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Table 3 Use of supplementation on changes in iron status and odds of postpartum iron deficiency and anaemia 1

From: The impact of recommending iron supplements to women with depleted iron stores in early pregnancy on use of supplements, and factors associated with changes in iron status from early pregnancy to postpartum in a multi-ethnic population-based cohort

Linear regression: change in SF, sTfR, TBI, and Hb concentration

Logistic regression: postpartum iron deficiency or anaemia

 

Unadjusted model

Final linear model a

 

Unadjusted model

Final logistic model a

β

95% CI

p-value

Adj β

95% CI

p-value

 

OR

95% CI

p-value

Adj OR

95% CI

p-value

Recommended supplements (SF < 20 μg/L at enrolment in early pregnancy)

Recommended supplements (SF < 20 μg/L at enrolment in early pregnancy)

Self-reported use of supplementation in GW 28

Self-reported use of supplementation in GW 28

Change in SF

5.7

1.0, 10

0.018

5.1

0.2, 10.0

0.040

Postpartum ID by SF

0.6

0.3, 1.0

0.047

0.5

0.3, 1.0

0.044

Change in sTfR

-0.7

-1.2, -0.3

0.003

-0.7

-1.2, -0.2

0.009

Postpartum ID by sTfR

0.9

0.5, 1.6

0.665

0.6

0.3, 1.3

0.221

Change in TBI

2.1

1.1, 3.2

< 0.001

1.8

0.7, 2.9

0.001

Postpartum ID by TBI

0.4

0.2, 0.8

0.005

0.3

0.1, 0.6

0.001

Change in Hb

0.5

0.3, 0.8

< 0.001

0.6

0.4, 0.9

< 0.001

Postpartum anaemia

0.8

0,5, 1.5

0.560

0.7

0.4, 1.4

0.348

SF ≥ 20 μg/L at enrolment in early pregnancy (not exposed to recommendations)

SF ≥ 20 μg/L at enrolment in early pregnancy (not exposed to recommendations)

Self-reported use of iron supplementation in GW 28

Self-reported use of supplementation in GW 28

Change in SF

18.6

10, 21

< 0.001

5.1

0.5, 9.6

0.029

Postpartum ID by SF

0.4

0.2, 0.8

0.004

0.4

0.2, 0.7

0.004

Change in sTfR

-0.5

-0.9, -0.1

0.011

-0.6

-1.0, -0.2

0.007

Postpartum ID by sTfR

0.4

0.1, 0.9

0.039

0.3

0.91, 0.9

0.027

Change in TBI

2.2

1.3, 3.2

< 0.001

1.8

0.9, 2.7

< 0.001

Postpartum ID by TBI

0.3

0.1, 0.7

0.006

0.3

0.1, 0.6

0.001

Change in Hb

0.3

0.1, 0.6

0.010

0.4

0.2, 0.7

0.001

Postpartum anaemia

1.1

0.6, 2.0

0.854

0.9

0.5, 19

0.854

  1. Adj Adjusted, β beta, 95% CI 95% confidence interval, enrolment: mean gestational week 15, GW Gestational week, Hb Haemoglobin, ID Iron deficiency, OR Odds ratio, postpartum mean 14 weeks after delivery, postpartum ID by SF serum ferritin < 15 µg/L, postpartum anaemia Haemoglobin < 12.0 g/dL, postpartum ID by sTfR soluble transferrin receptor  > 4.4 mg/L, postpartum ID by TBI total body iron < 0 mg/kg, SF Serum ferritin, sTfR Soluble transferrin receptor, TBI Total body iron
  2. a Linear regression analyses to assess the association between use of supplementation in gestational week 28 and changes in SF, sTfR, TBI and Hb from enrolment to 14 weeks postpartum in iron depleted women (SF < 20 μg/L) recommended supplements at enrolment (top panel) or not (bottom panel) in the STORK-G, a multi-ethnic pregnancy cohort from Oslo, Norway, 2008-2010
  3. b Logistic regression analyses to assess the association between use of supplementation in gestational week 28 on iron deficiency by SF, sTfR, TBI and anaemia in iron depleted women (SF < 20 μg/L) recommended supplements at enrolment (top panel) or not (bottom panel) in the STORK-G, a multi-ethnic pregnancy cohort from Oslo, Norway, 2008-2010
  4. c Both unadjusted and adjusted beta and odds ratios are presented. The fully adjusted model included SF concentration at enrolment, gestational week, age, parity, socioeconomic position, diet, ethnicity, and use of supplement in gestational week 28
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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