:241

    Content type: Technical advance

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  11. We examined whether inferior thyroid artery peak systolic velocity (ITA-PSV) predicts an increase in levothyroxine (LT4) dosage in pregnant women with Hashimoto’s thyroiditis.

    Authors: Masafumi Kurajoh, Akiyo Yamasaki, Toshiki Nagasaki, Yuki Nagata, Shinsuke Yamada, Yasuo Imanishi, Masanori Emoto, Kanae Takahashi, Kouji Yamamoto, Ayumi Shintani and Masaaki Inaba

    Citation: BMC Pregnancy and Childbirth 2019 19:232

    Content type: Research article

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  12. Early life microflora is an important determinant of immune and metabolic development and may have lasting consequences. However, the mode of delivery and the effect of povidone iodine disinfection on neonatal...

    Authors: Hongping Li, Shaoyun Chen, Lijuan Wu, Huilin Wang, Kelin Xiao, Yanling Gao, Yao Li, Huiqin Li, Bin Xiao and Yuanfang Zhu

    Citation: BMC Pregnancy and Childbirth 2019 19:213

    Content type: Research article

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  13. Children born after intracytoplasmic sperm injection (ICSI) are at increased risk of specific major birth defects compared with children born after in vitro fertilization (IVF). However, whether this risk is d...

    Authors: Seung Chik Jwa, Junna Jwa, Akira Kuwahara, Minoru Irahara, Osamu Ishihara and Hidekazu Saito

    Citation: BMC Pregnancy and Childbirth 2019 19:192

    Content type: Research article

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  14. Preeclampsia is associated with chronic inflammation. The cholinergic anti-inflammatory pathway regulates systemic inflammation through activating α7 nicotinic acetylcholine receptors (α7nAChR) expressed in mo...

    Authors: Hongmei Xu, Qingyang Shi, Yanxiang Mo, Linlin Wu, Jishuang Gu and Ying Xu

    Citation: BMC Pregnancy and Childbirth 2019 19:188

    Content type: Research article

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  15. Tubal pregnancy is recognized as one of the most common ectopic pregnancy types. Salpingitis may result in tubal pregnancy by causing fallopian tube occlusion and hydrosalpinx. B cell activation factor (BAFF) ...

    Authors: Jianying Xu, Xingguang Luo, Shihao Qu, Guiyan Yang and Nianchun Shen

    Citation: BMC Pregnancy and Childbirth 2019 19:169

    Content type: Research article

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  16. Vitamin D deficiency is a growing public health problem, with pregnant women being particularly vulnerable due to its influences on maternal and neonatal outcomes. However, there are limited data published abo...

    Authors: Natalie L. Burke, Emily W. Harville, Jeffrey K. Wickliffe, Arti Shankar, Maureen Y. Lichtveld and Michael L. McCaskill

    Citation: BMC Pregnancy and Childbirth 2019 19:111

    Content type: Research article

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  17. Takotsubo cardiomyopathy is rare in pregnancy and is characterized by left ventricular dysfunction with apical ballooning. This transient cardiac dysfunction may affect women of childbearing age in the antepar...

    Authors: Felix Mwembi Oindi, Evan Sequeira, Herman Ryan Sequeira and Steve Kyende Mutiso

    Citation: BMC Pregnancy and Childbirth 2019 19:89

    Content type: Case report

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  18. Maternal caffeine intake has repeatedly been linked to babies being born small for gestational age (SGA). SGA babies are known to be at increased risk for adverse neonatal outcomes. The aim of this study was t...

    Authors: Dominika Modzelewska, Rino Bellocco, Anders Elfvin, Anne Lise Brantsæter, Helle Margrete Meltzer, Bo Jacobsson and Verena Sengpiel

    Citation: BMC Pregnancy and Childbirth 2019 19:80

    Content type: Research article

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  20. The determination of foetal Rhesus D (RHD) status allows appropriate use of IgRh prophylaxis by restricting its use to cases of RHD feto-maternal incompatibilities. There is a degree of uncertainty about the c...

    Authors: Meryl Darlington, Bruno Carbonne, Agnès Mailloux, Yves Brossard, Annie Levy-Mozziconacci, Anne Cortey, Hassani Maoulida, Tabassome Simon, Alexandra Rousseau and Isabelle Durand-Zaleski

    Citation: BMC Pregnancy and Childbirth 2018 18:496

    Content type: Research article

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  21. Fetal growth restriction is a disorder of placental dysfunction with three to four-fold increased risk of stillbirth. Fetal growth restriction has pathophysiological features in common with preeclampsia. We hy...

    Authors: Teresa M. MacDonald, Chuong Tran, Tu’uhevaha J. Kaitu’u-Lino, Shaun P. Brennecke, Richard J. Hiscock, Lisa Hui, Kirsten M. Dane, Anna L. Middleton, Ping Cannon, Susan P. Walker and Stephen Tong

    Citation: BMC Pregnancy and Childbirth 2018 18:354

    Content type: Research article

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  22. Choosing the optimal season for conception is a part of family planning since it can positively influence the pregnancy outcome. Changes in the monthly number of infants born with a birth defect can signal pre...

    Authors: Miroslav Peterka, Zbynek Likovsky, Ales Panczak and Renata Peterkova

    Citation: BMC Pregnancy and Childbirth 2018 18:348

    Content type: Research article

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  23. We previously reported that fetal plasma erythropoietin (EPO) concentrations are significantly increased in growth-restricted fetuses with abnormal umbilical artery (UA) Doppler. During hypoxia in an ovine mod...

    Authors: Yao-Lung Chang, An-Shine Chao, Hsiu-Huei Peng, Shuenn-Dyh Chang, Kuan-Ju Chen, Po-Jen Cheng and Tzu-Hao Wang

    Citation: BMC Pregnancy and Childbirth 2018 18:321

    Content type: Research article

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  24. The proportion of hyperglycosylated human chorionic gonadotropin (hCG-h) to total human chorionic gonadotropin (%hCG-h) during the first trimester is a promising biomarker for prediction of early-onset pre-ecl...

    Authors: Katja Murtoniemi, Pia M. Villa, Jaakko Matomäki, Elina Keikkala, Piia Vuorela, Esa Hämäläinen, Eero Kajantie, Anu-Katriina Pesonen, Katri Räikkönen, Pekka Taipale, Ulf-Håkan Stenman and Hannele Laivuori

    Citation: BMC Pregnancy and Childbirth 2018 18:279

    Content type: Research article

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  26. Single nucleotide polymorphism of the follicle-stimulating hormone (FSH) receptor (FSHR) is an important marker of ovarian function. However, its role in female fecundity remains debatable. The aim of the stud...

    Authors: Birute Zilaitiene, Marius Dirzauskas, Rasa Verkauskiene, Rytas Ostrauskas, Joerg Gromoll and Eberhard Nieschlag

    Citation: BMC Pregnancy and Childbirth 2018 18:272

    Content type: Research article

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  27. High parity is associated with greater cardiovascular disease (CVD) among mid-life and older women. Prospective studies of arterial change throughout pregnancy are needed to provide insight into potential mech...

    Authors: Nancy Anderson Niemczyk, Marianne Bertolet, Janet M. Catov, Mansi Desai, Candace K. McClure, James M. Roberts, Akira Sekikawa, Ping Guo Tepper and Emma J. Barinas-Mitchell

    Citation: BMC Pregnancy and Childbirth 2018 18:195

    Content type: Research article

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  28. HELLP syndrome is a rare disease in China, and 20% of patients with severe preeclampsia have been accompanied with HELLP syndrome, which is characterized by the presence of hemolysis, elevated liver enzymes an...

    Authors: Qinyue Guo, Zhengfei Yang, Jian Guo, Lei Zhang, Lan Gao, Bo Zhou and Qindong Shi

    Citation: BMC Pregnancy and Childbirth 2018 18:191

    Content type: Case report

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  29. We piloted a randomised controlled trial (RCT) comparing pregnancy outcomes among women with booking gestational diabetes (GDM) receiving immediate or deferred treatment.

    Authors: David Simmons, Jodie Nema, Chloe Parton, Lisa Vizza, Annette Robertson, Rohit Rajagopal, Jane Ussher and Janette Perz

    Citation: BMC Pregnancy and Childbirth 2018 18:151

    Content type: Research article

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  30. Group B Streptococcus (GBS) is the leading cause of septicemia, meningitis, and pneumonia in neonates. Maternal colonization with GBS is the principal risk factor for early-onset disease in infants. Group B St...

    Authors: Solomon Assefa, Kassu Desta and Tsehaynesh Lema

    Citation: BMC Pregnancy and Childbirth 2018 18:135

    Content type: Research article

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  31. Streptococcus agalactiae or Group B Streptococcus (GBS) remains the leading cause of infections in newborns worldwilde. Prenatal GBS screening of pregnant women for vaginal-rectal colonization is recommended in m...

    Authors: Eliane Saori Otaguiri, Ana Elisa Belotto Morguette, Alexandre Tadachi Morey, Eliandro Reis Tavares, Gilselena Kerbauy, Rosângela S. L. de Almeida Torres, Mauricio Chaves Júnior, Maria Cristina Bronharo Tognim, Viviane Monteiro Góes, Marco Aurélio Krieger, Marcia Regina Eches Perugini, Lucy Megumi Yamauchi and Sueli Fumie Yamada-Ogatta

    Citation: BMC Pregnancy and Childbirth 2018 18:126

    Content type: Research article

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  32. Placental mitochondrial DNA (mtDNA) has been proposed to be an indicator for placental hypoxia. This study was designed to evaluate the effect of vascular anastomoses between monochorionic (MC) twins on placen...

    Authors: Yao-Lung Chang, An-Shine Chao, Hsiu-Huei Peng, Shuenn-Dyh Chang, Sheng-Yuan Su, Kuan-Ju Chen and Tzu-Hao Wang

    Citation: BMC Pregnancy and Childbirth 2018 18:74

    Content type: Research article

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  33. A hypothesis of preterm parturition is that the pathogenesis of spontaneous preterm birth (sPTB) may be associated with an inflammatory process. Based on this theory, we have hypothesized that an inflammatory ...

    Authors: Guillaume Ducarme, François Desroys du Roure, Aurélie Le Thuaut, Joséphine Grange, Mathilde Vital and Jérôme Dimet

    Citation: BMC Pregnancy and Childbirth 2018 18:65

    Content type: Research article

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  34. Routine prenatal care fails to identify a large proportion of women at risk of fetal growth restriction (FGR). Metabolomics, the comprehensive analysis of low molecular weight molecules (metabolites) in biolog...

    Authors: Gauri Luthra, Ivan Vuckovic, A. Bangdiwala, H. Gray, J. B. Redmon, E. S. Barrett, S. Sathyanarayana, R. H. N. Nguyen, S. H. Swan, S. Zhang, P. Dzeja, S. I. Macura and K. S. Nair

    Citation: BMC Pregnancy and Childbirth 2018 18:48

    Content type: Research article

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  35. Cell-free DNA (cfDNA) screening has recently acquired tremendous attention, promising patients and healthcare providers a more accurate prenatal screen for aneuploidy than other current screening modalities. I...

    Authors: Wilson V. Chan, Jo-Ann Johnson, R. Douglas Wilson and Amy Metcalfe

    Citation: BMC Pregnancy and Childbirth 2018 18:40

    Content type: Research article

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  36. Urinary tract infection is common in pregnancy. Urine is sampled from by mid-stream collection (MSU). If epithelial cells are detected, contamination by vulvo-vagial skin and skin bacteria is assumed. Outside ...

    Authors: N. Liou, J. Currie, C. James, J. Malone-Lee and A. L. David

    Citation: BMC Pregnancy and Childbirth 2017 17:414

    Content type: Research article

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  37. In a variety of animal species, hyperthermia in pregnancy has been recognized as teratogenic. Hyperthermia interferes with protein synthesis via heat-shock proteins, which can entail membrane disruption, cell ...

    Authors: L. Sass, S. K. Urhoj, J. Kjærgaard, J. W. Dreier, K. Strandberg-Larsen and A.-M. Nybo Andersen

    Citation: BMC Pregnancy and Childbirth 2017 17:413

    Content type: Research article

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  38. Infection induced-inflammation and other risk factors for spontaneous preterm birth (PTB) and preterm premature rupture of membranes (pPROM) may cause a redox imbalance, increasing the release of free radicals...

    Authors: Laura Fernandes Martin, Natália Prearo Moço, Moisés Diôgo de Lima, Jossimara Polettini, Hélio Amante Miot, Camila Renata Corrêa, Ramkumar Menon and Márcia Guimarães da Silva

    Citation: BMC Pregnancy and Childbirth 2017 17:376

    Content type: Research article

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  39. Stillbirth after 28 weeks gestation affects between 1.3–8.8 per 1000 births in high-income countries. The majority of stillbirths in this setting occur in women without established risk factors. Identification...

    Authors: Alexander E. P. Heazell, Jane Warland, Tomasina Stacey, Christin Coomarasamy, Jayne Budd, Edwin A. Mitchell and Louise M. O’Brien

    Citation: BMC Pregnancy and Childbirth 2017 17:369

    Content type: Research article

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  40. Intrauterine hematomas are a common pregnancy complication. The literature lacks studies about outcomes based on hematoma localization. Thus, we aimed to compare pregnancies complicated by an intraplacental he...

    Authors: Johannes Ott, Philipp Pecnik, Regina Promberger, Sophie Pils, Julia Binder and Kinga M. Chalubinski

    Citation: BMC Pregnancy and Childbirth 2017 17:366

    Content type: Research article

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  41. Pregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, blood lipids concentrations...

    Authors: Aisling A. Geraghty, Goiuri Alberdi, Elizabeth J. O’Sullivan, Eileen C. O’Brien, Brenda Crosbie, Patrick J. Twomey and Fionnuala M. McAuliffe

    Citation: BMC Pregnancy and Childbirth 2017 17:360

    Content type: Research article

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  42. Widespread endothelial injury contributes to the occurrence of preeclampsia. Maspin, first identified as a tumor suppressor, plays a critical role in cell invasion and angiogenesis. Our previous studies found ...

    Authors: Ying Zhang, Hao Liu, Xinwei Shi, Fuyuan Qiao, Wanjiang Zeng, Ling Feng, Dongrui Deng, Haiyi Liu and Yuanyuan Wu

    Citation: BMC Pregnancy and Childbirth 2017 17:328

    Content type: Research article

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  43. Uterine artery pseudoaneurysm (UAP) normally presents genital bleeding in the puerperal period, and severe hydronephrosis rarely presents during pregnancy. We report a rare case of severe ureteral obstruction ...

    Authors: Tsukuru Amano, Shinsuke Tokoro, Shunichiro Tsuji, Takashi Inoue, Fuminori Kimura and Takashi Murakami

    Citation: BMC Pregnancy and Childbirth 2017 17:323

    Content type: Case report

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  44. The etiology of pre-eclampsia (PE) is not yet fully understood, though current literature indicates an upregulation of inflammatory mediators produced by the placenta as a potential causal mechanism. Vitamin D...

    Authors: Juhi M. Purswani, Pooja Gala, Pratibha Dwarkanath, Heather M. Larkin, Anura Kurpad and Saurabh Mehta

    Citation: BMC Pregnancy and Childbirth 2017 17:231

    Content type: Research article

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  45. Monochorionic twin pregnancies are at increased risk of complications due to sharing a single placenta and potentially developing unbalanced vascular anastomoses. Complications include twin-twin transfusion sy...

    Authors: Fiona L. Mackie, R. Katie Morris and Mark D. Kilby

    Citation: BMC Pregnancy and Childbirth 2017 17:153

    Content type: Study protocol

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  46. The oxysterol 27-hydroxycholesterol (27-OHC) plays an important role in the regulation of cholesterol homeostasis. Pregnancy pathologies like preeclampsia (PE), HELLP-syndrome (HELLP), intrauterine growth rest...

    Authors: Brigitte Sophia Winkler, Ulrich Pecks, Laila Najjari, Nicola Kleine-Eggebrecht, Nicolai Maass, Markus Mohaupt and Geneviève Escher

    Citation: BMC Pregnancy and Childbirth 2017 17:106

    Content type: Research article

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  47. Parturition at term and preterm is characterized by sterile inflammatory processes occurring in the absence of infection whereby peripheral leukocytes infiltrate gestational tissues in response to chemotactic ...

    Authors: Jun Takeda, Xin Fang and David M. Olson

    Citation: BMC Pregnancy and Childbirth 2017 17:16

    Content type: Research article

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  48. Preterm premature rupture of membranes (PPROM) is the largest identifiable cause of preterm birth. There is currently no good screening test for PPROM in low-risk asymptomatic patients. Our goal was to identif...

    Authors: Vanessa Nunes, Jennifer Cross, John E. Speich, Danielle R. Morgan, Jerome F. Strauss III and Ronald M. Ramus

    Citation: BMC Pregnancy and Childbirth 2016 16:387

    Content type: Research article

    Published on:

  49. Preeclampsia and intrauterine fetal growth restriction (IUGR) are two of the most common causes of maternal and perinatal morbidity and mortality. Current methods of predicting those at most risk of these cond...

    Authors: K. M. Groom, L. M. McCowan, P. R. Stone, L. C. Chamley and C. McLintock

    Citation: BMC Pregnancy and Childbirth 2016 16:367

    Content type: Study protocol

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  50. The ability to identify patients at risk for developing preeclampsia is important for preventing morbidity and mortality in both the mother and child. Although CYFRA 21–1 (a fragment of Cytokeratin 19) is cons...

    Authors: Lorenz Kuessel, Harald Zeisler, Robin Ristl, Julia Binder, Petra Pateisky, Maximilian Schmid, Julian Marschalek, Thomas Perkmann, Helmuth Haslacher and Heinrich Husslein

    Citation: BMC Pregnancy and Childbirth 2016 16:339

    Content type: Research article

    Published on:

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