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Biomedical aspects of pregnancy

This section considers studies regarding biomedical and therapeutic aspects of pregnancy.

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  1. Restorative reproductive medicine (RRM) seeks to identify and correct underlying causes and factors contributing to infertility and reproductive dysfunction. Many components of RRM are highly suitable for prim...

    Authors: Joseph B. Stanford, Paul A. Carpentier, Barbara L. Meier, Mark Rollo and Benjamin Tingey

    Citation: BMC Pregnancy and Childbirth 2021 21:495

    Content type: Research article

    Published on:

  2. Amniotic band syndrome is a rare phenomenon, but it can result in serious complications. We report herein our experience of amniotic band syndrome in a monochorionic diamniotic twin pregnancy where rupture of ...

    Authors: Mizuki Nakashima, Takashi Iizuka, Kyosuke Kagami, Rena Yamazaki, Masanori Ono and Hiroshi Fujiwara

    Citation: BMC Pregnancy and Childbirth 2021 21:456

    Content type: Case report

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  3. This observational clinical study evaluated the expression levels and predictive values of some apoptosis-related genes in granulosa cells (GCs) and follicular fluid (FF) of women undergoing in vitro fertiliza...

    Authors: József Bódis, Endre Sulyok, Ákos Várnagy, Viktória Prémusz, Krisztina Gödöny, Alexandra Makai, Ágnes Szenczi and Timea Varjas

    Citation: BMC Pregnancy and Childbirth 2021 21:399

    Content type: Research article

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  4. Two meta-analyses have shown that pregnancy and birth rates are significantly higher after blastocyst transfer than after cleaved embryo transfer. Other studies have revealed that a serum progesterone level > ...

    Authors: P. Merviel, S. Bouée, A. S. Jacamon, J. J. Chabaud, M. T. Le Martelot, S. Roche, C. Rince, H. Drapier, A. Perrin and D. Beauvillard

    Citation: BMC Pregnancy and Childbirth 2021 21:363

    Content type: Research article

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  5. In assisted reproduction technology embryo competence is routinely evaluated on morphological criteria but efficacy remains relatively low. Additional information could be obtained by evaluating pronuclear (PN...

    Authors: Sara Stigliani, Claudia Massarotti, Francesca Bovis, Ida Casciano, Fausta Sozzi, Valentino Remorgida, Angelo Cagnacci, Paola Anserini and Paola Scaruffi

    Citation: BMC Pregnancy and Childbirth 2021 21:361

    Content type: Research article

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  6. No previous study directly compares the fixed day-5 initiation versus the flexible initiation of GnRH antagonist administration in IVF/ICSI for those patients who are predicted as high ovarian responders witho...

    Authors: Xiu Luo, Li Pei, Fujie Li, Chunli Li, Guoning Huang and Hong Ye

    Citation: BMC Pregnancy and Childbirth 2021 21:348

    Content type: Research article

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  7. Telomere length (TL) is variable at birth and is inversely associated with body mass index (BMI) in adulthood. A growing number of evidences suggested that a higher maternal pre-pregnancy BMI results in advers...

    Authors: Bincai Wei, Yantao Shao, Jun Liang, Peng Tang, Meile Mo, Bihu Liu, Huishen Huang, Hui Juan Jennifer Tan, Dongping Huang, Shun Liu and Xiaoqiang Qiu

    Citation: BMC Pregnancy and Childbirth 2021 21:283

    Content type: Research article

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  8. In monochorionic twin (MC) gestations with selective fetal growth restriction (FGR), the discordant fetal growth usually is due to unequal placental sharing. Glucose, which is essential for oxidative metabolis...

    Authors: Yao-Lung Chang, An-Shine Chao, Shuenn-Dyh Chang and Po-Jen Cheng

    Citation: BMC Pregnancy and Childbirth 2021 21:260

    Content type: Research article

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  9. Along with progress in embryo cryopreservation, especially the vitrification, freeze all strategy has become more acceptable than ever. Some studies have found comparable or higher live birth rate with frozen ...

    Authors: Xiaoyan Ding, Jingwei Yang, Lan Li, Na Yang, Ling Lan, Guoning Huang and Hong Ye

    Citation: BMC Pregnancy and Childbirth 2021 21:207

    Content type: Research article

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  10. The age-specific definition of low anti-müllerian hormone (AMH) is lacking. This study aims to define an age-specific reference for low AMH and to evaluate the associated outcome in women undergoing IVF treatm...

    Authors: Depeng Zhao, Jing Fan, Ping Wang, Xuan Jiang, Jilong Yao and Xuemei Li

    Citation: BMC Pregnancy and Childbirth 2021 21:186

    Content type: Research article

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  11. The interaction of hormonal factors are crucial for good foetal development. During the second trimester of gestation, most of the main physiological processes of foetal development occur. Therefore, the aim o...

    Authors: Silvia Alonso, Sara Caceres, Daniel Vélez, Luis Sanz, Gema Silvan, Maria Jose Illera and Juan Carlos Illera

    Citation: BMC Pregnancy and Childbirth 2021 21:120

    Content type: Research article

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  12. The current study aimed to estimate the prevalence of alcohol use identified as a risk factor during pregnancies by the antenatal care providers, resulting in live births in British Columbia (BC) and to examin...

    Authors: Svetlana Popova, Danijela Dozet, Graham O’Hanlon, Valerie Temple and Jürgen Rehm

    Citation: BMC Pregnancy and Childbirth 2021 21:74

    Content type: Research article

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  13. This study aimed at determining the predictive value of human chorionic gonadotropin and progesterone levels on pregnancy outcomes in patients receiving in vitro fertilization due to fallopian tube associated inf...

    Authors: Wenjia Bo, Ning Zhang, Ling Wang, Ying Guo and Haicui Wu

    Citation: BMC Pregnancy and Childbirth 2021 21:16

    Content type: Research article

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  14. May-Hegglin anomaly is an autosomal dominant inherited condition, characterized by thrombocytopenia, giant platelets and Dohle-like bodies. Incidence is unknown and affected individuals can show from mild to m...

    Authors: Giulio Giordano, Giovanni L. Tiscia, Giovanni Favuzzi, Elena Chinni, Mariano Intrieri, Mario Mastroianno, Letizia Di Meglio, Maurizio Margaglione and Elvira Grandone

    Citation: BMC Pregnancy and Childbirth 2020 20:772

    Content type: Case report

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  15. Preeclampsia is associated with increased arterial stiffness during pregnancy. However, data on the longitudinal change in arterial stiffness after delivery in women with preeclampsia are lacking. In this pilo...

    Authors: Sehun KIM, Hyun Ja LIM, Jeung-Ran KIM, Kyung Joon OH, Joon-Seok HONG and Jung-Won SUH

    Citation: BMC Pregnancy and Childbirth 2020 20:685

    Content type: Research article

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  16. Human implantation is a complex process requiring synchrony between a healthy embryo and a functionally competent or receptive endometrium. In order to assess endometrial receptivity in Assisted Reproductive T...

    Authors: Renato Silva Martins, António Helio Oliani, Denise Vaz Oliani and José Martinez de Oliveira

    Citation: BMC Pregnancy and Childbirth 2020 20:663

    Content type: Research article

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  17. Multiple pregnancies are associated with significant complications and health risks for both mothers and infants. Single blastocyst transfer (SBT) is a logical and effective measure to reduce the incidence of ...

    Authors: Shiping Chen, Hongzi Du, Jianqiao Liu, Haiying Liu, Lei Li and Yuxia He

    Citation: BMC Pregnancy and Childbirth 2020 20:655

    Content type: Research article

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  18. This cross-sectional study aimed to evaluate the levels of tumor necrosis factor-alpha (TNF-ɑ), interleukin-8 (IL-8), interleukin-6 (IL-6), and transforming growth factor-beta 1 (TGF-β1) in patients with prima...

    Authors: Jiacong Yan, Chengbo Liu, Han Zhao, Chunyan Wang, Huimei Yao, Qiong Lu, Jia Liu and Yun Feng

    Citation: BMC Pregnancy and Childbirth 2020 20:644

    Content type: Research article

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  19. Four-dimensional hysterosalpingo-contrast sonography (4D-HyCoSy) is the preferred way for evaluating fallopian tubal patency and it associated with higher rate of spontaneous conception. However, Few studies h...

    Authors: Yu Liu, Ning Zhang, Yanni He, Jiayao Shi, Meijun Zhou, Jingjiao Xu and Hongmei Liu

    Citation: BMC Pregnancy and Childbirth 2020 20:638

    Content type: Research article

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  20. Recent studies have suggested that fetal sex influences maternal glucose and insulin metabolism during pregnancy. We examined whether fetal sex is associated with maternal insulin resistance and the β-cell fun...

    Authors: Hiroshi Yamashita, Ichiro Yasuhi, Megumi Koga, So Sugimi, Yasushi Umezaki, Misao Fukuoka, Sachie Suga, Masashi Fukuda and Nobuko Kusuda

    Citation: BMC Pregnancy and Childbirth 2020 20:560

    Content type: Research article

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  21. Intrahepatic cholestasis of pregnancy (ICP) is characterized by pruritus and cholestasis in late pregnancy and results in adverse pregnancy outcomes, including preterm delivery and birth weight, which are affe...

    Authors: Xianxian Liu, Hua Lai, Xiaoming Zeng, Siming Xin, Liju Nie, Zhenyi Liang, Meiling Wu, Yu Chen, Jiusheng Zheng and Yang Zou

    Citation: BMC Pregnancy and Childbirth 2020 20:544

    Content type: Research article

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  22. Displacement of the window of implantation (WOI) has been proposed as an important factor contributing to repeated implantation failure (RIF). However, the use of histologic endometrial dating as a diagnostic ...

    Authors: Yuan Li, Xiao feng Li, Jing nan Liao, Xiang xiu Fan, Yong bin Hu, Runxin Gan, Guangxiu Lu, Ge Lin and Fei Gong

    Citation: BMC Pregnancy and Childbirth 2020 20:527

    Content type: Research article

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  23. There is a growing body of evidence regarding the association between Adiponectin and mental disorders. We aim to evaluate the association between serum level of Adiponectin hormone and postpartum depression a...

    Authors: Fattaneh Pahlavan, Anoshirvan Kazemnejad, Fatemeh Razavinia, Seyedeh Razieh Fazeli Daryasari and Najmeh Tahranian

    Citation: BMC Pregnancy and Childbirth 2020 20:525

    Content type: Research article

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  24. There is no definitive evidence about the suitable timing to transfer blastocysts formed and cryopreserved on day 6 (D6 blastocysts) in frozen-thawed embryo transfer (FET) cycles. This study aimed to investiga...

    Authors: Huiling Xu, Shumin Qiu, Xiaojing Chen, Suqin Zhu, Yan Sun and Beihong Zheng

    Citation: BMC Pregnancy and Childbirth 2020 20:519

    Content type: Research article

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  25. The prevalence of Gestational Diabetes (GDM) is rising and with it the number of mothers and children at risk of adverse outcomes. As treatment has been shown to reduce adverse events, it is imperative that we...

    Authors: D. Bogdanet, PM. O’Shea, J. Halperin and F. Dunne

    Citation: BMC Pregnancy and Childbirth 2020 20:412

    Content type: Study protocol

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  26. Amniotic fluid embolism (AFE), also known as anaphylactoid syndrome of pregnancy (ASP), typically occurs during labor and may result in cardiorespiratory collapse and disseminated intravascular coagulation (DI...

    Authors: Mayumi Kamata, Tetsuo Maruyama, Tomizo Nishiguchi and Shinya Iwasaki

    Citation: BMC Pregnancy and Childbirth 2020 20:406

    Content type: Case report

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    The Correction to this article has been published in BMC Pregnancy and Childbirth 2020 20:430

  27. Umbilical cord blood (UCB) has been proposed as the potential source of haematopoietic stem cells (HSC) for allogeneic transplantation. However, few studies have shown that a common disease in pregnancy such a...

    Authors: Fazlina Nordin, Mohd Razif Mohd Idris, Zaleha Abdullah Mahdy and S. Fadilah Abd Wahid

    Citation: BMC Pregnancy and Childbirth 2020 20:399

    Content type: Research article

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  28. The purpose of this research is to summarize the prenatal ultrasound characteristics of congenital duodenal obstruction (CDO), especially in the diagnosis of duodenal diaphragm and annular pancreas. At present...

    Authors: Chan Yin, Lili Tong, Mingxiang Ma, Xiaoqun Tan, Guoliang Luo, Zhihui Fei and Dan Nie

    Citation: BMC Pregnancy and Childbirth 2020 20:387

    Content type: Research article

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  29. There has been debate about the existence of lymphatic vessels in placenta. Lymphatic endothelial cell (LEC) markers such as LYVE-1 and podoplanin/D2–40 have been found, although PROX1 has not been detected. T...

    Authors: Jürgen Becker, Gilles E. Tchagou Tchangou, Sonja Schmidt, Christina Zelent, Fritz Kahl and Jörg Wilting

    Citation: BMC Pregnancy and Childbirth 2020 20:380

    Content type: Research article

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  30. Gestational diabetes mellitus (GDM) is associated with adverse diabetic complications for both mother and child during pregnancy. The common Gold Standard (GS) for diagnosis of GDM is 75 g oral glucose toleran...

    Authors: Maedeh Amini, Anoshirvan Kazemnejad, Farid Zayeri, Ali Montazeri, Aliakbar Rasekhi, Azam Amirian and Nourossadat Kariman

    Citation: BMC Pregnancy and Childbirth 2020 20:375

    Content type: Research article

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  31. A high incidence of posterior reversible encephalopathy syndrome (PRES) has been observed in women with eclampsia on imaging. However this association was documented mostly after convulsions occurred. This stu...

    Authors: An-Shine Chao, Yao-Liang Chen, Yao-Lung Chang, Angel Chao, Seng-Yuan Su and Tzu-Hao Wang

    Citation: BMC Pregnancy and Childbirth 2020 20:336

    Content type: Research article

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  32. Many studies have demonstrated the benefits of the addition of growth hormone (GH) to the controlled ovarian stimulation protocol in vitro fertilization (IVF) cycles in poor-respond patients, but the effect of...

    Authors: Jingyu Li, Qiaoli Chen, Jiang Wang, Guoning Huang and Hong Ye

    Citation: BMC Pregnancy and Childbirth 2020 20:310

    Content type: Research article

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  33. Candida is the leading cause of vaginitis, and 75% of women have at least one episode of infection in their lives, with pregnancy being a predisposing factor. If left untreated, vulvovaginal candidiasis (VVC) can...

    Authors: Sayanika Devi Waikhom, Innocent Afeke, Grace Sefakor Kwawu, Hintermann Kobina Mbroh, George Yiadom Osei, Bengyella Louis, John Gameli Deku, Emmanuel Senyo Kasu, Prosper Mensah, Charles Yao Agede, Cornelius Dodoo, Emmanuel Akomanin Asiamah, John Tampuori, John Korbuvi and Japheth Awuletey Opintan

    Citation: BMC Pregnancy and Childbirth 2020 20:266

    Content type: Research article

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  34. Probiotic supplementation has been shown to be beneficial and is now widely promoted as an auxiliary medicine for maternal health, but the underlying mechanism is still unclear. Thus, this study aimed to explo...

    Authors: Ping Yang, Zhe Li, Kian Deng Tye, Yuyi Chen, Tong Lu, Zonglin He, Juan Zhou and Xiaomin Xiao

    Citation: BMC Pregnancy and Childbirth 2020 20:216

    Content type: Research article

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  35. Both follicle stimulating hormone (FSH) and anti-mullerian hormone (AMH) are widely used to assess the ovarian reserve in women for in vitro fertilization (IVF). However, studies also showed that both AMH and ...

    Authors: Han-Chih Hsieh, Jia-Ying Su, Shunping Wang and Yen-Tsung Huang

    Citation: BMC Pregnancy and Childbirth 2020 20:209

    Content type: Research Article

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  36. Geophagia although pleasurable and somewhat a necessity among pregnant women, also comes along with its own attendant problems such as exposure to potentially hazardous substances like bacteria, fungi, helmint...

    Authors: Nii Korley Kortei, Alice Koryo-Dabrah, Papa Toah Akonor, Nana Yaw Barimah Manaphraim, Matilda Ayim-Akonor, Nathaniel Owusu Boadi, Edward Ken Essuman and Clement Tettey

    Citation: BMC Pregnancy and Childbirth 2020 20:160

    Content type: Research article

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  37. Currently, there are many studies researched the associations between maternal serum inflammatory indicators (i.e. ferritin, C-reactive protein [CRP], C3 and C4) and preterm birth (PTB). The results, however, ...

    Authors: Shengzhu Huang, Jiarong Tian, Chaoqun Liu, Yu Long, Dehao Cao, Luyun Wei, Xiujuan Zhu, Ruiqiang Tang, Weiwu Liu, Dingyuan Zeng, Mujun Li, Xiaobo Yang and Zengnan Mo

    Citation: BMC Pregnancy and Childbirth 2020 20:131

    Content type: Research article

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  38. Non-obstetric surgery conducted during pregnancy may increase the risk of adverse birth outcomes like small for gestational age, preterm birth, and miscarriage. Mechanisms are unclear but possibly longer lasti...

    Authors: Anne Staub Rasmussen, Christian Fynbo Christiansen, Niels Uldbjerg and Mette Nørgaard

    Citation: BMC Pregnancy and Childbirth 2020 20:108

    Content type: Research article

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  39. It is well known that second-trimester maternal serum alpha-fetoprotein (MS-AFP) is a predictor for adverse pregnancy outcomes (APOs), such as preterm birth, stillbirth, preeclampsia and small for gestational ...

    Authors: Jilin Hu, Jinman Zhang, Guilin He, Shu Zhu, Xinhua Tang, Jie Su, Qian Li, Yamin Kong and Baosheng Zhu

    Citation: BMC Pregnancy and Childbirth 2020 20:104

    Content type: Research article

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  40. CXCL12(chemokine ligand 12, CXCL12) and its receptors CXCR4 are widely expressed in maternal-fetal interface and plays an adjust role in materno-fetal dialogue and immune tolerance during early pregnancy. This...

    Authors: Jiayi Zheng, Danni Qu, Chen Wang, Ling Ding and Wenhui Zhou

    Citation: BMC Pregnancy and Childbirth 2020 20:87

    Content type: Research article

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  41. Gestational diabetes mellitus (GDM) is a growing global epidemic. Our study aims to confirm the association between circulatory coiled-coil domain-containing 80 (CCDC80) in pregnant women with GDM, to investig...

    Authors: Lei Liu, Jiajin Hu, Ningning Wang, Yang Liu, Xiaotong Wei, Ming Gao, Yanan Ma and Deliang Wen

    Citation: BMC Pregnancy and Childbirth 2020 20:53

    Content type: Research article

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  42. Many efforts have been focused on the alternative glycemic marker glycated albumin (GlyA) and its application in pregnancy during which profound physiological changes take place. Our objective was to determine...

    Authors: Ying Dong, Yanhong Zhai, Jing Wang, Yi Chen, Xin Xie, Chunhong Zhang, Jingrui Liu, Yifan Lu, Guodong Tang, Lican Han, Lin Li and Zheng Cao

    Citation: BMC Pregnancy and Childbirth 2020 20:12

    Content type: Research article

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  43. Premature birth is the main cause of mortality in children under 1 year, and vitamin D deficiency during gestation is associated with prematurity. The effects of vitamin D are mediated by its receptor, which i...

    Authors: Letícia Veríssimo Dutra, Fernando Alves Affonso-Kaufman, Fernanda Ramires Cafeo, Milene Saori Kassai, Caio Parente Barbosa, Francisco Winter Santos Figueiredo, Fabíola Isabel Suano-Souza and Bianca Bianco

    Citation: BMC Pregnancy and Childbirth 2019 20:3

    Content type: Research article

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  44. Group B Streptococcus (GBS) is one of the most important causative agents of neonatal sepsis. As administration of prophylactic antibiotics during labor can prevent GBS infection, routine screening for this bacte...

    Authors: Laura L. Vieira, Amanda V. Perez, Monique M. Machado, Michele L. Kayser, Daniela V. Vettori, Ana Paula Alegretti, Charles F. Ferreira, Janete Vettorazzi and Edimárlei G. Valério

    Citation: BMC Pregnancy and Childbirth 2019 19:532

    Content type: Research article

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  45. Candida is the commonest opportunistic fungi in human. Candida species cause diverse types of diseases. Vaginal candidiasis has been reported as one of the most common type of fungal diseases among pregnant women...

    Authors: Alem Tsega and Feleke Mekonnen

    Citation: BMC Pregnancy and Childbirth 2019 19:527

    Content type: Research article

    Published on:

  46. Myocardial deformation imaging offers the potential to measure myocardial function. Remodelling, the change in size, shape and function, appears as a result of pressure or volume changes and is thought to be t...

    Authors: Noortje H. M. van Oostrum, S. Guid Oei and Judith O. E. H. van Laar

    Citation: BMC Pregnancy and Childbirth 2019 19:524

    Content type: Study protocol

    Published on:

  47. Pregnancy management in women with Wilson disease (WD) remains an important clinical problem. This research was conducted to investigate how to avoid worsening of WD symptoms during pregnancy and increase preg...

    Authors: Xu-En Yu, Min Pan, Yong-Zhu Han, Ren-Min Yang, Juan Wang and Shan Gao

    Citation: BMC Pregnancy and Childbirth 2019 19:522

    Content type: Research article

    Published on:

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