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BMC Pregnancy and Childbirth

Biomedical aspects of pregnancy

This section considers studies regarding biomedical and therapeutic aspects of pregnancy.

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  1. Content type: Research article

    A hypothesis of preterm parturition is that the pathogenesis of spontaneous preterm birth (sPTB) may be associated with an inflammatory process. Based on this theory, we have hypothesized that an inflammatory ...

    Authors: Guillaume Ducarme, François Desroys du Roure, Aurélie Le Thuaut, Joséphine Grange, Mathilde Vital and Jérôme Dimet

    Citation: BMC Pregnancy and Childbirth 2018 18:65

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  2. Content type: Research article

    Routine prenatal care fails to identify a large proportion of women at risk of fetal growth restriction (FGR). Metabolomics, the comprehensive analysis of low molecular weight molecules (metabolites) in biolog...

    Authors: Gauri Luthra, Ivan Vuckovic, A. Bangdiwala, H. Gray, J. B. Redmon, E. S. Barrett, S. Sathyanarayana, R. H. N. Nguyen, S. H. Swan, S. Zhang, P. Dzeja, S. I. Macura and K. S. Nair

    Citation: BMC Pregnancy and Childbirth 2018 18:48

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  3. Content type: Research article

    Cell-free DNA (cfDNA) screening has recently acquired tremendous attention, promising patients and healthcare providers a more accurate prenatal screen for aneuploidy than other current screening modalities. I...

    Authors: Wilson V. Chan, Jo-Ann Johnson, R. Douglas Wilson and Amy Metcalfe

    Citation: BMC Pregnancy and Childbirth 2018 18:40

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  4. Content type: Research article

    Urinary tract infection is common in pregnancy. Urine is sampled from by mid-stream collection (MSU). If epithelial cells are detected, contamination by vulvo-vagial skin and skin bacteria is assumed. Outside ...

    Authors: N. Liou, J. Currie, C. James, J. Malone-Lee and A. L. David

    Citation: BMC Pregnancy and Childbirth 2017 17:414

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  5. Content type: Research article

    In a variety of animal species, hyperthermia in pregnancy has been recognized as teratogenic. Hyperthermia interferes with protein synthesis via heat-shock proteins, which can entail membrane disruption, cell ...

    Authors: L. Sass, S. K. Urhoj, J. Kjærgaard, J. W. Dreier, K. Strandberg-Larsen and A.-M. Nybo Andersen

    Citation: BMC Pregnancy and Childbirth 2017 17:413

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  6. Content type: Research article

    Stillbirth after 28 weeks gestation affects between 1.3–8.8 per 1000 births in high-income countries. The majority of stillbirths in this setting occur in women without established risk factors. Identification...

    Authors: Alexander E. P. Heazell, Jane Warland, Tomasina Stacey, Christin Coomarasamy, Jayne Budd, Edwin A. Mitchell and Louise M. O’Brien

    Citation: BMC Pregnancy and Childbirth 2017 17:369

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  7. Content type: Research article

    Infection induced-inflammation and other risk factors for spontaneous preterm birth (PTB) and preterm premature rupture of membranes (pPROM) may cause a redox imbalance, increasing the release of free radicals...

    Authors: Laura Fernandes Martin, Natália Prearo Moço, Moisés Diôgo de Lima, Jossimara Polettini, Hélio Amante Miot, Camila Renata Corrêa, Ramkumar Menon and Márcia Guimarães da Silva

    Citation: BMC Pregnancy and Childbirth 2017 17:376

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  8. Content type: Research article

    Intrauterine hematomas are a common pregnancy complication. The literature lacks studies about outcomes based on hematoma localization. Thus, we aimed to compare pregnancies complicated by an intraplacental he...

    Authors: Johannes Ott, Philipp Pecnik, Regina Promberger, Sophie Pils, Julia Binder and Kinga M. Chalubinski

    Citation: BMC Pregnancy and Childbirth 2017 17:366

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  9. Content type: Research article

    Pregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, blood lipids concentrations...

    Authors: Aisling A. Geraghty, Goiuri Alberdi, Elizabeth J. O’Sullivan, Eileen C. O’Brien, Brenda Crosbie, Patrick J. Twomey and Fionnuala M. McAuliffe

    Citation: BMC Pregnancy and Childbirth 2017 17:360

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  10. Content type: Research article

    Widespread endothelial injury contributes to the occurrence of preeclampsia. Maspin, first identified as a tumor suppressor, plays a critical role in cell invasion and angiogenesis. Our previous studies found ...

    Authors: Ying Zhang, Hao Liu, Xinwei Shi, Fuyuan Qiao, Wanjiang Zeng, Ling Feng, Dongrui Deng, Haiyi Liu and Yuanyuan Wu

    Citation: BMC Pregnancy and Childbirth 2017 17:328

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  11. Content type: Case report

    Uterine artery pseudoaneurysm (UAP) normally presents genital bleeding in the puerperal period, and severe hydronephrosis rarely presents during pregnancy. We report a rare case of severe ureteral obstruction ...

    Authors: Tsukuru Amano, Shinsuke Tokoro, Shunichiro Tsuji, Takashi Inoue, Fuminori Kimura and Takashi Murakami

    Citation: BMC Pregnancy and Childbirth 2017 17:323

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  12. Content type: Research article

    The etiology of pre-eclampsia (PE) is not yet fully understood, though current literature indicates an upregulation of inflammatory mediators produced by the placenta as a potential causal mechanism. Vitamin D...

    Authors: Juhi M. Purswani, Pooja Gala, Pratibha Dwarkanath, Heather M. Larkin, Anura Kurpad and Saurabh Mehta

    Citation: BMC Pregnancy and Childbirth 2017 17:231

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  13. Content type: Study protocol

    Monochorionic twin pregnancies are at increased risk of complications due to sharing a single placenta and potentially developing unbalanced vascular anastomoses. Complications include twin-twin transfusion sy...

    Authors: Fiona L. Mackie, R. Katie Morris and Mark D. Kilby

    Citation: BMC Pregnancy and Childbirth 2017 17:153

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  14. Content type: Research article

    The oxysterol 27-hydroxycholesterol (27-OHC) plays an important role in the regulation of cholesterol homeostasis. Pregnancy pathologies like preeclampsia (PE), HELLP-syndrome (HELLP), intrauterine growth rest...

    Authors: Brigitte Sophia Winkler, Ulrich Pecks, Laila Najjari, Nicola Kleine-Eggebrecht, Nicolai Maass, Markus Mohaupt and Geneviève Escher

    Citation: BMC Pregnancy and Childbirth 2017 17:106

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  15. Content type: Research article

    Parturition at term and preterm is characterized by sterile inflammatory processes occurring in the absence of infection whereby peripheral leukocytes infiltrate gestational tissues in response to chemotactic ...

    Authors: Jun Takeda, Xin Fang and David M. Olson

    Citation: BMC Pregnancy and Childbirth 2017 17:16

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  16. Content type: Research article

    Preterm premature rupture of membranes (PPROM) is the largest identifiable cause of preterm birth. There is currently no good screening test for PPROM in low-risk asymptomatic patients. Our goal was to identif...

    Authors: Vanessa Nunes, Jennifer Cross, John E. Speich, Danielle R. Morgan, Jerome F. Strauss III and Ronald M. Ramus

    Citation: BMC Pregnancy and Childbirth 2016 16:387

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  17. Content type: Study protocol

    Preeclampsia and intrauterine fetal growth restriction (IUGR) are two of the most common causes of maternal and perinatal morbidity and mortality. Current methods of predicting those at most risk of these cond...

    Authors: K. M. Groom, L. M. McCowan, P. R. Stone, L. C. Chamley and C. McLintock

    Citation: BMC Pregnancy and Childbirth 2016 16:367

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  18. Content type: Research article

    The ability to identify patients at risk for developing preeclampsia is important for preventing morbidity and mortality in both the mother and child. Although CYFRA 21–1 (a fragment of Cytokeratin 19) is cons...

    Authors: Lorenz Kuessel, Harald Zeisler, Robin Ristl, Julia Binder, Petra Pateisky, Maximilian Schmid, Julian Marschalek, Thomas Perkmann, Helmuth Haslacher and Heinrich Husslein

    Citation: BMC Pregnancy and Childbirth 2016 16:339

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  19. Content type: Research article

    Detection of Ureaplasma, Mycoplasma and Candida spp. in the vagina during pregnancy has previously been associated with preterm birth (PTB). However, the prevalence of these microorganisms and the associated obst...

    Authors: Matthew S. Payne, Demelza J. Ireland, Rory Watts, Elizabeth A. Nathan, Lucy L. Furfaro, Matthew W. Kemp, Jeffrey A. Keelan and John P. Newnham

    Citation: BMC Pregnancy and Childbirth 2016 16:312

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  20. Content type: Research article

    Bacterial vaginosis (BV) during pregnancy is a well-established risk factor for preterm birth and other preterm pregnancy complications. Little is known about adverse neonatal outcomes associated with BV expos...

    Authors: Adam S. Dingens, Tessa S. Fairfortune, Susan Reed and Caroline Mitchell

    Citation: BMC Pregnancy and Childbirth 2016 16:278

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