Table 1 Stratification analysis between the risk factors and death of AFLP patients

Maternal age at first AFLP pregnancy, y, (mean ± SD)

27.21 ± 4.95

26.71 ± 4.59

29.6 ± 6.43

0.30

BMI, Kg/m², (mean ± SD)

24.07 ± 3.27

24.63 ± 2.90

21.4 ± 3.98

0.58

Gravidity, (mean ± SD)

1.69 ± 0.81

1.67 ± 0.82

1.80 ± 0.84

0.91

Multiparae

57(19.7%)

48(20.0%)

9(18.0%)

0.85

Fetal sex male

233(80.3%)

192(80.0%)

41(82.0%)

0.85

Gestational age, d, (mean ± SD)

253.10 ± 17.58

253.29 ± 17.55

252.20 ± 19.75

0.60

Multiplets

25(8.6%)

23(9.6%)

2(4.0%)

0.27

Days from symptom onset to hospitalization, d, (mean ± SD)

12.89 ± 16.51

8.26 ± 5.14

35.00 ± 32.40

 < 0.01

Days from symptom onset to parturition, d (mean ± SD)

14.25 ± 17.20

9.05 ± 4.96

38.20 ± 31.85

 < 0.01

APACHE II score, (mean ± SD)

19.61 ± 9.20

12.77 ± 4.96

30.20 ± 3.49

0.03

Swansea score, (mean ± SD)

7.52 ± 1.48

7.38 ± 1.56

8.20 ± 0.84

0.22

Complications

 Hypertension before pregnancy

7(2.4%)

5(2.1%)

2(4.0%)

0.42

 Preeclampsia

54(18.6%)

42(17.5%)

12(24.0%)

0.32

 Hypothyroidism during pregnancy

6(2.1%)

4(1.7%)

2(4.0%)

0.28

 Gestational diabetes

17(6.6%)

14(5.8%)

3(6.0%)

0.99

 Encephalopathy

81(27.9%)

43(17.9%)

38(76.0%)

0.01

 Infection

60(20.7%)

48(20.0%)

12(24.0%)

0.57

 Postpartum Hemorrhage

39(13.4%)

26(10.8%)

13(26.0%)

0.01

 HELLP syndrome

34(11.7%)

25(10.4%)

9(18.0%)

0.15

 Placenta previa

33(11.4%)

28(11.7%)

5(10.0%)

0.99

 Placental Abruption

39(13.4%)

33(13.8%)

6(12.0%)

0.99

 Fetal distress

130(44.8%)

101(42.1%)

29(58.0%)

0.04

 Fetal death

78(26.9%)

53(22.1%)

25(50.0%)

 < 0.01

 Others

19(6.6%)

12(5.0%)

7(14.0%)

0.03

Lab on first visit (mean ± SD)

 Hemoglobin(g/L)

112.00 ± 25.24

115.58 ± 25.60

94.80 ± 15.64

0.29

 Platelet (*10⁹/L)

141.66 ± 80.49

133.33 ± 78.48

181.60 ± 86.78

0.95

 TBil (mmol/L)

154.70 ± 99.52

146.54 ± 89.28

193.86 ± 145.56

0.02

 DBil (mmol/L)

132.13 ± 94.21

122.83 ± 81.29

176.74 ± 145.35

0.17

 ALT (IU/L)

314.59 ± 658.66

116.20 ± 35.10

355.92 ± 719.44

0.03

 PT (s)

22.49 ± 19.67

21.73 ± 21.38

26.14 ± 7.79

0.75

 APTT(s)

49.23 ± 16.76

45.70 ± 14.41

66.18 ± 18.40

0.33

 Prothrombin activity (%)

48.74 ± 18.20

52.83 ± 16.54

29.12 ± 12.28

0.06

 Scr (umol/L)

190.76 ± 76.41

187.67 ± 73.01

205.6 ± 99.40

0.27

 BUN (mmol/L)

7.47 ± 3.88

7.80 ± 4.05

5.90 ± 2.61

0.41

 WBC(*10⁶/L)

15.81 ± 6.16

16.40 ± 6.18

12.96 ± 5.82

0.54

 Trioxypurine (μmol/L)

360.62 ± 148.87

351.13 ± 149.08

406.20 ± 155.59

0.59

Management

 Plasma exchange

79(27.2%)

68(28.3%)

11(22.0%)

0.39

 Bilirubin adsorption

22(7.6%)

10(4.2%)

12(24.0%)

 < 0.01

 CRRT

107(36.9%)

82(34.2%)

25(50.0%)

0.04

 Cesarean section

267(92.1%)

223(92.9%)

43(86.0%)

0.15

 Hysterectomy

34(11.7%)

32(13.3%)

2(4.0%)

0.09