Incremental predictive value of platelet parameters for preeclampsia: results from a large prospective cohort study

Table 4 The incremental value of platelet parameters at 16–19 gestational weeks for preeclampsia prediction (n = 9346)

	NRI	p- value	Event NRI	p- value	Non-Event NRI	p- value	IDI	p- value	Relative IDI (%)
Total PE (n = 130)
Base model	Ref		Ref		Ref		Ref		Ref
Base model + PC	0.240	0.007	0.28	0.002	-0.04	< 0.001	0.0001	0.859	0.51
Base model + MPV	0.216	0.014	0.06	0.483	0.15	< 0.001	0.0016	0.016	11.72
Base model + PCT	0.321	< 0.001	0.42	< 0.001	-0.09	< 0.001	0.0012	0.018	8.56
Base model + PDW	0.106	0.231	0.46	< 0.001	-0.36	< 0.001	0.0004	0.107	2.77
Base model + PC + MPV + PCT + PDW	0.178	0.043	0.08	0.381	0.10	< 0.001	0.0020	0.007	14.77
Preterm PE (n = 35)
Base model	Ref		Ref		Ref		Ref		Ref
Base model + PC	0.341	0.044	-0.31	0.063	0.66	< 0.001	0.0003	0.801	2.51
Base model + MPV	0.462	0.006	-0.03	0.866	0.49	< 0.001	0.0054	0.190	42.81
Base model + PCT	0.675	< 0.001	0.77	< 0.001	-0.10	< 0.001	0.0025	< 0.001	19.44
Base model + PDW	0.173	0.306	0.60	< 0.001	-0.43	< 0.001	0.0006	0.025	4.89
Base model + PC + MPV + PCT + PDW	0.793	< 0.001	0.43	0.011	0.36	< 0.001	0.0069	0.035	54.48
Term PE (n = 95)
Base model	Ref		Ref		Ref		Ref		Ref
Base model + PC	0.240	0.020	-0.03	0.758	0.27	< 0.001	0.0002	0.606	1.93
Base model + MPV	0.149	0.148	0.26	0.010	-0.11	< 0.001	0.0009	0.031	9.82
Base model + PCT	0.201	0.051	0.14	0.182	0.06	< 0.001	0.0003	0.252	2.97
Base model + PDW	0.160	0.120	0.89	< 0.001	-0.73	< 0.001	0.0015	< 0.001	16.22
Base model + PC + MPV + PCT + PDW	0.254	0.014	0.16	0.124	0.10	< 0.001	0.0022	0.001	23.16

Multivariate logistic regression models were used to develop the base models with the recognized historic risk factors recommended by NICE and ACOG, including maternal age (continuous), pre-pregnancy weight (continuous), height (continuous), cigarette smoking during pregnancy (yes or no), parity (multiparous or nulliparous), inter-pregnancy interval (continuous), way of conception (spontaneous or in-vitro fertilization), history of chronic hypertension (yes or no), history of pre-existing diabetes mellitus (yes or no), family history of chronic hypertension (yes or no)
PE preeclampsia, PC platelet count, MPV mean platelet volume, PCT plateletcrit, PDW platelet distribution width, NRI net reclassification improvement, IDI integrated discrimination improvement

ISSN: 1471-2393