Effect of levothyroxine treatment on fetal growth among women with mild subclinical hypothyroidism and thyroid peroxidase antibody negative: a cohort study

Table 4 Comparison of fetal growth and birth weight Z-scores between the LT4 treated mild SCH and untreated mild SCH group

	Untreated mild SCH with TPOAb⁻	Treated mild SCH with TPOAb⁻
		Model 1 ^a		Model 2 ^b
		β (95%CI)	P value	β (95%CI)	P value
AC	ref	-0.120(-0.333, 0.094)	0.271	-0.129(-0.346, 0.088)	0.244
BPD	ref	-0.209(-0.424, 0.006)	0.056	-0.206(-0.422, 0.010)	0.062
FL	ref	0.010(-0.205, 0.226)	0.925	-0.007(-0.226, 0.212)	0.951
HC	ref	-0.249(-0.471, -0.027)	0.028	-0.236(-0.457, -0.015)	0.036
EFW	ref	-0.136(-0.360, 0.087)	0.233	-0.146(-0.373, 0.080)	0.206
Birth weight	ref	-0.057(-0.317, 0.204)	0.670	-0.065(-0.329, 0.199)	0.628

Abbreviations: AC abdominal circumference, BPD biparietal diameter, FL femur length, HC head circumference, EFW estimate fetal weight
Bold indicated P < 0.05
^aThe model 1 was adjusted for the covariates including maternal age, maternal educational levels, current employment status, parity, pre-pregnancy BMI and gestational age of thyroid function testing
^bThe model 2 was additionally adjusted for TSH level

ISSN: 1471-2393