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Biomedical aspects of pregnancy

This section considers studies regarding biomedical and therapeutic aspects of pregnancy.

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  1. Content type: Research article

    The determination of foetal Rhesus D (RHD) status allows appropriate use of IgRh prophylaxis by restricting its use to cases of RHD feto-maternal incompatibilities. There is a degree of uncertainty about the c...

    Authors: Meryl Darlington, Bruno Carbonne, Agnès Mailloux, Yves Brossard, Annie Levy-Mozziconacci, Anne Cortey, Hassani Maoulida, Tabassome Simon, Alexandra Rousseau and Isabelle Durand-Zaleski

    Citation: BMC Pregnancy and Childbirth 2018 18:496

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  2. Content type: Research article

    Fetal growth restriction is a disorder of placental dysfunction with three to four-fold increased risk of stillbirth. Fetal growth restriction has pathophysiological features in common with preeclampsia. We hy...

    Authors: Teresa M. MacDonald, Chuong Tran, Tu’uhevaha J. Kaitu’u-Lino, Shaun P. Brennecke, Richard J. Hiscock, Lisa Hui, Kirsten M. Dane, Anna L. Middleton, Ping Cannon, Susan P. Walker and Stephen Tong

    Citation: BMC Pregnancy and Childbirth 2018 18:354

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  3. Content type: Research article

    Choosing the optimal season for conception is a part of family planning since it can positively influence the pregnancy outcome. Changes in the monthly number of infants born with a birth defect can signal pre...

    Authors: Miroslav Peterka, Zbynek Likovsky, Ales Panczak and Renata Peterkova

    Citation: BMC Pregnancy and Childbirth 2018 18:348

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  4. Content type: Research article

    We previously reported that fetal plasma erythropoietin (EPO) concentrations are significantly increased in growth-restricted fetuses with abnormal umbilical artery (UA) Doppler. During hypoxia in an ovine mod...

    Authors: Yao-Lung Chang, An-Shine Chao, Hsiu-Huei Peng, Shuenn-Dyh Chang, Kuan-Ju Chen, Po-Jen Cheng and Tzu-Hao Wang

    Citation: BMC Pregnancy and Childbirth 2018 18:321

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  5. Content type: Research article

    The proportion of hyperglycosylated human chorionic gonadotropin (hCG-h) to total human chorionic gonadotropin (%hCG-h) during the first trimester is a promising biomarker for prediction of early-onset pre-ecl...

    Authors: Katja Murtoniemi, Pia M. Villa, Jaakko Matomäki, Elina Keikkala, Piia Vuorela, Esa Hämäläinen, Eero Kajantie, Anu-Katriina Pesonen, Katri Räikkönen, Pekka Taipale, Ulf-Håkan Stenman and Hannele Laivuori

    Citation: BMC Pregnancy and Childbirth 2018 18:279

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  6. Content type: Research article

    Single nucleotide polymorphism of the follicle-stimulating hormone (FSH) receptor (FSHR) is an important marker of ovarian function. However, its role in female fecundity remains debatable. The aim of the stud...

    Authors: Birute Zilaitiene, Marius Dirzauskas, Rasa Verkauskiene, Rytas Ostrauskas, Joerg Gromoll and Eberhard Nieschlag

    Citation: BMC Pregnancy and Childbirth 2018 18:272

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  7. Content type: Research article

    High parity is associated with greater cardiovascular disease (CVD) among mid-life and older women. Prospective studies of arterial change throughout pregnancy are needed to provide insight into potential mech...

    Authors: Nancy Anderson Niemczyk, Marianne Bertolet, Janet M. Catov, Mansi Desai, Candace K. McClure, James M. Roberts, Akira Sekikawa, Ping Guo Tepper and Emma J. Barinas-Mitchell

    Citation: BMC Pregnancy and Childbirth 2018 18:195

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  8. Content type: Case report

    HELLP syndrome is a rare disease in China, and 20% of patients with severe preeclampsia have been accompanied with HELLP syndrome, which is characterized by the presence of hemolysis, elevated liver enzymes an...

    Authors: Qinyue Guo, Zhengfei Yang, Jian Guo, Lei Zhang, Lan Gao, Bo Zhou and Qindong Shi

    Citation: BMC Pregnancy and Childbirth 2018 18:191

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  9. Content type: Research article

    We piloted a randomised controlled trial (RCT) comparing pregnancy outcomes among women with booking gestational diabetes (GDM) receiving immediate or deferred treatment.

    Authors: David Simmons, Jodie Nema, Chloe Parton, Lisa Vizza, Annette Robertson, Rohit Rajagopal, Jane Ussher and Janette Perz

    Citation: BMC Pregnancy and Childbirth 2018 18:151

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  10. Content type: Research article

    Group B Streptococcus (GBS) is the leading cause of septicemia, meningitis, and pneumonia in neonates. Maternal colonization with GBS is the principal risk factor for early-onset disease in infants. Group B St...

    Authors: Solomon Assefa, Kassu Desta and Tsehaynesh Lema

    Citation: BMC Pregnancy and Childbirth 2018 18:135

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  11. Content type: Research article

    Streptococcus agalactiae or Group B Streptococcus (GBS) remains the leading cause of infections in newborns worldwilde. Prenatal GBS screening of pregnant women for vaginal-rectal colonization is recommended in m...

    Authors: Eliane Saori Otaguiri, Ana Elisa Belotto Morguette, Alexandre Tadachi Morey, Eliandro Reis Tavares, Gilselena Kerbauy, Rosângela S. L. de Almeida Torres, Mauricio Chaves Júnior, Maria Cristina Bronharo Tognim, Viviane Monteiro Góes, Marco Aurélio Krieger, Marcia Regina Eches Perugini, Lucy Megumi Yamauchi and Sueli Fumie Yamada-Ogatta

    Citation: BMC Pregnancy and Childbirth 2018 18:126

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  12. Content type: Research article

    Placental mitochondrial DNA (mtDNA) has been proposed to be an indicator for placental hypoxia. This study was designed to evaluate the effect of vascular anastomoses between monochorionic (MC) twins on placen...

    Authors: Yao-Lung Chang, An-Shine Chao, Hsiu-Huei Peng, Shuenn-Dyh Chang, Sheng-Yuan Su, Kuan-Ju Chen and Tzu-Hao Wang

    Citation: BMC Pregnancy and Childbirth 2018 18:74

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  13. Content type: Research article

    A hypothesis of preterm parturition is that the pathogenesis of spontaneous preterm birth (sPTB) may be associated with an inflammatory process. Based on this theory, we have hypothesized that an inflammatory ...

    Authors: Guillaume Ducarme, François Desroys du Roure, Aurélie Le Thuaut, Joséphine Grange, Mathilde Vital and Jérôme Dimet

    Citation: BMC Pregnancy and Childbirth 2018 18:65

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  14. Content type: Research article

    Routine prenatal care fails to identify a large proportion of women at risk of fetal growth restriction (FGR). Metabolomics, the comprehensive analysis of low molecular weight molecules (metabolites) in biolog...

    Authors: Gauri Luthra, Ivan Vuckovic, A. Bangdiwala, H. Gray, J. B. Redmon, E. S. Barrett, S. Sathyanarayana, R. H. N. Nguyen, S. H. Swan, S. Zhang, P. Dzeja, S. I. Macura and K. S. Nair

    Citation: BMC Pregnancy and Childbirth 2018 18:48

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  15. Content type: Research article

    Cell-free DNA (cfDNA) screening has recently acquired tremendous attention, promising patients and healthcare providers a more accurate prenatal screen for aneuploidy than other current screening modalities. I...

    Authors: Wilson V. Chan, Jo-Ann Johnson, R. Douglas Wilson and Amy Metcalfe

    Citation: BMC Pregnancy and Childbirth 2018 18:40

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  16. Content type: Research article

    Urinary tract infection is common in pregnancy. Urine is sampled from by mid-stream collection (MSU). If epithelial cells are detected, contamination by vulvo-vagial skin and skin bacteria is assumed. Outside ...

    Authors: N. Liou, J. Currie, C. James, J. Malone-Lee and A. L. David

    Citation: BMC Pregnancy and Childbirth 2017 17:414

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  17. Content type: Research article

    In a variety of animal species, hyperthermia in pregnancy has been recognized as teratogenic. Hyperthermia interferes with protein synthesis via heat-shock proteins, which can entail membrane disruption, cell ...

    Authors: L. Sass, S. K. Urhoj, J. Kjærgaard, J. W. Dreier, K. Strandberg-Larsen and A.-M. Nybo Andersen

    Citation: BMC Pregnancy and Childbirth 2017 17:413

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  18. Content type: Research article

    Stillbirth after 28 weeks gestation affects between 1.3–8.8 per 1000 births in high-income countries. The majority of stillbirths in this setting occur in women without established risk factors. Identification...

    Authors: Alexander E. P. Heazell, Jane Warland, Tomasina Stacey, Christin Coomarasamy, Jayne Budd, Edwin A. Mitchell and Louise M. O’Brien

    Citation: BMC Pregnancy and Childbirth 2017 17:369

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  19. Content type: Research article

    Infection induced-inflammation and other risk factors for spontaneous preterm birth (PTB) and preterm premature rupture of membranes (pPROM) may cause a redox imbalance, increasing the release of free radicals...

    Authors: Laura Fernandes Martin, Natália Prearo Moço, Moisés Diôgo de Lima, Jossimara Polettini, Hélio Amante Miot, Camila Renata Corrêa, Ramkumar Menon and Márcia Guimarães da Silva

    Citation: BMC Pregnancy and Childbirth 2017 17:376

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  20. Content type: Research article

    Intrauterine hematomas are a common pregnancy complication. The literature lacks studies about outcomes based on hematoma localization. Thus, we aimed to compare pregnancies complicated by an intraplacental he...

    Authors: Johannes Ott, Philipp Pecnik, Regina Promberger, Sophie Pils, Julia Binder and Kinga M. Chalubinski

    Citation: BMC Pregnancy and Childbirth 2017 17:366

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  21. Content type: Research article

    Pregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, blood lipids concentrations...

    Authors: Aisling A. Geraghty, Goiuri Alberdi, Elizabeth J. O’Sullivan, Eileen C. O’Brien, Brenda Crosbie, Patrick J. Twomey and Fionnuala M. McAuliffe

    Citation: BMC Pregnancy and Childbirth 2017 17:360

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  22. Content type: Research article

    Widespread endothelial injury contributes to the occurrence of preeclampsia. Maspin, first identified as a tumor suppressor, plays a critical role in cell invasion and angiogenesis. Our previous studies found ...

    Authors: Ying Zhang, Hao Liu, Xinwei Shi, Fuyuan Qiao, Wanjiang Zeng, Ling Feng, Dongrui Deng, Haiyi Liu and Yuanyuan Wu

    Citation: BMC Pregnancy and Childbirth 2017 17:328

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  23. Content type: Case report

    Uterine artery pseudoaneurysm (UAP) normally presents genital bleeding in the puerperal period, and severe hydronephrosis rarely presents during pregnancy. We report a rare case of severe ureteral obstruction ...

    Authors: Tsukuru Amano, Shinsuke Tokoro, Shunichiro Tsuji, Takashi Inoue, Fuminori Kimura and Takashi Murakami

    Citation: BMC Pregnancy and Childbirth 2017 17:323

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  24. Content type: Research article

    The etiology of pre-eclampsia (PE) is not yet fully understood, though current literature indicates an upregulation of inflammatory mediators produced by the placenta as a potential causal mechanism. Vitamin D...

    Authors: Juhi M. Purswani, Pooja Gala, Pratibha Dwarkanath, Heather M. Larkin, Anura Kurpad and Saurabh Mehta

    Citation: BMC Pregnancy and Childbirth 2017 17:231

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  25. Content type: Study protocol

    Monochorionic twin pregnancies are at increased risk of complications due to sharing a single placenta and potentially developing unbalanced vascular anastomoses. Complications include twin-twin transfusion sy...

    Authors: Fiona L. Mackie, R. Katie Morris and Mark D. Kilby

    Citation: BMC Pregnancy and Childbirth 2017 17:153

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  26. Content type: Research article

    The oxysterol 27-hydroxycholesterol (27-OHC) plays an important role in the regulation of cholesterol homeostasis. Pregnancy pathologies like preeclampsia (PE), HELLP-syndrome (HELLP), intrauterine growth rest...

    Authors: Brigitte Sophia Winkler, Ulrich Pecks, Laila Najjari, Nicola Kleine-Eggebrecht, Nicolai Maass, Markus Mohaupt and Geneviève Escher

    Citation: BMC Pregnancy and Childbirth 2017 17:106

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  27. Content type: Research article

    Parturition at term and preterm is characterized by sterile inflammatory processes occurring in the absence of infection whereby peripheral leukocytes infiltrate gestational tissues in response to chemotactic ...

    Authors: Jun Takeda, Xin Fang and David M. Olson

    Citation: BMC Pregnancy and Childbirth 2017 17:16

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  28. Content type: Research article

    Preterm premature rupture of membranes (PPROM) is the largest identifiable cause of preterm birth. There is currently no good screening test for PPROM in low-risk asymptomatic patients. Our goal was to identif...

    Authors: Vanessa Nunes, Jennifer Cross, John E. Speich, Danielle R. Morgan, Jerome F. Strauss III and Ronald M. Ramus

    Citation: BMC Pregnancy and Childbirth 2016 16:387

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  29. Content type: Study protocol

    Preeclampsia and intrauterine fetal growth restriction (IUGR) are two of the most common causes of maternal and perinatal morbidity and mortality. Current methods of predicting those at most risk of these cond...

    Authors: K. M. Groom, L. M. McCowan, P. R. Stone, L. C. Chamley and C. McLintock

    Citation: BMC Pregnancy and Childbirth 2016 16:367

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  30. Content type: Research article

    The ability to identify patients at risk for developing preeclampsia is important for preventing morbidity and mortality in both the mother and child. Although CYFRA 21–1 (a fragment of Cytokeratin 19) is cons...

    Authors: Lorenz Kuessel, Harald Zeisler, Robin Ristl, Julia Binder, Petra Pateisky, Maximilian Schmid, Julian Marschalek, Thomas Perkmann, Helmuth Haslacher and Heinrich Husslein

    Citation: BMC Pregnancy and Childbirth 2016 16:339

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  31. Content type: Research article

    Detection of Ureaplasma, Mycoplasma and Candida spp. in the vagina during pregnancy has previously been associated with preterm birth (PTB). However, the prevalence of these microorganisms and the associated obst...

    Authors: Matthew S. Payne, Demelza J. Ireland, Rory Watts, Elizabeth A. Nathan, Lucy L. Furfaro, Matthew W. Kemp, Jeffrey A. Keelan and John P. Newnham

    Citation: BMC Pregnancy and Childbirth 2016 16:312

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  32. Content type: Research article

    Bacterial vaginosis (BV) during pregnancy is a well-established risk factor for preterm birth and other preterm pregnancy complications. Little is known about adverse neonatal outcomes associated with BV expos...

    Authors: Adam S. Dingens, Tessa S. Fairfortune, Susan Reed and Caroline Mitchell

    Citation: BMC Pregnancy and Childbirth 2016 16:278

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  33. Content type: Research article

    Drugs used during pregnancy can adversely affect the health and life of the mother and unborn child. However, the fact that drugs are needed to mitigate complications during pregnancy cannot be avoided. The pr...

    Authors: Ramesh Devkota, G. M. Khan, Kadir Alam, Amisha Regmi and Binaya Sapkota

    Citation: BMC Pregnancy and Childbirth 2016 16:272

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  34. Content type: Study protocol

    The fetal anomaly ultrasound only detects 65 to 81 % of the patients with congenital heart disease, making it the most common structural fetal anomaly of which a significant part is missed during prenatal life...

    Authors: Kim M. J. Verdurmen, Carlijn Lempersz, Rik Vullings, Christian Schroer, Tammo Delhaas, Judith O. E. H. van Laar and S. Guid Oei

    Citation: BMC Pregnancy and Childbirth 2016 16:227

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  35. Content type: Research article

    The influence of different diagnostic thresholds for gestational diabetes mellitus (GDM) on pregnancy outcomes is not fully understood. Degrees of glucose intolerance according to the Carpenter-Coustan (CC) cr...

    Authors: Mei-Chun Lu, Song-Shan Huang, Yuan-Horng Yan and Panchalli Wang

    Citation: BMC Pregnancy and Childbirth 2016 16:231

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  36. Content type: Study protocol

    Spontaneous preterm birth is a complex syndrome with multiple pathways interactions determining its occurrence, including genetic, immunological, physiologic, biochemical and environmental factors. Despite gre...

    Authors: Jose G. Cecatti, Renato T. Souza, Karolina Sulek, Maria L. Costa, Louise C. Kenny, Lesley M. McCowan, Rodolfo C. Pacagnella, Silas G. Villas-Boas, Jussara Mayrink, Renato Passini Jr, Kleber G. Franchini and Philip N. Baker

    Citation: BMC Pregnancy and Childbirth 2016 16:212

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  37. Content type: Research article

    Adiponectin is an adipocyte hormone involved in energy homeostasis and metabolism. However, its role in early infancy is poorly understood.

    Authors: Zhe-qing Zhang, Qing-gui Lu, Jie Huang, Chang-ya Jiao, Shao-ming Huang and Li-mei Mao

    Citation: BMC Pregnancy and Childbirth 2016 16:189

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  38. Content type: Research article

    Evidence suggests that the hormonal milieu of pregnancy is an important determinant of subsequent cancer and other chronic diseases in both the mother and the offspring. Many of the existing maternity and birt...

    Authors: Helena Schock, Anne Zeleniuch-Jacquotte, Eva Lundin, Kjell Grankvist, Hans-Åke Lakso, Annika Idahl, Matti Lehtinen, Heljä-Marja Surcel and Renée T. Fortner

    Citation: BMC Pregnancy and Childbirth 2016 16:146

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  39. Content type: Research article

    Prenatal cardiac screening is of great importance as it contributes to appropriate neonatal management and helps parents to make a decision regarding their pregnancy. The aim of our study was to evaluate the e...

    Authors: Ying Zhang, Ai-Lu Cai, Wei-dong Ren, Ya-Jun Guo, Dong-yu Zhang, Wei Sun, Yu Wang, Lei Wang, Yue Qin and Li-ping Huang

    Citation: BMC Pregnancy and Childbirth 2016 16:145

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  40. Content type: Research article

    Perinatal depression has a significant impact on both mother and child. However, the influence of hormonal changes during pregnancy and the postpartum period remains unclear. This article provides a systematic...

    Authors: Sunaina Seth, Andrew J. Lewis and Megan Galbally

    Citation: BMC Pregnancy and Childbirth 2016 16:124

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  41. Content type: Research article

    Preeclampsia is associated with the placental release of soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG). These anti-angiogenic factors cause hypertension and multi-organ injury. Pravas...

    Authors: Fiona C. Brownfoot, Stephen Tong, Natalie J. Hannan, Roxanne Hastie, Ping Cannon and Tu’uhevaha J. Kaitu’u-Lino

    Citation: BMC Pregnancy and Childbirth 2016 16:117

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  42. Content type: Research article

    Gradual increases in mass such as during pregnancy are associated with changes in gait at natural velocities. The purpose of this study was to examine how added mass at natural and imposed slow walking velocit...

    Authors: Simone V. Gill, Maureen Ogamba and Cara L. Lewis

    Citation: BMC Pregnancy and Childbirth 2016 16:109

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  43. Content type: Research article

    Retinol-binding protein-4 (RBP4) has been reported to be potentially involved in the pathogenesis of gestational diabetes mellitus (GDM); however, the findings are inconsistent. Our aims were to review the stu...

    Authors: Shimin Hu, Qian Liu, Xin Huang and Hongzhuan Tan

    Citation: BMC Pregnancy and Childbirth 2016 16:52

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  44. Content type: Research article

    The dipstick test is widely used as a primary screening test for detection of significant proteinuria in pregnancy (SPIP). However, it often shows a false positive test result. This study was performed to dete...

    Authors: Yosuke Baba, Takahiro Yamada, Mana Obata-Yasuoka, Shun Yasuda, Yasumasa Ohno, Kosuke Kawabata, Shiori Minakawa, Chihiro Hirai, Hideto Kusaka, Nao Murabayashi, Yusuke Inde, Michikazu Nagura, Hiromi Hamada, Atsuo Itakura, Akihide Ohkuchi, Makoto Maeda…

    Citation: BMC Pregnancy and Childbirth 2015 15:331

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  45. Content type: Research article

    The British Columbia Perinatal Data Registry (BCPDR) contains individual-level obstetrical and neonatal medical chart data for virtually all births occurring in British Columbia, Canada. The objective of this ...

    Authors: Gillian Frosst, Jennifer Hutcheon, KS Joseph, Brooke Kinniburgh, Cathe Johnson and Lily Lee

    Citation: BMC Pregnancy and Childbirth 2015 15:123

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  46. Content type: Research article

    Decolonization with topical antibiotics is necessary to control outbreaks of multidrug-resistant bacterial infection in the Neonatal Intensive Care Unit (NICU), but can trigger bacterial resistance. The object...

    Authors: Fernando Lamy Filho, Sílvia Helena Cavalcante de Sousa, Isolina Januária Sousa Freitas, Zeni Carvalho Lamy, Vanda Maria Ferreira Simões, Antônio Augusto Moura da Silva and Marco Antônio Barbieri

    Citation: BMC Pregnancy and Childbirth 2015 15:63

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  47. Content type: Research article

    The development of evidence-based guidelines is a key step in ensuring that maternity care is of a universally high standard. To influence patient care national and international guidelines need to be interpre...

    Authors: Stephanie Jokhan, Melissa K Whitworth, Felicity Jones, Ashleigh Saunders and Alexander E P Heazell

    Citation: BMC Pregnancy and Childbirth 2015 15:54

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  48. Content type: Research article

    Preterm premature rupture of membranes (PPROM) is responsible for one third of all preterm births (PTBs). We have recently demonstrated that long noncoding RNAs (lncRNAs) are differentially expressed in human ...

    Authors: Xiucui Luo, Jing Pan, Leilei Wang, Peirong Wang, Meijiao Zhang, Meilin Liu, Ziqing Dong, Qian Meng, Xuguang Tao, Xinliang Zhao, Julia Zhong, Weina Ju, Yang Gu, Edmund C Jenkins, W Ted Brown, Qingxi Shi…

    Citation: BMC Pregnancy and Childbirth 2015 15:35

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