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Table 1 Eligibility Criteria Pertaining to the Population and Clinical Areas, Interventions, Comparators, Attributes of Clinical Practice Guidelines and Recommendation Characteristics (Picar) Statement

From: Clinical practice guidelines for the antenatal management of dichorionic diamniotic twin pregnancies: a systematic review

PICAR Framework

Eligibility Criteria

Population, clinical indication(s), and condition(s).

Study population

• Guidelines focused on the management of multiple pregnancies, in high income countries, containing recommendations applicable to the antenatal management of DCDA twin pregnancies

• Humans only

Clinical Investigation

• Antenatal management of DCDA twin pregnancies

Clinical condition

• DCDA twin pregnancy is defined as each fetus having their own separate inner membrane (amnion) and outer membrane (chorion). For the purpose of this review, there is a specific focus on antenatal management of DCDA twin pregnancies.

• The antenatal period extends from the start of pregnancy to the onset of labour

Interventions

• Any intervention focusing on the antenatal management of DCDA twin pregnancies

Comparator(s), Comparisons, and (key) Content

• Any comparator or comparison

• Key clinical practice guideline (CPG) content of interest is DCDA twin pregnancy antenatal management (including general twin pregnancy recommendations)

Attributes of eligible CPGs

Scope

• Cover any aspect of antenatal care for DCDA twin pregnancies.

• Clinical practice guidelines only

• Must be published

Language

• Full text CPGs in any language

Year of publication

• 2000 onwards

Developing/ publishing organisation

• Only CPGs issued or endorsed by national or international scientific societies, professional colleges, charitable organisations, and government organisations will be included.

Country of publication

• High income countries (83 countries), as defined by the world bank. This is due to the large discrepancies in care systems and management of care between high, low, and middle-income countries (25).

Version

• Current version only

Development process

• Evidence and/or consensus-based

Quality of evidence

• No maximum quality score based on the AGREE II and AGREE-REX instruments are required for eligibility. ALL relevant CPGs will be included in the review.

• The quality score will be used to interpret the review findings and will be addressed in the discussion.

Recommendations characteristics and ‘other’ considerations

• Guidelines must have a twin pregnancy or multiple pregnancy focus.

• Eligible recommendations should be applicable to antenatal care of DCDA twin pregnancies. These include general recommendations for the management of a twin pregnancy and DCDA specific recommendations. Recommendations specific to monochorionic twin pregnancies, triplets or higher order multiples are not eligible for inclusion.

• Recommendations will be considered if they are located anywhere within the guideline document (e.g. main text, algorithms, or tables).

• Guidelines addressing any aspect of antenatal management of DCDA twin pregnancies without recommendations are eligible for inclusion.