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Table 3 Mediation effect of pregnancy-induced hypertension (PIH) in the relationship between assisted reproductive technology (ART) and adverse neonatal outcomes

From: Mediation effect of pregnancy-induced hypertension on the association between assisted reproductive technology and adverse neonatal outcomes: a population-based study

Outcomes

Populations

Model 1

Model 2

Model 3

Distribution-of-the-product (95% CI)

Indirect Effect

(95% CI)

Percentage Mediated (%)

OR (95% CI)

OR1 (95% CI)

OR2 (95% CI)

Adverse neonatal outcomes

Total

1.45 (1.42–1.49)

1.47 (1.43–1.51)

1.43 (1.39–1.47)

0.31 (0.28–0.34)

1.37 (1.33–1.41)

8.51

Age < 35 years

1.43 (1.37–1.49)

1.59 (1.52–1.66)

1.55 (1.48–1.61)

0.32 (0.28–0.37)

1.38 (1.32–1.45)

6.78

Age ≥ 35 years

1.34 (1.29–1.39)

1.42 (1.37–1.47)

1.37 (1.33–1.42)

0.37 (0.33–0.41)

1.44 (1.39–1.50)

11.90

Primipara

1.41 (1.37–1.46)

1.42 (1.37–1.47)

1.37 (1.32–1.42)

0.31 (0.28–0.35)

1.37 (1.32–1.42)

11.90

Multipara

1.41 (1.36–1.47)

1.53 (1.47–1.60)

1.49 (1.43–1.56)

0.38 (0.32–0.43)

1.46 (1.38–1.54)

7.55

Low birth weight

Total

1.24 (1.19–1.30)

1.24 (1.19–1.30)

1.17 (1.12–1.23)

0.45 (0.41–0.50)

1.57 (1.51–1.64)

29.17

Age < 35 years

1.20 (1.12–1.29)

1.36 (1.26–1.45)

1.29 (1.20–1.38)

0.47 (0.40–0.54)

1.60 (1.49–1.71)

19.44

Age ≥ 35 years

1.20 (1.13–1.27)

1.21 (1.14–1.28)

1.14 (1.08–1.21)

0.51 (0.46–0.57)

1.67 (1.58–1.77)

33.33

Primipara

1.17 (1.11–1.23)

1.19 (1.13–1.26)

1.12 (1.06–1.19)

0.46 (0.41–0.51)

1.58 (1.50–1.67)

36.84

Multipara

1.15 (1.07–1.24)

1.30 (1.21–1.40)

1.24 (1.15–1.34)

0.53 (0.46–0.60)

1.70 (1.58–1.83)

20.00

Premature birth

Total

1.48 (1.44–1.53)

1.64 (1.58–1.69)

1.58 (1.53–1.64)

0.33 (0.30–0.37)

1.40 (1.35–1.44)

9.37

Age < 35 years

1.41 (1.34–1.49)

1.77 (1.68–1.86)

1.71 (1.62–1.81)

0.35 (0.30–0.40)

1.41 (1.34–1.48)

7.79

Age ≥ 35 years

1.34 (1.29–1.39)

1.56 (1.50–1.63)

1.50 (1.44–1.57)

0.38 (0.34–0.43)

1.47 (1.41–1.53)

10.71

Primipara

1.50 (1.43–1.56)

1.58 (1.51–1.65)

1.52 (1.45–1.59)

0.35 (0.31–0.39)

1.42 (1.36–1.48)

10.34

Multipara

1.52 (1.45–1.59)

1.71 (1.63–1.79)

1.66 (1.58–1.74)

0.38 (0.33–0.43)

1.46 (1.39–1.54)

7.04

NICU admission

Total

1.60 (1.55–1.66)

1.41 (1.36–1.46)

1.36 (1.32–1.41)

0.30 (0.27–0.33)

1.35 (1.31–1.38)

12.20

Age < 35 years

1.60 (1.51–1.68)

1.53 (1.44–1.61)

1.48 (1.40–1.56)

0.30 (0.26–0.35)

1.36 (1.30–1.42)

9.43

Age ≥ 35 years

1.44 (1.38–1.50)

1.42 (1.36–1.49)

1.38 (1.31–1.44)

0.35 (0.31–0.38)

1.41 (1.36–1.47)

9.52

Primipara

1.53 (1.47–1.60)

1.41 (1.35–1.48)

1.37 (1.31–1.43)

0.29 (0.25–0.32)

1.33 (1.29–1.38)

9.76

Multipara

1.48 (1.40–1.57)

1.39 (1.32–1.48)

1.35 (1.28–1.43)

0.37 (0.31–0.42)

1.44 (1.37–1.52)

10.26

  1. Note: OR, odds ratio; 95%CI, 95% confidence interval; model 1, univariate logistic regression model; model 2, multivariate logistic regression model adjusted for maternal age at delivery (not in age subgroups), race of mother, educational level of mother, marital status, age of father, race of father, educational level of father, smoking before pregnancy, smoking during pregnancy, total number of prenatal care visits for this pregnancy, pre-pregnancy BMI, pre-pregnancy chronic diabetes, gestational diabetes, clinical chorioamnionitis or maternal fever during labor, previous preterm births, previous cesarean section, parity (not in parity subgroups), and gestational weight gain; model 3 further adjusted for PIH (intermediate variable) based on model 2; NICU, neonatal intensive care unit
  2. *Percentage mediated: The percentages of mediated explained by PIH were calculated using the formula (OR1 - OR2) / (OR1–1) * 100