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Biomedical aspects of pregnancy

This section considers studies regarding biomedical and therapeutic aspects of pregnancy.

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  1. Content type: Research article

    High parity is associated with greater cardiovascular disease (CVD) among mid-life and older women. Prospective studies of arterial change throughout pregnancy are needed to provide insight into potential mech...

    Authors: Nancy Anderson Niemczyk, Marianne Bertolet, Janet M. Catov, Mansi Desai, Candace K. McClure, James M. Roberts, Akira Sekikawa, Ping Guo Tepper and Emma J. Barinas-Mitchell

    Citation: BMC Pregnancy and Childbirth 2018 18:195

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  2. Content type: Case report

    HELLP syndrome is a rare disease in China, and 20% of patients with severe preeclampsia have been accompanied with HELLP syndrome, which is characterized by the presence of hemolysis, elevated liver enzymes an...

    Authors: Qinyue Guo, Zhengfei Yang, Jian Guo, Lei Zhang, Lan Gao, Bo Zhou and Qindong Shi

    Citation: BMC Pregnancy and Childbirth 2018 18:191

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  3. Content type: Research article

    We piloted a randomised controlled trial (RCT) comparing pregnancy outcomes among women with booking gestational diabetes (GDM) receiving immediate or deferred treatment.

    Authors: David Simmons, Jodie Nema, Chloe Parton, Lisa Vizza, Annette Robertson, Rohit Rajagopal, Jane Ussher and Janette Perz

    Citation: BMC Pregnancy and Childbirth 2018 18:151

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  4. Content type: Research article

    Group B Streptococcus (GBS) is the leading cause of septicemia, meningitis, and pneumonia in neonates. Maternal colonization with GBS is the principal risk factor for early-onset disease in infants. Group B St...

    Authors: Solomon Assefa, Kassu Desta and Tsehaynesh Lema

    Citation: BMC Pregnancy and Childbirth 2018 18:135

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  5. Content type: Research article

    Streptococcus agalactiae or Group B Streptococcus (GBS) remains the leading cause of infections in newborns worldwilde. Prenatal GBS screening of pregnant women for vaginal-rectal colonization is recommended in m...

    Authors: Eliane Saori Otaguiri, Ana Elisa Belotto Morguette, Alexandre Tadachi Morey, Eliandro Reis Tavares, Gilselena Kerbauy, Rosângela S. L. de Almeida Torres, Mauricio Chaves Júnior, Maria Cristina Bronharo Tognim, Viviane Monteiro Góes, Marco Aurélio Krieger, Marcia Regina Eches Perugini, Lucy Megumi Yamauchi and Sueli Fumie Yamada-Ogatta

    Citation: BMC Pregnancy and Childbirth 2018 18:126

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  6. Content type: Research article

    Placental mitochondrial DNA (mtDNA) has been proposed to be an indicator for placental hypoxia. This study was designed to evaluate the effect of vascular anastomoses between monochorionic (MC) twins on placen...

    Authors: Yao-Lung Chang, An-Shine Chao, Hsiu-Huei Peng, Shuenn-Dyh Chang, Sheng-Yuan Su, Kuan-Ju Chen and Tzu-Hao Wang

    Citation: BMC Pregnancy and Childbirth 2018 18:74

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  7. Content type: Research article

    A hypothesis of preterm parturition is that the pathogenesis of spontaneous preterm birth (sPTB) may be associated with an inflammatory process. Based on this theory, we have hypothesized that an inflammatory ...

    Authors: Guillaume Ducarme, François Desroys du Roure, Aurélie Le Thuaut, Joséphine Grange, Mathilde Vital and Jérôme Dimet

    Citation: BMC Pregnancy and Childbirth 2018 18:65

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  8. Content type: Research article

    Routine prenatal care fails to identify a large proportion of women at risk of fetal growth restriction (FGR). Metabolomics, the comprehensive analysis of low molecular weight molecules (metabolites) in biolog...

    Authors: Gauri Luthra, Ivan Vuckovic, A. Bangdiwala, H. Gray, J. B. Redmon, E. S. Barrett, S. Sathyanarayana, R. H. N. Nguyen, S. H. Swan, S. Zhang, P. Dzeja, S. I. Macura and K. S. Nair

    Citation: BMC Pregnancy and Childbirth 2018 18:48

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  9. Content type: Research article

    Cell-free DNA (cfDNA) screening has recently acquired tremendous attention, promising patients and healthcare providers a more accurate prenatal screen for aneuploidy than other current screening modalities. I...

    Authors: Wilson V. Chan, Jo-Ann Johnson, R. Douglas Wilson and Amy Metcalfe

    Citation: BMC Pregnancy and Childbirth 2018 18:40

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  10. Content type: Research article

    Urinary tract infection is common in pregnancy. Urine is sampled from by mid-stream collection (MSU). If epithelial cells are detected, contamination by vulvo-vagial skin and skin bacteria is assumed. Outside ...

    Authors: N. Liou, J. Currie, C. James, J. Malone-Lee and A. L. David

    Citation: BMC Pregnancy and Childbirth 2017 17:414

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  11. Content type: Research article

    In a variety of animal species, hyperthermia in pregnancy has been recognized as teratogenic. Hyperthermia interferes with protein synthesis via heat-shock proteins, which can entail membrane disruption, cell ...

    Authors: L. Sass, S. K. Urhoj, J. Kjærgaard, J. W. Dreier, K. Strandberg-Larsen and A.-M. Nybo Andersen

    Citation: BMC Pregnancy and Childbirth 2017 17:413

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  12. Content type: Research article

    Stillbirth after 28 weeks gestation affects between 1.3–8.8 per 1000 births in high-income countries. The majority of stillbirths in this setting occur in women without established risk factors. Identification...

    Authors: Alexander E. P. Heazell, Jane Warland, Tomasina Stacey, Christin Coomarasamy, Jayne Budd, Edwin A. Mitchell and Louise M. O’Brien

    Citation: BMC Pregnancy and Childbirth 2017 17:369

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  13. Content type: Research article

    Infection induced-inflammation and other risk factors for spontaneous preterm birth (PTB) and preterm premature rupture of membranes (pPROM) may cause a redox imbalance, increasing the release of free radicals...

    Authors: Laura Fernandes Martin, Natália Prearo Moço, Moisés Diôgo de Lima, Jossimara Polettini, Hélio Amante Miot, Camila Renata Corrêa, Ramkumar Menon and Márcia Guimarães da Silva

    Citation: BMC Pregnancy and Childbirth 2017 17:376

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  14. Content type: Research article

    Intrauterine hematomas are a common pregnancy complication. The literature lacks studies about outcomes based on hematoma localization. Thus, we aimed to compare pregnancies complicated by an intraplacental he...

    Authors: Johannes Ott, Philipp Pecnik, Regina Promberger, Sophie Pils, Julia Binder and Kinga M. Chalubinski

    Citation: BMC Pregnancy and Childbirth 2017 17:366

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  15. Content type: Research article

    Pregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, blood lipids concentrations...

    Authors: Aisling A. Geraghty, Goiuri Alberdi, Elizabeth J. O’Sullivan, Eileen C. O’Brien, Brenda Crosbie, Patrick J. Twomey and Fionnuala M. McAuliffe

    Citation: BMC Pregnancy and Childbirth 2017 17:360

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  16. Content type: Research article

    Widespread endothelial injury contributes to the occurrence of preeclampsia. Maspin, first identified as a tumor suppressor, plays a critical role in cell invasion and angiogenesis. Our previous studies found ...

    Authors: Ying Zhang, Hao Liu, Xinwei Shi, Fuyuan Qiao, Wanjiang Zeng, Ling Feng, Dongrui Deng, Haiyi Liu and Yuanyuan Wu

    Citation: BMC Pregnancy and Childbirth 2017 17:328

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  17. Content type: Case report

    Uterine artery pseudoaneurysm (UAP) normally presents genital bleeding in the puerperal period, and severe hydronephrosis rarely presents during pregnancy. We report a rare case of severe ureteral obstruction ...

    Authors: Tsukuru Amano, Shinsuke Tokoro, Shunichiro Tsuji, Takashi Inoue, Fuminori Kimura and Takashi Murakami

    Citation: BMC Pregnancy and Childbirth 2017 17:323

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  18. Content type: Research article

    The etiology of pre-eclampsia (PE) is not yet fully understood, though current literature indicates an upregulation of inflammatory mediators produced by the placenta as a potential causal mechanism. Vitamin D...

    Authors: Juhi M. Purswani, Pooja Gala, Pratibha Dwarkanath, Heather M. Larkin, Anura Kurpad and Saurabh Mehta

    Citation: BMC Pregnancy and Childbirth 2017 17:231

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  19. Content type: Study protocol

    Monochorionic twin pregnancies are at increased risk of complications due to sharing a single placenta and potentially developing unbalanced vascular anastomoses. Complications include twin-twin transfusion sy...

    Authors: Fiona L. Mackie, R. Katie Morris and Mark D. Kilby

    Citation: BMC Pregnancy and Childbirth 2017 17:153

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  20. Content type: Research article

    The oxysterol 27-hydroxycholesterol (27-OHC) plays an important role in the regulation of cholesterol homeostasis. Pregnancy pathologies like preeclampsia (PE), HELLP-syndrome (HELLP), intrauterine growth rest...

    Authors: Brigitte Sophia Winkler, Ulrich Pecks, Laila Najjari, Nicola Kleine-Eggebrecht, Nicolai Maass, Markus Mohaupt and Geneviève Escher

    Citation: BMC Pregnancy and Childbirth 2017 17:106

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