Table 3 Consensus classification of the stillbirth cases with the agreement between the three evaluators before reaching consensus and the agreement between reviewers with the consensus
Case | Agreement between evaluators | Consensus | Agreement between reviewers | Explanation |
|---|---|---|---|---|
# 1 | 1/3 | Certain | 2/3 | Some considered cases with very suggestive placental findings as “certain”, others preferred probable as there was no identification of SARS-CoV-2 on the placenta |
# 2 | 3/3 | Certain | 1/3 | Two reviewers preferred: “probable” because of IUGR and no identification of SARS-CoV-2 on the placenta |
Twins 1 | 3/3 | Certain | 3/3 | |
Twins 2 | 3/3 | Certain | 2/3 | One reviewer classified “possible” as no placental examination had been performed and because of low birth weight in both infants |
# 3 | 1/3 | Probable | 1/3 | Woman with type 1 diabetes and keto-acidosis. Some considered that keto-acidosis might have been caused by COVID; others preferred “possible” due to presence of other risk factors for IUFD |
# 4 | 1/3 | Probable | 2/3 | Half preferred “possible” |
# 5 | 2/3 | Probable | 1/3 | Half preferred “possible”; preeclampsia could have caused the IUFD |
# 6 | 1/3 | Possible | 3/3 | PPROM and chorio-amnionitis can be caused by other pathogens (no identification was performed) |
# 7 | 3/3 | Possible | 3/3 | |
# 8 | 2/3 | Possible | 2/3 | Incoherent timing; several other RF |
# 9 | 2/3 | Possible | 3/3 | PPROM and chorio-amnionitis can be caused by other pathogens (no identification was performed) |
# 10 | 3/3 | Possible | 2/3 | One considered “unlikely” as placental examination was normal |
# 11 | 2/3 | Possible | 2/3 | RF: past history of several mid-trimester losses, cervical incompetence? |
# 12 | 1/3 | Possible | 2/3 | Two considered it “unlikely”, because of severe preeclampsia. One considered “probable” as preeclampsia could have been associated with COVID |
# 13 | 3/3 | Unlikely | 2/3 | A reviewer preferred “possible” as no pathological examination of placenta was performed and there was no other explanation for IUFD |
# 14 | 3/3 | Unlikely | 3/3 | |
# 15 | 3/3 | Unlikely | 3/3 | |
# 16 | 2/3 | Unlikely | 2/3 | Incomplete investigation, so according to 2/6 a COVID infection could not be excluded (“possible”) |