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Fig. 2 | BMC Pregnancy and Childbirth

Fig. 2

From: Loss of p16 does not protect against premature ovarian insufficiency caused by alkylating agents

Fig. 2

Effect of p16 deletion on the hormone levels of mice treated with BUL + CTX. Three months after administering AAs, the sera of mice were collected to detect the levels of (A) AMH, (B) FSH, (C) LH and (D) E2. Compared with WT mice: ***P < 0.001. Compared with p16 KO mice: ##P < 0.01; ###P < 0.001. n = 12 mice for each group. WT: WT mice; WT + M: WT mice treated with BUL + CTX; KO mice: untreated p16 KO mice; KO + M: p16 KO mice treated with BUL + CTX.

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