Skip to main content

Table 1 Comparison of the maternal and child characteristics among the 3 groups

From: Effect of levothyroxine treatment on fetal growth among women with mild subclinical hypothyroidism and thyroid peroxidase antibody negative: a cohort study

 

Euthyroid (n = 14,285)

Untreated mild SCH (n = 248)

Treated mild SCH (n = 76)

P Value

Maternal age (years)

29.4(27.1–32.2)

29.6(27–32.8)

30(27.1–31.9)

0.833

Maternal education levels

   

0.116

 Low (high school and below)

2200(15.4)

46(18.5)

5(6.6)

 

 Middle (vocational college)

6166(43.2)

109(44)

34(44.7)

 

 High (university and above)

5919(41.4)

93(37.5)

37(48.7)

 

Current employment status

   

0.045

 Yes

12,590(88.1)

219(88.3)

74(97.4)

 

 No

1695(11.9)

29(11.7)

2(2.6)

 

Parity

   

0.002

 Primipara

8029(56.2)

161(64.9) a

52(68.4)

 

 Multipara

6256(43.8)

87(35.1) a

24(31.6)

 

Pre-pregnancy BMI

   

0.725

 Underweight

1371(9.6)

21(8.5)

5(6.6)

 

 Normal weight

9303(65.1)

157(63.3)

47(61.8)

 

 Overweight

2821(19.7)

54(21.8)

18(23.7)

 

 Obesity

790(5.5)

16(6.5)

6(7.9)

 

 Gestational age at thyroid function testing (weeks)

8.9(8–10.1)

8.8(8–10.6)

8.7(7.9–10.5)

0.828

 TSH (mIU/L)

0.90(0.51–1.34)

2.67(2.56–2.77) a

2.71(2.61–2.81) b

 < 0.001

 FT4 (pmol/L)

13.64(12.67–14.77)

12.93(12.09–13.74) a

12.94(11.88–13.78) b

 < 0.001

 Gestational age at delivery (weeks)

39.6(38.9–40.4)

39.9(39.1–40.7)

39.9(39–40.6)

0.058

Gender

   

0.073

 Girls

6951(48.7)

106(42.7)

31(40.8)

 

 Boys

7334(51.3)

142(57.3)

45(59.2)

 

 Birth weight (g)

3370(3100–3660)

3365(3107.5–3680)

3395(3095–3622.5)

0.992

  1. Continuous variables were expressed as median and IQR and compared using Kruskal–Wallis H test, categorical variables were presented as the frequency (percentage) and compared using the Chi-square test or Fisher exact test among the 3 groups, with post hoc Bonferroni corrections, P = 0.05/3
  2. Abbreviations: TSH thyroid stimulating hormone, FT4 free thyroxine, BMI body mass index
  3. Bold indicated P < 0.05
  4. aP values < 0.017 between untreated mild SCH and euthyroid
  5. bP values < 0.017 between treated mild SCH and euthyroid