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Table 3 Detection rates for preeclampsia < 37, ≥ 37 weeks of gestation, and for all preeclampsia for 5% and 10% false-positive rates based on maternal characteristics and platelet parameters at 16–19 gestational weeks (n = 9346)

From: Incremental predictive value of platelet parameters for preeclampsia: results from a large prospective cohort study

 

Preterm PE

Term PE

Total PE

 

AUC

p-value

Detection rate (95%)

AUC

p-value

Detection rate (95%)

AUC

p-value

Detection rate (95%)

 

FPR 5%

FPR 10%

FPR 5%

FPR 10%

FPR 5%

FPR 10%

Base model

0.775

 

22.9 (8.6–37.1)

45.7 (28.6–62.9)

0.674

 

17.9 (10.5–27.4)

34.7 (25.3–44.2)

0.694

 

19.2 (12.3–27.7)

37.7 (29.2–46.2)

Plus

 PC

0.786

0.332

20.0 (8.6–34.3)

40.0 (22.9–57.1)

0.683

0.184

17.9 (10.5–26.3)

36.8 (27.4–46.3)

0.706

0.018

21.5 (13.9–29.2)

35.4 (26.9–43.9)

 MPV

0.807

0.158

34.3 (17.1–51.4)

48.6 (31.4–65.7)

0.677

0.639

21.1 (12.6–31.6)

34.7 (25.3–45.3)

0.700

0.445

21.5 (14.6–29.2)

38.5 (30.6–47.7)

 PCT

0.821

0.066

25.7 (11.4–40.0)

42.9 (25.7–60.0)

0.679

0.366

19.0 (11.6–27.4)

34.7 (26.3–45.3)

0.711

0.041

21.4 (13.9–29.2)

33.9 (26.2–43.1)

 PDW

0.772

0.704

22.9 (11.4–37.1)

42.9 (28.6–60.0)

0.687

0.168

22.1 (12.6–31.6)

34.7 (25.3–44.2)

0.696

0.539

20.8 (13.9–27.7)

36.2 (27.7–43.9)

 PC + MPV + PCT + PDW

0.849

0.015

31.4 (17.1–48.6)

48.6 (31.4–65.7)

0.701

0.021

23.2 (14.7–32.6)

34.7 (25.3–45.3)

0.717

0.015

22.3 (14.6–30.0)

38.5 (29.2–46.9)

  1. Multivariate logistic regression models were used to develop the base models with the recognized historic risk factors recommended by NICE and ACOG, including maternal age (continuous), pre-pregnancy weight (continuous), height (continuous), cigarette smoking during pregnancy (yes or no), parity (multiparous or nulliparous), inter-pregnancy interval (continuous), way of conception (spontaneous or in-vitro fertilization), history of chronic hypertension (yes or no), history of pre-existing diabetes mellitus (yes or no), family history of chronic hypertension (yes or no)
  2. PE preeclampsia, PC platelet count, MPV mean platelet volume, PCT plateletcrit, PDW platelet distribution width, AUC areas under the ROC